MIRC-X/CHARA: sensitivity improvements with an ultra-low noise SAPHIRA detector

This is the final version of the article. Available from Society of Photo Optical Instrumentation Engineers (SPIE) via the DOI in this record.MIRC-X is an upgrade of the six-telescope infrared beam combiner at the CHARA telescope array, the world's largest baseline interferometer in the optical/infrared, located at the Mount Wilson Observatory in Los Angeles. The upgraded instrument features an ultra-low noise and fast frame rate infrared camera (SAPHIRA detector) based on e-APD technology. We report the MIRC-X sensitivity upgrade work and first light results in detail focusing on the detector characteristics and software architecture.MIRC-X is funded, in parts, by a Starting Grant from the European Research Council (ERC; grant agreement No. 639889, PI: Kraus) and builds on earlier investments from the University of Michigan and the National Science Foundation (NSF, PI: Monnier). This research has made use of the Jean-Marie Mariotti Center OIFits Explorer service (http://www.jmmc.fr/oifitsexplorer)

Generalizability of the Added Benefits of Guided Tissue Regeneration in the Treatment of Deep Intrabony Defects. Evaluation in a Multi-Center Randomized Controlled Clinical Trial

Background: Several studies have shown that GTR therapy of intrabony defects results in significantly better outcomes than access flap alone. Most of the available data, however, have been produced in highly controlled research environments by a small group of investigators. Generalizability of results to different clinicians and different subject populations has not been evaluated so far. Methods: This parallel group study involved 143 patients recruited in a practicebased research network of 11 offices in 7 countries. It was designed to evaluate: 1) the applicability of the documented added benefits of GTR in the treatment of intrabony defects to different populations, and 2) the generalizability of the expected results to different clinicians. GTR was compared to access flap alone. Defects, one in each patient, were accessed with a previously described papilla preservation flap in both the test and control group. In addition, GTR sites received application of a bioabsorbable poly-D,L-lactide-co-glycolide membrane. A stringent plaque control regimen was enforced in all patients during the 1-year observation period. Outcomes included gains in clinical attachment (CAL) and reductions in probing depth. Results: Observed gains in CAL were 2.18 ± 1.46 mm for access flap and 3.04 ± 1.64 mm for the GTR-treated group. The treatment-associated difference was statistically significant (P = 0.03) after correcting for both center effect and defect anatomy. Among the various centers, a 1.73 mm difference in CAL gain was observed. This is a clinically relevant amount, which underlines the significance of center variability in the outcome of periodontal surgical procedures. A frequency distribution analysis of the obtained CAL gains indicated that GTR treatment of deep intrabony defects decreased, with respect to the access flap control, the probability of obtaining only a modest attachment gain at 1 year. Conversely, CAL gains of 4 mm or more were.link_to_subscribed_fulltex

Generalizability of the Added Benefits of Guided Tissue Regeneration in the Treatment of Deep Intrabony Defects. Evaluation in a Multi-Center Randomized Controlled Clinical Trial

Background: Several studies have shown that GTR therapy of intrabony defects results in significantly better outcomes than access flap alone. Most of the available data, however, have been produced in highly controlled research environments by a small group of investigators. Generalizability of results to different clinicians and different subject populations has not been evaluated so far. Methods: This parallel group study involved 143 patients recruited in a practicebased research network of 11 offices in 7 countries. It was designed to evaluate: 1) the applicability of the documented added benefits of GTR in the treatment of intrabony defects to different populations, and 2) the generalizability of the expected results to different clinicians. GTR was compared to access flap alone. Defects, one in each patient, were accessed with a previously described papilla preservation flap in both the test and control group. In addition, GTR sites received application of a bioabsorbable poly-D,L-lactide-co-glycolide membrane. A stringent plaque control regimen was enforced in all patients during the 1-year observation period. Outcomes included gains in clinical attachment (CAL) and reductions in probing depth. Results: Observed gains in CAL were 2.18 ± 1.46 mm for access flap and 3.04 ± 1.64 mm for the GTR-treated group. The treatment-associated difference was statistically significant (P = 0.03) after correcting for both center effect and defect anatomy. Among the various centers, a 1.73 mm difference in CAL gain was observed. This is a clinically relevant amount, which underlines the significance of center variability in the outcome of periodontal surgical procedures. A frequency distribution analysis of the obtained CAL gains indicated that GTR treatment of deep intrabony defects decreased, with respect to the access flap control, the probability of obtaining only a modest attachment gain at 1 year. Conversely, CAL gains of 4 mm or more were