Convergence and stability analysis of kolmogorov system solutions in infinite-dimensional space

© Medwell Journals, 2017.The study studied the issues of convergence and stability of some calculation system solutions for linear differential equations, namely Kolmogorov's calculation systems in infinite-dimensional space on the basis of local integrability, non-negative coefficients and diagonal dominance properties. The conditions for operators were found with which they solve some problems of these system solution convergence and stability. On the basis of the local integrability, non-negative coefficients and diagonal dominance properties the sufficient conditions were obtained which guarantee the stability and the convergence of Kolmogorov's countable system solutions. The results of the study may be applied during the analysis of technical system various models, particularly the telecommunication system models. Besides, the results of Kolmogorov's system analysis can be used for biological system modeling. The study develops the approach to the qualitative research of Kolmogorov's systems based on the distribution of differential equation qualitative theory in infinite-dimensional spaces on Kolmogorov's systems that allowed to obtain a number of new results. Strict substantiations of the statements are presented concerning the qualitative behavior of solutions for some calculation systems of linear differential equations. One may formulate similar statements for infinite reproduction and death systems which are the particular cases of Kolmogorov's systems as the results of obtained statements

ESTIMATION OF EFFICIENCY OF FROZEN-THAWED EMBRYOS TRANSFERS IN IVF CYCLES

Cryo-embryos transfer is less expensive and less aggressive method in compare with repeated ovarian stimulation and transfer of «fresh» embryos. The article presents the analysis of influence of various factors on the efficiency of cryo-embryo transfers in 118 IVF cycles. The main success criteria is the quality of thawed embryos

Treatment of fractures with plate osteosynthesis with bioactive coating

The aim. of the work was to introduce implants with bioactive coating in the practice of treatment of long tubular bones and. to assess speed of consolidation in comparison with bioinert constructions with use of clinical data, radiation and biochemical methods of examination. Use of bioactive calcium-phosphate coatings obtained by the method of microarc oxidation for the osteosynthesis of long tubular bones is accompanied by more effective consolidation of fracture area in comparison with titanium plates. In 4 months after the operation with use of bioactive implants 95,2 % of patients had. active formation and. formed callus and. only 4,8 % of patients didn't have signs of consolidation. In the same terms at the fixation by bioinert plates adhesion of fracture didn't happen in 24 % of cases. Main mechanism of positive action of bioactive implants is connected with increase of calcium depot in blood and. decrease of markers of bone resorption in the first months after their installation

Safety of Antibacterial and Antiprotozoal Medicinal Products

The experts of the Scientific Centre for Expert Evaluation of Medicinal Products analysed administrative decisions of foreign regulatory authorities on the recalls of antibacterial and antiprotozoal medicinal products and/or the need for labelling updates due to changes in the safety profile. The analysis revealed 16 decisions containing information on the following medicines registered in Russia: ertapenem, сeftriaxone, cefazolin, аmoxicillin, сefoperazone+sulbactam, piperacillin+tazobactam, сlindamycin, teicoplanin, rifampin, co-trimoxazole, hydroxychloroquine

Качество жизни при цервикальной дистонии

The aim of the study was to study the physical and psychological components regarding the quality of life of patients with cervical dystonia.Material and methods. 170 respondents were examined. The main group included 120 patients with cervical dystonia, 50 patients were included in the control group, consisting of patients with cervicalgia of various genesis. The diagnosis of cervical dystonia met uniform criteria for the diagnosis and treatment of dystonia adopted in 2011 by the European Federation of Neurological Societies and the Movement Disorders Society (European Federation of Neurological Societies / Movement Disorders Society, EFNS / MDS). In the control group, the pain syndrome of the cervical spine was caused by a degenerative process and was confirmed by X-ray examination and /or MRI. As part of our research, we determined the quality of life in men and women in both groups using the SF-36 questionnaire with a study of the parameters of physical and psychological well-being.Results and conclusion. A considerably significant effect of cervical dystonia on the somatic and mental  parameters regarding the quality of life in both men and women has been established. Significant decrease in all indicators representing the quality of life in patients with cervical dystonia was revealed compared with respondents without dystonic hyperkinesis. As a chronic disease, cervical dystonia leads to psycho-physiological stress, which significantly impairs the quality of life of patients. Significant gender differences were identified: women from the groups of cervical dystonia and cervicalgia were more often exposed to psychological deprivation and reduced physical activity than men from the same groups.Цель. Изучить физические и психологические составляющие качества жизни больных, страдающих цервикальной дистонией.Материалы и методы. Обследованы 170 респондентов: 120 пациентов с цервикальной дистонией составили основную группу, 50 человек включены в группу контроля – респонденты с цервикалгиями различного генеза. Диагноз цервикальной дистонии установлен клинически, согласно единым критериям по диагностике и лечению дистонии, принятым в 2011 г. Европейской федерацией неврологических обществ и Обществом двигательных расстройств (European Federation of Neurological Societies / Movement Disorders Society, EFNS / MDS). Болевой синдром в шейном отделе позвоночника у группы контроля был вызван дегенеративным процессом и подтвержден рентгенографическим обследованием и (или) магнитно-резонансной томографией. В рамках проводимого нами исследования определялось качество жизни у мужчин и женщин в обеих группах с помощью опросника SF-36 с изучением параметров физического и психологического благополучия.Результаты и заключение. Установлено достоверно значимое влияние цервикальной дистонии на соматические и психические параметры качества жизни как у мужчин, так и у женщин. Выявлено достоверное снижение всех показателей качества жизни у больных цервикальной дистонией по сравнению с респондентами, не имеющих дистонического гиперкинеза. Цервикальная дистония как хроническое заболевание приводит к психофизиологическому напряжению, что значительно ухудшает качество жизни больных. Выявлены достоверные гендерные внутригрупповые различия: женщины из групп цервикальной дистонии и цервикалгий в большей степени подвержены психологической депривации и снижению физической деятельности, чем мужчины из этих же групп

System Approach to the Development of Intelligent Complexes of Oncological Diagnostics

The system approach to the development of intellectual complexes in cancer diagnosis are discussed in the article. Distinctive features of this approach: the participation of pathologist at the stage of description of recognizable images (the description is based on traditional assessments of quality informative features of tumors); the set of the most similar probabilistic diagnoses is forming on the classification stage of recognition; final histological diagnosis is made by pathologist. The proposed approach has been successfully tested in clinical practice. Keywords: image processing, image description, image classification, pattern recognition, qualitative attributes of tumor images, interactive recognition, cancer diagnosis, decision support syste

Vitamin D (steroid hormone) and the nervous system diseases (literature review)

The present review aims to summarize the activities of vitamin D effects on the nervous system and to clarify a vitamin D role in brain diseases, in the pathogenesis or as a serum biomarker for the disease development and severity. Objective: correlation between chronic nervous system diseases and vitamin D level. Methods: a literature research in PubMed and in Russian electronic resources by keywords: vitamin D, brain diseases, chronic nervous system diseases. Results. Vitamin D as a neurosteroid hormone stimulates cerebral activity in both adult and embryonic brain regulates the activity of neural circuits which are responsible for locomotor, reward-dependent and emotional behavior. Patients with autism spectrum disorders, schizophrenia, Alzheimer disease, multiple sclerosis, Parkinson disease and sleep disorders have been shown to have low level of vitamin D. Discussion. Data are controversial, a further study of vitamin D hypovitaminosis significance is essential for the nervous system chronic diseases manifestation and evaluation of the vitamin D dietary supplement efficiency in patients with the nervous system pathology

Geometry and material effects in Casimir physics - Scattering theory

We give a comprehensive presentation of methods for calculating the Casimir force to arbitrary accuracy, for any number of objects, arbitrary shapes, susceptibility functions, and separations. The technique is applicable to objects immersed in media other than vacuum, to nonzero temperatures, and to spatial arrangements in which one object is enclosed in another. Our method combines each object's classical electromagnetic scattering amplitude with universal translation matrices, which convert between the bases used to calculate scattering for each object, but are otherwise independent of the details of the individual objects. This approach, which combines methods of statistical physics and scattering theory, is well suited to analyze many diverse phenomena. We illustrate its power and versatility by a number of examples, which show how the interplay of geometry and material properties helps to understand and control Casimir forces. We also examine whether electrodynamic Casimir forces can lead to stable levitation. Neglecting permeabilities, we prove that any equilibrium position of objects subject to such forces is unstable if the permittivities of all objects are higher or lower than that of the enveloping medium; the former being the generic case for ordinary materials in vacuum.Comment: 44 pages, 11 figures, to appear in upcoming Lecture Notes in Physics volume in Casimir physic

Algorithm for determining the authenticity of biomedical cell preparations containing mesenchymal stem cells

The use of mesenchymal stem cells (MSCs), which have a pronounced immunomodulatory activity, is a promising direction in the development of biomedical cell preparations (BMCPs). In oncohematology, the use of BMCPs containing MSCs is aimed at supporting hematopoiesis during cotransplantation with hematopoietic stem cells (HSCs) and suppressing immune conflicts during allogeneic unrelated transplantation and severe autoimmune processes. An obligatory stage of registration of BMCPs is confirmation of the identity of the MSC cell line (CL), which includes the establishment of morphological characteristics, evaluation of the expression of specific markers and proteins, and confirmation of the genetic stability of CL during cultivation. Determination of markers of genetic stability is possible using various methods, however, according to the recommendations of the American National Standardization Institute, the standard is the analysis of short tandem repeats (STR analysis). The purpose of the study is to develop an algorithm for determining the authenticity of BMCPs containing MSCs, including STR analysis. Material and methods. Identification of MSC cells in BMCP was performed according to the criteria of the International Society for Cell Therapy. Viable cells were counted in a Goryaev chamber. Immunophenotypic characteristics of MSCs were determined by flow cytometry. The level of production of specific proteins was assessed using enzyme immunoassay. Genetic stability markers were identified by STR analysis. Results and discussion. The methods were tested in triplicate for ten BMCP samples to confirm the reproducibility and reliability of the results. The developed algorithm for determining the authenticity of BMCP has a high accuracy, as it includes the STR analysis technique, which makes it possible to identify 19 polymorphic STR markers located on different alleles. Using the method will allow BMCP manufacturers to go through the procedure of state registration of drugs