Entanglement and nonlocality of one- and two-mode combination squeezed state

We investigate the entanglement and nonlocality properties of one- and two-mode combination squeezed vacuum state (OTCSS, with two-parameter lamda and gamma) by analyzing the logarithmic negativity and the Bell's inequality. It is found that this state exhibits larger entanglement than that of the usual two-mode squeezed vacuum state (TSVS), and that in a certain regime of lamda, the violation of Bell's inequality becomes more obvious, which indicates that the nonlocality of OTCSS can be stronger than that of TSVS. As an application of OTCSS, the quantum teleportaion is examined, which shows that there is a region spanned by lamda and gamma in which the fidelity of OTCSS channel is larger than that of TSVS.Comment: 15 pages, 7 figures, accepted by Optics communication

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.

Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM). We show that tumor-promoting macrophages are spatially proximate to GBM-associated endothelial cells (ECs), permissive for angiocrine-induced macrophage polarization. We identify ECs as one of the major sources for interleukin-6 (IL-6) expression in GBM microenvironment. Furthermore, we reveal that colony-stimulating factor-1 and angiocrine IL-6 induce robust arginase-1 expression and macrophage alternative activation, mediated through peroxisome proliferator-activated receptor-γ-dependent transcriptional activation of hypoxia-inducible factor-2α. Finally, utilizing a genetic murine GBM model, we show that EC-specific knockout of IL-6 inhibits macrophage alternative activation and improves survival in the GBM-bearing mice. These findings illustrate a vascular niche-dependent mechanism for alternative macrophage activation and cancer progression, and suggest that targeting endothelial IL-6 may offer a selective and efficient therapeutic strategy for GBM, and possibly other solid malignant tumors