Banks as the Actors of a Modern Monetary Policy in Russia: Effects of Exposure on the Econom

The article's relevance is determined by the fact that in the conditions of a bank-oriented financial system the "signals" from the central bank regarding decisions about the monetary policy go to the economy via banks, through which the main channels of the transmission mechanism of the monetary policy are implemented. The analysis of the effects of banks as the actors of the monetary policy is therefore relevant. The article, based on a study of the elements of investment potential for their impact on GDP, contains conclusions about the possibility of achieving economic growth as one of the strategic goals the monetary policy through the main channels of the transmission mechanism using its standard tools. The article is to identify and quantify the factors that have significant effects on economic growth through the impact on investment potential. The change in the Bank of Russia's key interest affects only some of the investment potential elements such as deposits of legal entities in rubles. Such impact can slightly improve GDP. The use of monetary policy tools will enable the influence on the change of the nominal interest rate and, therefore, the adjustment of real rates, and it may also affect aggregate demand (consumption and investment potential)

Categories affect color perception of only some simultaneously present objects

There is broad empirical evidence suggesting that higher-level cognitive processes, such as language, categorization, and emotion, shape human visual perception. For example, categories that we acquire throughout lifetime have been found to alter our perceptual discriminations and distort perceptual processing. Here, we study categorical effects on perception by adapting the perceptual matching task to minimize the potential non-perceptual influences on the results. We found that the learned category-color associations bias human color matching judgments away from their category ideal on a color continuum. This effect, however, unequally biased two objects (probe and manipulator) that were simultaneously present on the screen, thus demonstrating a more nuanced picture of top-down influences on perception than has been assumed both by the theories of categorical perception and the El Greco methodological fallacy. We suggest that only the concurrent memory for visually present objects is subject to a contrast-from-caricature distortion due to category-association learning

Excess Capacity Learning

Many paradigms in cognitive science posit that human learning is characterized by a limited capacity to represent the information relevant for a given task. We argue that excess capacity -- using more representational resources than needed for a task at hand -- is a plausible alternative paradigm for the study of human learning. Leveraging recent results from machine learning, we show that excess capacity can be consistent with high predictive ability. We also review extant empirical findings from the cognitive science literature, demonstrating that excess capacity learning can account for a range of empirical phenomena, such as humans' simultaneous yet apparently contradictory tendency to both memorize observations and capture higher-level patterns in them. We conclude by discussing promising directions for future inquiry under the excess capacity learning paradigm

Wnt/β-catenin signaling regulates vertebrate limb regeneration

The cellular and molecular bases allowing tissue regeneration are not well understood. By performing gain- and loss-of-function experiments of specific members of the Wnt pathway during appendage regeneration, we demonstrate that this pathway is not only necessary for regeneration to occur, but it is also able to promote regeneration in axolotl, Xenopus, and zebrafish. Furthermore, we show that changes in the spatiotemporal distribution of β-catenin in the developing chick embryo elicit apical ectodermal ridge and limb regeneration in an organism previously thought not to regenerate. Our studies may provide valuable insights toward a better understanding of adult tissue regeneration

An Evaluation of Experimental Sampling Strategies for Autonomous Empirical Research in Cognitive Science

In light of constraints inherent to empirical research, such as finite time and resources, there has been growing interest in using artificial intelligence to streamline the scientific process. However, despite advancements in automating scientific discovery, the implementation of strategies for sampling useful experiments remains a challenge. This metascientific study evaluates different experimental sampling strategies based on their effectiveness in advancing the discovery of linear models of human cognition based on synthetic data. We investigate the hypothesis put forth by Dubova et al. (2022) that random sampling of experiments is more effective than model-driven sampling. Indeed, the results of this study indicate that random sampling is more effective in a majority of cases, and that the underperformance of model-driven strategies can be attributed to a narrow sampling of the design space. Despite limitations in our approach, the work presented offers a novel framework for the metascientific study of autonomous empirical research

Thermosensitive Intravitreal In Situ Implant of Cefuroxime Based on Poloxamer 407 and Hyaluronic Acid

The main method of treatment and prevention of endophthalmitis is a combination of intravitreal and topical administration of antibiotics, such as cefuroxime moxifloxacin or vancomycin. However, this method is ineffective due to the rapid elimination of the drug. This problem can be solved with the help of intravitreal in situ injection systems, which are injected with a syringe into the vitreous body and provide prolonged action of the drug at the focus of inflammation. Under the influence of temperature, the liquid drug undergoes a phase transition and turns into a gel after injection. This ensures its prolonged action. The study aimed to develop an intravitreal in situ cefuroxime delivery system for the treatment of endophthalmitis based on a thermosensitive biodegradable composition of poloxamer 407 and hyaluronic acid. A combination of poloxamer Kolliphor® P407, Kolliphor® P188, and PrincipHYAL® hyaluronic acids of different molecular weights was used as a delivery system. The potency of cefuroxime solid dispersion with polyvinylpyrrolidone-10000, polyethylene glycol-400, and polyethylene glycol-1500 in a 1:2 ratio was studied for prolonged action compared to cefuroxime substance. The experimental formulations were studied for the parameters of gelation temperature in a long-term test (4 months), pH, and release of cefuroxime using dialysis bags. To study the distribution parameter in the vitreous body, an in vitro model (1/13) was developed, which was a hollow agar sphere filled with 1% (w/v) polyacrylate gel. For the superior formulations, a HET-CAM test (chorioallantoic membrane test) was performed to determine the absence of irritant effects. According to the study results, a formulation containing a solid dispersion of cefuroxime:PEG-400 (1:2), the matrix of which contained 18% (w/v) Kolliphor® P407 poloxamer, 3% (w/v) Kolliphor® P188 poloxamer, and 0.5% (w/v) hyaluronic acid (1400–1800), was selected. This sample had an average gelation temperature of 34.6 °C, pH 6.7 ± 0.5, and a pronounced prolonged effect. Only 7.6% was released in 3 h of the experiment, whereas about 38% of cefuroxime was released in 72 h. No irritant effect on the chorioallantoic membrane was observed for any formulations studied