Measuring Biological Aptitude Omics QA/QC Rubrics

Sequencing, Proteomics, and Metabolomics QA/QC Scoring Rubrics for the DARPA Measuring Biological Aptitude Program, associated with "Efforts to enhance reproducibility in a human performance research project" by J.A. Drocco, et al. (2023).</p

Quantifying the sorting efficiency of self-propelled run-and-tumble swimmers by geometrical ratchets

Suitable asymmetric microstructures can be used to control the direction of motion in microorganism populations. This rectification process makes it possible to accumulate swimmers in a region of space or to sort different swimmers. Here we study numerically how the separation process depends on the specific motility strategies of the microorganisms involved. Crucial properties such as the separation effi ciency and the separation time for two bacterial strains are precisely defined and evaluated. In particular, the sorting of two bacterial populations inoculated in a box consisting of a series of chambers separated by columns of asymmetric obstacles is investigated. We show how the sorting e fficiency is enhanced by these obstacles and conclude that this kind of sorting can be effi ciently used even when the involved populations differ only in one aspect of their swimming strategy