270 research outputs found
The cerebral and systemic kinetics of thiopentone and propofol in halothane anaesthetized sheep
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsThe cerebral and systemic kinetics of intravenous thiopentone (250 mg over 2 minutes, n=5) and propofol (100 mg over 2 minutes, n=6) were determined in sheep anaesthetized with halothane (2.0%) and mechanically ventilated to an end-expired carbon dioxide tension of 40 mmHg. The sheep were previously instrumented with arterial and sagittal sinus (effluent from the brain) blood sampling catheters. Systemic kinetics were inferred from the time-course of the arterial blood concentrations, and cerebral kinetics from the time-course of the arterio-sagittal sinus concentration difference across the brain. Under halothane anaesthesia, the peak arterial concentrations of each drug occurred at the end of the two-minute infusion, and was 42.3 mg/l and 12.3 mg/l for thiopentone and propofol, respectively. Propofol had a significantly larger systemic clearance (3.19 l/min) than thiopentone (0.99 l/min). The brain concentrations of propofol equilibrated more slowly with the arterial concentrations than those of thiopentone. The extraction ratio across the brain near the end of the infusions (1.5 min) were 0.85 and 0.46 respectively. These data were also compared to analogous previously published data for initially conscious sheep. The systemic kinetics of thiopentone were little affected by halothane anaesthesia. For propofol, halothane anaesthesia was associated with a statistically significant reduction in clearance (50% of awake), a slower initial half-life (247% of awake), and the emergence of a second slower half-life in some sheep. The cerebral kinetics of both drugs were subtly altered by halothane anaesthesia.R. N. Upton, G. L. Ludbrook, C. Granthttp://www.aaic.net.au/Article.asp?D=200024
Quantum correlated twin atomic beams via photo-dissociation of a molecular Bose-Einstein condensate
We study the process of photo-dissociation of a molecular Bose-Einstein
condensate as a potential source of strongly correlated twin atomic beams. We
show that the two beams can possess nearly perfect quantum squeezing in their
relative numbers.Comment: Corrected LaTeX file layou
Few-cycle soliton propagation
Soliton propagation is usually described in the ``slowly varying envelope
approximation'' (SVEA) regime, which is not applicable for ultrashort pulses.
We present theoretical results and numerical simulations for both NLS and
parametric () ultrashort solitons in the ``generalised few-cycle
envelope approximation'' (GFEA) regime, demonstrating their altered
propagation.Comment: 4 pages, 4 figure
Noise-free scattering of the quantized electromagnetic field from a dispersive linear dielectric
We study the scattering of the quantized electromagnetic field from a linear,
dispersive dielectric using the scattering formalism for quantum fields. The
medium is modeled as a collection of harmonic oscillators with a number of
distinct resonance frequencies. This model corresponds to the Sellmeir
expansion, which is widely used to describe experimental data for real
dispersive media. The integral equation for the interpolating field in terms of
the in field is solved and the solution used to find the out field. The
relation between the in and out creation and annihilation operators is found
which allows one to calculate the S-matrix for this system. In this model, we
find that there are absorption bands, but the input-output relations are
completely unitary. No additional quantum noise terms are required.Comment: Revtex, submitted to Physical Review
Quantum-Noise Reduction in a Driven Cavity with Feedback
We show that amplitude-squeezed states may be produced by driving a feedback-controlled cavity with a coherent input signal. The feedback controls the transmissivity of one output from the cavity and is essentially equivalent to nonlinear absorption. The cavity effectively acts as a nonlinear reflector. Hence, amplitude-squeezed states with arbitrarily strong coherent intensities can be obtained
Nonclassical statistics of intracavity coupled waveguides: the quantum optical dimer
A model is proposed where two nonlinear waveguides are contained
in a cavity suited for second-harmonic generation. The evanescent wave coupling
between the waveguides is considered as weak, and the interplay between this
coupling and the nonlinear interaction within the waveguides gives rise to
quantum violations of the classical limit. These violations are particularly
strong when two instabilities are competing, where twin-beam behavior is found
as almost complete noise suppression in the difference of the fundamental
intensities. Moreover, close to bistable transitions perfect twin-beam
correlations are seen in the sum of the fundamental intensities, and also the
self-pulsing instability as well as the transition from symmetric to asymmetric
states display nonclassical twin-beam correlations of both fundamental and
second-harmonic intensities. The results are based on the full quantum Langevin
equations derived from the Hamiltonian and including cavity damping effects.
The intensity correlations of the output fields are calculated
semi-analytically using a linearized version of the Langevin equations derived
through the positive-P representation. Confirmation of the analytical results
are obtained by numerical simulations of the nonlinear Langevin equations
derived using the truncated Wigner representation.Comment: 15 pages, 8 figures, submitted to Phys. Rev.
Systematic review of economic evaluations and cost analyses of guideline implementation strategies
Objectives To appraise the quality of economic studies undertaken as part of evaluations of guideline implementation strategies; determine their resources use; and recommend methods to improve future studies. Methods Systematic review of economic studies undertaken alongside robust study designs of clinical guideline implementation strategies published (1966-1998). Studies assessed against the BMJ economic evaluations guidelines for each stage of the guideline process (guideline development, implementation and treatment). Results 235 studies were identified, 63 reported some information on cost. Only 3 studies provided evidence that their guideline was effective and efficient. 38 reported the treatment costs only, 12 implementation and treatment costs, 11 implementation costs alone, and two guideline development, implementation and treatment costs. No study gave reasonably complete information on costs. Conclusions Very few satisfactory economic evaluations of guideline implementation strategies have been performed. Current evaluations have numerous methodological defects and rarely consider all relevant costs and benefits. Future evaluations should focus on evaluating the implementation of evidence based guidelines. Keywords: Cost-effectiveness analysis, physician (or health care professional) behaviour, practice guidelines, quality improvement, systematic review.Peer reviewedAuthor versio
Renal Foreign Bodies
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67109/2/10.1177_000992286900800511.pd
Bose-Einstein condensate collapse: a comparison between theory and experiment
We solve the Gross-Pitaevskii equation numerically for the collapse induced
by a switch from positive to negative scattering lengths. We compare our
results with experiments performed at JILA with Bose-Einstein condensates of
Rb-85, in which the scattering length was controlled using a Feshbach
resonance. Building on previous theoretical work we identify quantitative
differences between the predictions of mean-field theory and the results of the
experiments. Besides the previously reported difference between the predicted
and observed critical atom number for collapse, we also find that the predicted
collapse times systematically exceed those observed experimentally. Quantum
field effects, such as fragmentation, that might account for these
discrepancies are discussed.Comment: 4 pages, 2 figure
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