Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells

Suppressors of cytokine signaling (SOCS) are a family of eight proteins that negatively regulate JAK-STAT signaling in cells that utilize this pathway to respond to extracellular stimuli. SOCS are best known for attenuating cytokine signaling in the immune system. However, they are also expressed in many other cell types, including pancreatic β-cells where there is considerable interest in harnessing SOCS molecules to prevent cytokine-mediated apoptosis during diabetes and allogeneic transplantation. Apart from their potential as therapeutic targets, SOCS molecules play a central role for regulating important functions in β-cells, including growth, glucose sensing and insulin secretion. This review will discuss SOCS proteins as central regulators for diverse cellular processes important for normal β-cell function as well as their protective anti-apoptotic effects during β-cell stress

Star Cluster Candidates in M81

We present a catalog of extended objects in the vicinity of M81 based a set of 24 Hubble Space Telescope Advanced Camera for Surveys (ACS) Wide Field Camera (WFC) F814W (I-band) images. We have found 233 good globular cluster candidates; 92 candidate HII regions, OB associations, or diffuse open clusters; 489 probable background galaxies; and 1719 unclassified objects. We have color data from ground-based g- and r-band MMT Megacam images for 79 galaxies, 125 globular cluster candidates, 7 HII regions, and 184 unclassified objects. The color-color diagram of globular cluster candidates shows that most fall into the range 0.25 < g-r < 1.25 and 0.5 < r-I < 1.25, similar to the color range of Milky Way globular clusters. Unclassified objects are often blue, suggesting that many of them are likely to be HII regions and open clusters, although a few galaxies and globular clusters may be among them.Comment: 35 pages, 11 figures, submitted to A

The Properties of Poor Groups of Galaxies: III. The Galaxy Luminosity Function

We obtain R-band photometry for galaxies in six nearby poor groups for which we have spectroscopic data, including 328 new galaxy velocities. For the five groups with luminous X-ray halos, the composite group galaxy luminosity function (GLF) is fit adequately by a Schechter function with Mstar = -21.6 +/- 0.4 + 5log h and alpha = -1.3 +/- 0.1. We also find that (1) the ratio of dwarfs to giants is significantly larger for the five groups with luminous X-ray halos than for the one marginally X-ray detected group, (2) the composite GLF for the luminous X-ray groups is consistent in shape with that for rich clusters, (3) the composite group GLF rises more steeply at the faint end than that of the field, (4) the shape difference between the field and composite group GLF's results mostly from the population of non-emission line galaxies, whose dwarf-to-giant ratio is larger in the denser group environment than in the field, and (5) the non-emission line dwarfs are more concentrated about the group center than the non-emission line giants. This last result indicates that the dwarfs and giants occupy different orbits (i.e., have not mixed completely) and suggests that the populations formed at a different times. Our results show that the shape of the GLF varies with environment and that this variation is due primarily to an increase in the dwarf-to-giant ratio of quiescent galaxies in higher density regions, at least up to the densities characteristic of X-ray luminous poor groups. This behavior suggests that, in some environments, dwarfs are more biased than giants with respect to dark matter. This trend conflicts with the prediction of standard biased galaxy formation models. (Abridged)Comment: 36 pages, AASLaTeX with 8 figures. Table 1 also available at http://atropos.as.arizona.edu/aiz/papers/all_grp_lf_ascii.dat.final . To appear in Ap

The Role of Autophagy in iNKT Cell Development

CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses. Thymic development and function of iNKT cells are regulated by many different cellular processes, including autophagy, a self-degradation mechanism. In this mini review, we discuss the current understanding of how autophagy regulates iNKT cell development and effector lineage differentiation. Importantly, we propose that iNKT cell development is tightly controlled by metabolic reprogramming

A Catalogue of Morphologically Classified Galaxies from the Sloan Digital Sky Survey: North Equatorial Region

We present a catalogue of morphologically classified bright galaxies in the north equatorial stripe (230 deg$^2$) derived from the Third Data Release of the Sloan Digital Sky Survey (SDSS). Morphological classification is performed by visual inspection of images in the $g$ band. The catalogue contains 2253 galaxies complete to a magnitude limit of $r=16$ after Galactic extinction correction, selected from 2658 objects that are judged as extended in the photometric catalogue in the same magnitude limit. 1866 galaxies in our catalogue have spectroscopic information. A brief statistical analysis is presented for the frequency of morphological types and mean colours in the catalogue. A visual inspection of the images reveals that the rate of interacting galaxies in the local Universe is approximately 1.5% in the $r\le16$ sample. A verification is made for the photometric catalogue generated by the SDSS, especially as to its bright end completeness.Comment: Accepted for publication in Astronomical Journal. Table 2 available at http://www.icrr.u-tokyo.ac.jp/~fukugita/MCGpaper/table2.tx

Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

OBJECTIVE: In part, activation of invariant natural killer T (iNKT)-cells with the superagonist alpha-galactosylceramide (alpha-GalCer) inhibits the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice by inducing the downstream differentiation of antigen-presenting dendritic cells (DCs) to an immunotolerogenic state. However, in other systems iNKT-cell activation has an adjuvant-like effect that enhances rather than suppresses various immunological responses. Thus, we tested whether in some circumstances genetic variation would enable activated iNKT-cells to support rather than inhibit type 1 diabetes development. RESEARCH DESIGN AND METHODS: We tested whether iNKT-conditioned DCs in NOD mice and a major histocompatibility complex-matched C57BL/6 (B6) background congenic stock differed in capacity to inhibit type 1 diabetes induced by the adoptive transfer of pathogenic AI4 CD8 T-cells. RESULTS: Unlike those of NOD origin, iNKT-conditioned DCs in the B6 background stock matured to a state that actually supported rather than inhibited AI4 T-cell-induced type 1 diabetes. The induction of a differing activity pattern of T-cell costimulatory molecules varying in capacity to override programmed death-ligand-1 inhibitory effects contributes to the respective ability of iNKT-conditioned DCs in NOD and B6 background mice to inhibit or support type 1 diabetes development. Genetic differences inherent to both iNKT-cells and DCs contribute to their varying interactions in NOD and B6.H2(g7) mice. CONCLUSIONS: This great variability in the interactions between iNKT-cells and DCs in two inbred mouse strains should raise a cautionary note about considering manipulation of this axis as a potential type 1 diabetes prevention therapy in genetically heterogeneous humans

Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes

The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response. A multitudinous group of lymphoid lineage cells does not fit the conventional lymphocyte paradigm; it is the unconventional lymphocytes. Unconventional lymphocytes—here called innate/innate-like lymphocytes, include those that express rearranged antigen receptor genes and those that do not. Even though the innate/innate-like lymphocytes express rearranged, adaptive antigen-specific receptors, they behave like innate immune cells, which allows them to integrate sensory signals from the innate immune system and relay that umwelt to downstream innate and adaptive effector responses. Here, we review natural killer T cells and mucosal-associated invariant T cells—two prototypic innate-like T lymphocytes, which sense their local environment and relay that umwelt to downstream innate and adaptive effector cells to actuate an appropriate host response that confers immunity to infectious agents

Deletion of Vβ3

In both humans and NOD mice, type 1 diabetes (T1D) develops from the autoimmune destruction of pancreatic beta cells by T cells. Interactions between both helper CD

Galaxy and Mass Assembly (GAMA): ugriz galaxy luminosity functions

Galaxy and Mass Assembly (GAMA) is a project to study galaxy formation and evolution, combining imaging data from ultraviolet to radio with spectroscopic data from the AAOmega spectrograph on the Anglo-Australian Telescope. Using data from Phase 1 of GAMA, taken over three observing seasons, and correcting for various minor sources of incompleteness, we calculate galaxy luminosity functions (LFs) and their evolution in the ugriz passbands. At low redshift, z < 0.1, we find that blue galaxies, defined according to a magnitude-dependent but non-evolving colour cut, are reasonably well fitted over a range of more than 10 magnitudes by simple Schechter functions in all bands. Red galaxies, and the combined blue plus red sample, require double power-law Schechter functions to fit a dip in their LF faintwards of the characteristic magnitude M* before a steepening faint end. This upturn is at least partly due to dust-reddened disc galaxies. We measure the evolution of the galaxy LF over the redshift range 0.002 < z < 0.5 both by using a parametric fit and by measuring binned LFs in redshift slices. The characteristic luminosity L* is found to increase with redshift in all bands, with red galaxies showing stronger luminosity evolution than blue galaxies. The comoving number density of blue galaxies increases with redshift, while that of red galaxies decreases, consistent with prevailing movement from blue cloud to red sequence. As well as being more numerous at higher redshift, blue galaxies also dominate the overall luminosity density beyond redshifts z≃ 0.2. At lower redshifts, the luminosity density is dominated by red galaxies in the riz bands, and by blue galaxies in u and g