Comparative effectiveness of intensity modulated radiation therapy to 3-dimensional conformal radiation in locally advanced lung cancer: pathological and clinical outcomes.

OBJECTIVE: Intensity-modulated radiotherapy (IMRT) has better normal-tissue sparing compared with 3-dimensional conformal radiation (3DCRT). We sought to assess the impact of radiation technique on pathological and clinical outcomes in locally advanced non-small cell lung cancer (LANSCLC) treated with a trimodality strategy. METHODS: Retrospective review of LANSCLC patients treated from August 2012 to August 2018 at Sheba Medical Center, Israel. The trimodality strategy consisted of concomitant chemoradiation to 60 Gray (Gy) followed by completion surgery. The planning target volume (PTV) was defined by co-registered PET/CT. Here we compare the pathological regression, surgical margin status, local control rates (LC), disease free (DFS) and overall survival (OS) between 3DCRT and IMRT. RESULTS: Our cohort consisted of 74 patients with mean age 62.9 years, male in 51/74 (69%), adenocarcinoma in 46/74 (62.1%), stage 3 in 59/74 (79.7%) and chemotherapy in 72/74 (97.3%). Radiation mean dose: 59.2 Gy (SD ± 3.8). Radiation technique : 3DCRT in 51/74 (68.9%), IMRT in 23/74 (31%). Other variables were similar between groups.Major pathological response (including pathological complete response or less than 10% residual tumor cells) was similar: 32/51 (62.7%) in 3DCRT and 15/23 (65.2%) in IMRT, p=0.83. Pathological complete response (pCR) rates were similar: 17/51 (33.3%) in 3DCRT and 8/23 (34.8%) in IMRT, p=0.9. Surgical margins were negative in 46/51 (90.1%) in 3DCRT vs. 17/19 (89.4%) in IMRT (p=1.0).The 2-year LC rates were 81.6% (95% CI 69-89.4%); DFS 58.3% (95% CI 45.5-69%) and 3-year OS 70% (95% CI57-80%). Comparing radiation techniques, there were no significant differences in LC (p=0.94), DFS (p=0.33) and OS (p=0.72). CONCLUSION: When used to treat LANSCLC in the neoadjuvant setting, both IMRT and 3DCRT produce comparable pathological and clinical outcomes. ADVANCES IN KNOWLEDGE: This study validates the real-world effectiveness of IMRT compared to 3DCRT

Measurement of inclusive J/ψ\psi pair production cross section in pp collisions at s=13\sqrt{s} = 13 TeV

International audienceThe production cross section of inclusive J/$\psi$ pairs in pp collisions at a centre-of-mass energy $\sqrt{s} = 13$ TeV is measured with ALICE. The measurement is performed for J/$\psi$ in the rapidity interval $2.5 0$. The production cross section of inclusive J/$\psi$ pairs is reported to be $10.3 \pm 2.3 {\rm (stat.)} \pm 1.3 {\rm (syst.)}$ nb in this kinematic interval. The contribution from non-prompt J/$\psi$ (i.e. originated from beauty-hadron decays) to the inclusive sample is evaluated. The results are discussed and compared with data

Inclusive and multiplicity dependent production of electrons from heavy-flavour hadron decays in pp and p−-Pb collisions

International audienceMeasurements of the production of electrons from heavy-flavour hadron decays in pp collisions at $\sqrt{s} = 13$ TeV at midrapidity with the ALICE detector are presented down to a transverse momentum ($p_{\rm T}$) of 0.2 GeV$/c$ and up to $p_{\rm T} = 35$ GeV$/c$, which is the largest momentum range probed for inclusive electron measurements in ALICE. In p$-$Pb collisions, the production cross section and the nuclear modification factor of electrons from heavy-flavour hadron decays are measured in the $p_{\rm T}$ range $0.5 < p_{\rm T} < 26$ GeV$/c$ at $\sqrt{s_{\rm NN}} = 8.16$ TeV. The nuclear modification factor is found to be consistent with unity within the statistical and systematic uncertainties. In both collision systems, first measurements of the yields of electrons from heavy-flavour hadron decays in different multiplicity intervals normalised to the multiplicity-integrated yield (self-normalised yield) at midrapidity are reported as a function of the self-normalised charged-particle multiplicity estimated at midrapidity. The self-normalised yields in pp and p$-$Pb collisions grow faster than linear with the self-normalised multiplicity. A strong $p_{\rm T}$ dependence is observed in pp collisions, where the yield of high-$p_{\rm T}$ electrons increases faster as a function of multiplicity than the one of low-$p_{\rm T}$ electrons. The measurement in p$-$Pb collisions shows no $p_{\rm T}$ dependence within uncertainties. The self-normalised yields in pp and p$-$Pb collisions are compared with measurements of other heavy-flavour, light-flavour, and strange particles, and with Monte Carlo simulations

Measurement of the angle between jet axes in Pb−-Pb collisions at sNN=5.02\sqrt{s_{\rm NN}} = 5.02 TeV

International audienceThis letter presents the first measurement of the angle between different jet axes (denoted as ${\Delta}R$) in Pb$-$Pb collisions. The measurement is carried out in the 0$-$10% most-central events at $\sqrt{s_{\rm NN}} = 5.02$ TeV. Jets are assembled by clustering charged particles at midrapidity using the anti-$k_{\rm T}$ algorithm with resolution parameters $R=0.2$ and $0.4$ and transverse momenta in the intervals $40 < p_{\rm T}^{\rm ch jet} < 140$ GeV/$c$ and $80 < p_{\rm T}^{\rm ch jet} < 140$ GeV/$c$, respectively. Measurements at these low transverse momenta enhance the sensitivity to quark$-$gluon plasma (QGP) effects. A comparison to models implementing various mechanisms of jet energy loss in the QGP shows that the observed narrowing of the Pb$-$Pb distribution relative to pp can be explained if quark-initiated jets are more likely to emerge from the medium than gluon-initiated jets. These new measurements discard intra-jet $p_{\rm T}$ broadening as described in a model calculation with the BDMPS formalism as the main mechanism of energy loss in the QGP. The data are sensitive to the angular scale at which the QGP can resolve two independent splittings, favoring mechanisms that incorporate incoherent energy loss

W±^\pm-boson production in p−-Pb collisions at sNN=8.16\sqrt{s_{NN}} = 8.16 TeV and PbPb collisions at sNN=5.02\sqrt{s_{NN}} = 5.02 TeV

The production of the W$^{±}$ bosons measured in p–Pb collisions at a centre-of-mass energy per nucleon–nucleon collision $\sqrt{s_{\textrm{NN}}}$ = 8.16 TeV and Pb–Pb collisions at $\sqrt{s_{\textrm{NN}}}$ = 5.02 TeV with ALICE at the LHC is presented. The W$^{±}$ bosons are measured via their muonic decay channel, with the muon reconstructed in the pseudorapidity region −4 10 GeV/c. While in Pb–Pb collisions the measurements are performed in the forward (2.5 10$GeV/$c$. While in Pb$-$Pb collisions the measurements are performed in the forward ($2.5 < y^\mu_{\rm cms} < 4$) rapidity region, in p$-$Pb collisions, where the centre-of-mass frame is boosted with respect to the laboratory frame, the measurements are performed in the backward ($-4.46 < y^\mu_{\rm cms} < -2.96$) and forward ($2.03 < y^\mu_{\rm cms} < 3.53$) rapidity regions. The W$^{-}$and W$^{+}$production cross sections, lepton-charge asymmetry, and nuclear modification factors are evaluated as a function of the muon rapidity. In order to study the production as a function of the p$-$Pb collision centrality, the production cross sections of the W$^{-}$and W$^{+}$bosons are combined and normalised to the average number of binary nucleon$-$nucleon collision$\langle N_\mathrm{coll} \rangle$. In Pb$-$Pb collisions, the same measurements are presented as a function of the collision centrality. Study of the binary scaling of the W$^\pm$-boson cross sections in p$-$Pb and Pb$-$Pb collisions is also reported. The results are compared with perturbative QCD (pQCD) calculations, with and without nuclear modifications of the Parton Distribution Functions (PDFs), as well as with available data at the LHC. Significant deviations from the theory expectations are found in the two collision systems, indicating that the measurements can provide additional constraints for the determination of nuclear PDF (nPDFs) and in particular of the light-quark distributions

Measurement of inclusive and leading subjet fragmentation in pp and Pb–Pb collisions at sNN \sqrt{s_{\textrm{NN}}} = 5.02 TeV

This article presents new measurements of the fragmentation properties of jets in both proton--proton (pp) and heavy-ion collisions with the ALICE experiment at the Large Hadron Collider (LHC). We report distributions of the fraction $z_r$ of transverse momentum carried by subjets of radius $r$ within jets of radius $R$. Charged-particle jets are reconstructed at midrapidity using the anti-$k_{\rm{T}}$ algorithm with jet radius $R=0.4$, and subjets are reconstructed by reclustering the jet constituents using the anti-$k_{\rm{T}}$ algorithm with radii $r=0.1$ and $r=0.2$. In proton--proton collisions, we measure both the inclusive and leading subjet distributions. We compare these measurements to perturbative calculations at next-to-leading logarithmic accuracy, which suggest a large impact of threshold resummation and hadronization effects on the $z_r$ distribution. In heavy-ion collisions, we measure the leading subjet distributions, which allow access to a region of harder jet fragmentation than has been probed by previous measurements of jet quenching via hadron fragmentation distributions. The $z_r$ distributions enable extraction of the parton-to-subjet fragmentation function and allow for tests of the universality of jet fragmentation functions in the quark-gluon plasma (QGP). We find indications that there is a turnover in the ratio between the distributions in \mbox{Pb--Pb} and $\mathrm{p\kern-0.05em p}$ collisions as $z_r \rightarrow 1$, exposing qualitatively new possibilities to disentangle competing jet quenching mechanisms. By comparing our results to theoretical calculations based on an independent extraction of the parton-to-jet fragmentation function, we find consistency with the universality of jet fragmentation and no indication of factorization breaking in the QGP.This article presents new measurements of the fragmentation properties of jets in both proton–proton (pp) and heavy-ion collisions with the ALICE experiment at the Large Hadron Collider (LHC). We report distributions of the fraction z$_{r}$ of transverse momentum carried by subjets of radius r within jets of radius R. Charged-particle jets are reconstructed at midrapidity using the anti-k$_{T}$ algorithm with jet radius R = 0.4, and subjets are reconstructed by reclustering the jet constituents using the anti-k$_{T}$ algorithm with radii r = 0.1 and r = 0.2. In proton–proton collisions, we measure both the inclusive and leading subjet distributions. We compare these measurements to perturbative calculations at next-to-leading logarithmic accuracy, which suggest a large impact of threshold resummation and hadronization effects on the z$_{r}$ distribution. In heavy-ion collisions, we measure the leading subjet distributions, which allow access to a region of harder jet frag- mentation than has been probed by previous measurements of jet quenching via hadron fragmentation distributions. The z$_{r}$ distributions enable extraction of the parton-to-subjet fragmentation function and allow for tests of the universality of jet fragmentation functions in the quark–gluon plasma (QGP). We find no significant modification of z$_{r}$ distributions in Pb–Pb compared to pp collisions. However, the distributions are also consistent with a hardening trend for z$_{r}$< 0.95, as predicted by several jet quenching models. As z$_{r}$ → 1 our results indicate that any such hardening effects cease, exposing qualitatively new possibilities to disentangle competing jet quenching mechanisms. By comparing our results to theoretical calculations based on an independent extraction of the parton-to-jet fragmentation function, we find consistency with the universality of jet fragmentation and no indication of factorization breaking in the QGP.[graphic not available: see fulltext]This article presents new measurements of the fragmentation properties of jets in both proton-proton (pp) and heavy-ion collisions with the ALICE experiment at the LHC. We report distributions of the fraction $z_r$ of transverse momentum carried by subjets of radius $r$ within jets of radius $R$. Charged-particle jets are reconstructed at midrapidity using the anti-$k_{\rm{T}}$ algorithm with jet radius $R=0.4$, and subjets are reconstructed by reclustering the jet constituents using the anti-$k_{\rm{T}}$ algorithm with radii $r=0.1$ and $r=0.2$. In pp collisions, we measure both the inclusive and leading subjet distributions. We compare these measurements to perturbative calculations at next-to-leading logarithmic accuracy, which suggest a large impact of threshold resummation and hadronization effects on the $z_r$ distribution. In heavy-ion collisions, we measure the leading subjet distributions, which allow access to a region of harder jet fragmentation than has been probed by previous measurements of jet quenching via hadron fragmentation distributions. The $z_r$ distributions enable extraction of the parton-to-subjet fragmentation function and allow for tests of the universality of jet fragmentation functions in the quark-gluon plasma (QGP). We find no significant modification of $z_r$ distributions in Pb-Pb compared to pp collisions. However, the distributions are also consistent with a hardening trend for $z_r<0.95$, as predicted by several jet quenching models. As $z_r \rightarrow 1$ our results indicate that any such hardening effects cease, exposing qualitatively new possibilities to disentangle competing jet quenching mechanisms. By comparing our results to theoretical calculations based on an independent extraction of the parton-to-jet fragmentation function, we find consistency with the universality of jet fragmentation and no indication of factorization breaking in the QGP