A screening method for ranking chemicals by their fate and behaviour in the environment and potential toxic effects in humans following non-occupational exposure

A large number of chemicals are released intentionally or unintentionally into the environment each year. These include thousands of substances that are currently listed worldwide and several hundred new substances added annually (Mücke et al., 1986). When these compounds are used, they can reach microorganisms, plants, animals and man either in their original state or in the form of reaction and degradation products via air, water, soil or foodstuffs. Hence environmental chemicals can occur in practically all environmental compartments and ecosystems. It is not feasible to conduct assessments of human exposure and possible associated health effects for all chemicals. Even if the necessary resources were available, reliable data for a quantitative evaluation are likely to be absent in most cases. This has led to the development of schemes for prioritising compounds likely to be of environmental significance. Such schemes can be used to direct future research efforts towards the prioritised compounds. This study was commissioned by the Department of Health (DH) as part of a broader research activity that aims to identify key priority chemicals of concern to human health at routine levels of environmental exposure. The main pathways of human exposure are shown in Figure 1.1. A review of the principal prioritisation schemes used by different organisations to assess the significance of chemical release into the environment has been conducted by the MRC Institute for Environment and Health (IEH, 2003). This review showed that the approaches used by different organisations vary widely, depending on the initial reasons for which the schemes were developed. The basic information presented in the review was used to develop a simple screening method for ranking chemicals. The model used in this prioritisation scheme is outlined in Figure 1.2. The main purpose in developing the prioritisation scheme for DH was to develop a dedicated priority setting method capable of identifying chemicals in air, water, soil and foodstuffs that might pose a significant risk to human health following low level environmental exposure. The methodology was developed in order to identify compounds that required further assessment and those that had data gaps. More detailed risk assessments were conducted at a later stage on those compounds prioritised as being of high importancea. The screening methodology was developed for ‘existing chemicals’ as these are of greatest concern because data on their toxicity and/or fate and behaviour are often unknownb. The production of a priority list was designed to highlight compounds that required further regulatory measures to reduce exposure of the general population and for which an in-depth risk characterisation would be necessary to assist in the evaluation and implementation of activities for reducing environmental risks. This might include an assessment of the costs of such risks to human health and the costs of reduction measures. As the scheme also aimed to identify data gaps that might warrant further investigation, the application of default categories for chemicals with no data was also considered. The overall aim was to develop a screening methodology that is quick, clear and simple to use and that can easily be revised to take into account new information on compounds as and when it becomes available. a Benzene (IEH Report on Benzene in the Environment, R12); 4,6-dichlorocresol, hexachloro-1,3-butadiene, tetrachlorobenzene, 2,4,6-trichlorophenol (reports to DH; available from MRC Institute for Environment and Health b ‘Existing Substances’ are those that were placed in the European Union (EU) market before 1981. Prior to 1981 regulatory requirements were related to products intended for certain uses (e.g. veterinary medicines) and did not require assessment of the hazardous properties of any substance before they were released into the market. For substances placed on the market after 1981 (classified as ‘New Substances’) there is a legal requirement to conduct such assessments. Regulatory agencies require the collection of extensive documentation for safety before a chemical, for example, can be used in foods or commercial products. IEH Web Report W14, posted March 2004 at http://www.le.ac.uk/ieh/ 4 This report describes how physicochemical properties and toxicological data were incorporated into a screening model to assess the potential fate and transfer of chemicals between different environmental compartments and to predict the potential human exposure to toxic chemicals through the inhalation of contaminated air and the ingestion of water and food. It must be stressed, however, that the method devised is a simple screening process and that a more detailed assessment is necessary to determine the potential transfer through the foodchain of a chemical and the full extent of any adverse health effects. Sections 2 and 4 present the physicochemical properties, toxicological data and algorithms used to screen the compounds. Section 3 summarises the groups of chemicals that were included in the screening process. The results of the prioritisation scheme and comments on their limitations and constraints are presented in Section 5

Probing the strange Higgs coupling at lepton colliders using light-jet flavor tagging

We propose a method to probe the coupling of the Higgs to strange quarks by tagging strange jets at future lepton colliders. For this purpose we describe a jet-flavor observable, $J_F$, that is correlated with the flavor of the quark associated with the hard part of the jet. Using this variable, we set up a strangeness tagger aimed at studying the decay $h\to s\bar{s}$. We determine the sensitivity of our method to the strange Yukawa coupling, and find it to be of the order of the standard-model expectation.Comment: 6 pages, v2 accepted for publication in PR

A generalization of the S-function method applied to a Duffing-Van der Pol forced oscillator

In [1,2] we have developed a method (we call it the S-function method) that is successful in treating certain classes of rational second order ordinary differential equations (rational 2ODEs) that are particularly `resistant' to canonical Lie methods and to Darbouxian approaches. In this present paper, we generalize the S-function method making it capable of dealing with a class of elementary 2ODEs presenting elementary functions. Then, we apply this method to a Duffing-Van der Pol forced oscillator, obtaining an entire class of first integrals

Gluon and Ghost Dynamics from Lattice QCD

The two point gluon and ghost correlation functions and the three gluon vertex are investigated, in the Landau gauge, using lattice simulations. For the two point functions, we discuss the approach to the continuum limit looking at the dependence on the lattice spacing and volume. The analytical structure of the propagators is also investigated by computing the corresponding spectral functions using an implementation of the Tikhonov regularisation to solve the integral equation. For the three point function we report results when the momentum of one of the gluon lines is set to zero and discuss its implications.Comment: Proceedings of Light Cone 2016, held in Lisbon, September 2016. Minor changes in text. To appear in Few B Sy

Tightening the belt: Constraining the mass and evolution in SDC335

Recent ALMA observations identified one of the most massive star-forming cores yet observed in the Milky Way; SDC335-MM1, within the infrared dark cloud SDC335.579-0.292. Along with an accompanying core MM2, SDC335 appears to be in the early stages of its star formation process. In this paper we aim to constrain the properties of the stars forming within these two massive millimetre sources. Observations of SDC335 at 6, 8, 23 and 25GHz were made with the ATCA. We report the results of these continuum measurements, which combined with archival data, allow us to build and analyse the spectral energy distributions (SEDs) of the compact sources in SDC335. Three HCHII regions within SDC335 are identified, two within the MM1 core. For each HCHII region, a free-free emission curve is fit to the data allowing the derivation of the sources' emission measure, ionising photon flux and electron density. Using these physical properties we assign each HCHII region a ZAMS spectral type, finding two protostars with characteristics of spectral type B1.5 and one with a lower limit of B1-B1.5. Ancillary data from infrared to mm wavelength are used to construct free-free component subtracted SEDs for the mm-cores, allowing calculation of the bolometric luminosities and revision of the previous gas mass estimates. The measured luminosities for the two mm-cores are lower than expected from accreting sources displaying characteristics of the ZAMS spectral type assigned to them. The protostars are still actively accreting, suggesting that a mechanism is limiting the accretion luminosity, we present the case for two different mechanisms capable of causing this. Finally, using the ZAMS mass values as lower limit constraints, a final stellar population for SDC335 was synthesised finding SDC335 is likely to be in the process of forming a stellar cluster comparable to the Trapezium Cluster and NGC6334 I(N).Comment: 10 pages, 5 figures. Accepted for publication in A&