In situ conversion monitoring of styrene emulsion polymerization by deconvolution of a single reference band near 1,000 cm −1

International audienc

On the Exploitation of Optical Signal from Raman Spectroscopy for In-Situ Conversion Monitoring of Emulsion Polymerization

Présentation PosterInternational audienc

In situ monitoring of Emulsion Polymerization using Raman Spectroscopy

International audienc

Analyse vibrationnelle at-line/on-line en milieu industriel

National audienceFrom a technological point of view, vibrational spectroscopies techniques have evolved greatly in recent years. They are faster, have better spectral and spatial resolutions and are more sensitive. In addition, when combined with statistical analysis methods, they can be used for at-line/on-line measurements with times compatible with industrial processes. These technological developments (more powerful sources, more sensitive detectors, use of optical fibers, etc.) lead to the miniaturization of instruments, which can now be used in industrial or hostile environments. The miniaturization of measurement systems often results in less performance than on laboratory devices. It is therefore necessary to carry out a study on samples taken from the industrial process in order to identify the spectroscopic parameter(s) related to the physico-chemical properties of interest and then to build a model adapted to the lower performance of the onsite equipment. It is this compromise of performance of the sensor/efficiency/price that must be optimized.D'un point de vue technologique, les techniques de spectroscopies vibrationnelles ont fortement évolué ces dernières années. Elles sont plus rapides, ont de meilleures résolutions spectrale et spatiale et sont plus sensibles. De plus, associées à des méthodes d'analyses statistiques, elles permettent des mesures at-line/on-line avec des temps compatibles avec les procédés industriels. Ces évolutions technologiques (sources plus puissantes, détecteurs plus sensibles, utilisation de fibres optiques, etc.) conduisent aussi à la miniaturisation des instruments qui peuvent désormais être utilisés dans des environnements industriels ou hostiles. La miniaturisation des systèmes de mesure entraine des performances souvent moindres que sur des appareils de laboratoire. Il est donc nécessaire de réaliser une étude amont sur des prélèvements du procédé industriel afin d'identifier le(s) paramètre(s) spectroscopique(s) lié(s) aux propriétés physico-chimiques d'intérêt et ensuite de construire un modèle pouvant être adapté aux performances moindres de l'équipement sur site. C'est ce compromis performance du capteur/efficacité/prix qu'il faut optimise

Discovery of <i>N</i>‑(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro‑4<i>H</i>‑thieno[2,3‑<i>c</i>]pyran-2-yl)‑l<i>H</i>‑pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

Cystic fibrosis (CF) is caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Orkambi, it has been shown that CFTR function can be partially restored by administering one or more small molecules. These molecules aim at either enhancing the amount of CFTR on the cell surface (correctors) or at improving the gating function of the CFTR channel (potentiators). Here we describe the discovery of a novel potentiator GLPG1837, which shows enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor, the first marketed potentiator. The optimization of potency, efficacy, and pharmacokinetic profile will be described