Editor\u27s Note, Vol. 57, No. 3

Greetings from the Editors of Court Review! We are all heading into the last quarter of yet another year of pandemic, and our courts surely feel the brunt of it all. As judges confront the everyday problems of ordinary Americans, the ongoing stress and management challenges are taking its toll. We are always committed to providing valuable content and information to help ease the burden. Congratulations to you for all the hard work amidst an uncertain time. This issue presents the annual return of our U.S. Supreme Court review of notable civil cases from the 2020 Term ending last June 30. Thomas M. Fisher, Solicitor General of the State of Indiana, and four-time High Court contender, again adroitly outlines a challenging set of civil cases. We all benefit from this formidable round-up and discussion of our current legal landscape

Editor\u27s Note, Vol. 58, No. 3

Greetings from the Editors of Court Review! Even though we are all thinking that the pandemic is past, our courts are still working on the aftereffects. Overdue jury trials, long awaited hearings, and the pent-up demand for attention among our litigants keeps our caseloads active and urgent. As judges confront the everyday problems of ordinary Americans, we are always committed to providing valuable content and information to help ease the burden. Congratulations to you for all the hard work amidst an uncertain time

Cost-Effectiveness of Automated Digital Microscopy for Diagnosis of Active Tuberculosis.

BACKGROUND: Automated digital microscopy has the potential to improve the diagnosis of tuberculosis (TB), particularly in settings where molecular testing is too expensive to perform routinely. The cost-effectiveness of TB diagnostic algorithms using automated digital microscopy remains uncertain. METHODS: Using data from a demonstration study of an automated digital microscopy system (TBDx, Applied Visual Systems, Inc.), we performed an economic evaluation of TB diagnosis in South Africa from the health system perspective. The primary outcome was the incremental cost per new TB diagnosis made. We considered costs and effectiveness of different algorithms for automated digital microscopy, including as a stand-alone test and with confirmation of positive results with Xpert MTB/RIF ('Xpert', Cepheid, Inc.). Results were compared against both manual microscopy and universal Xpert testing. RESULTS: In settings willing to pay $2000 per incremental TB diagnosis, universal Xpert was the preferred strategy. However, where resources were not sufficient to support universal Xpert, and a testing volume of at least 30 specimens per day could be ensured, automated digital microscopy with Xpert confirmation of low-positive results could facilitate the diagnosis of 79-84$1280 per incremental TB diagnosis (95% uncertainty range, UR: $340-$3440) in the base case, but improved under conditions likely reflective of many settings in sub-Saharan Africa: $677 per diagnosis (95$450-$935) when sensitivity of manual smear microscopy was lowered to 0.5, and$956 per diagnosis (95% UR: $40-$2910) when the prevalence of multidrug-resistant TB was lowered to 1%. CONCLUSIONS: Although universal Xpert testing is the preferred algorithm for TB diagnosis when resources are sufficient, automated digital microscopy can identify the majority of cases and halve the cost of diagnosis and treatment when resources are more scarce and multidrug-resistant TB is not common

Photoproduction at collider energies: from RHIC and HERA to the LHC

We present the mini-proceedings of the workshop on ``Photoproduction at collider energies: from RHIC and HERA to the LHC'' held at the European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT*, Trento) from January 15 to 19, 2007. The workshop gathered both theorists and experimentalists to discuss the current status of investigations of high-energy photon-induced processes at different colliders (HERA, RHIC, and Tevatron) as well as preparations for extension of these studies at the LHC. The main physics topics covered were: (i) small-$x$ QCD in photoproduction studies with protons and in electromagnetic (aka. ultraperipheral) nucleus-nucleus collisions, (ii) hard diffraction physics at hadron colliders, and (iii) photon-photon collisions at very high energies: electroweak and beyond the Standard Model processes. These mini-proceedings consist of an introduction and short summaries of the talks presented at the meeting

Functional, structural and phylogenetic analysis of domains underlying the Al sensitivity of the aluminum-activated malate/anion transporter, TaALMT1.

Triticum aestivum aluminum-activated malate transporter (TaALMT1) is the founding member of a unique gene family of anion transporters (ALMTs) that mediate the efflux of organic acids. A small sub-group of root-localized ALMTs, including TaALMT1, is physiologically associated with in planta aluminum (Al) resistance. TaALMT1 exhibits significant enhancement of transport activity in response to extracellular Al. In this study, we integrated structure–function analyses of structurally altered TaALMT1 proteins expressed in Xenopus oocytes with phylogenic analyses of the ALMT family. Our aim is to re-examine the role of protein domains in terms of their potential involvement in the Al-dependent enhancement (i.e. Al-responsiveness) of TaALMT1 transport activity, as well as the roles of all its 43 negatively charged amino acid residues. Our results indicate that the N-domain, which is predicted to form the conductive pathway, mediates ion transport even in the absence of the C-domain. However, segments in both domains are involved in Al3+ sensing. We identified two regions, one at the N-terminus and a hydrophobic region at the C-terminus, that jointly contribute to the Al-response phenotype. Interestingly, the characteristic motif at the N-terminus appears to be specific for Al-responsive ALMTs. Our study highlights the need to include a comprehensive phylogenetic analysis when drawing inferences from structure–function analyses, as a significant proportion of the functional changes observed for TaALMT1 are most likely the result of alterations in the overall structural integrity of ALMT family proteins rather than modifications of specific sites involved in Al3+ sensing

AMI observations of unmatched Planck ERCSC LFI sources at 15.75 GHz

The Planck Early Release Compact Source Catalogue includes 26 sources with no obvious matches in other radio catalogues (of primarily extragalactic sources). Here we present observations made with the Arcminute Microkelvin Imager Small Array (AMI SA) at 15.75 GHz of the eight of the unmatched sources at declination > +10 degrees. Of the eight, four are detected and are associated with known objects. The other four are not detected with the AMI SA, and are thought to be spurious.Comment: 6 pages, 5 figures, 4 table

Properties of the Volume Operator in Loop Quantum Gravity II: Detailed Presentation

The properties of the Volume operator in Loop Quantum Gravity, as constructed by Ashtekar and Lewandowski, are analyzed for the first time at generic vertices of valence greater than four. The present analysis benefits from the general simplified formula for matrix elements of the Volume operator derived in gr-qc/0405060, making it feasible to implement it on a computer as a matrix which is then diagonalized numerically. The resulting eigenvalues serve as a database to investigate the spectral properties of the volume operator. Analytical results on the spectrum at 4-valent vertices are included. This is a companion paper to arXiv:0706.0469, providing details of the analysis presented there.Comment: Companion to arXiv:0706.0469. Version as published in CQG in 2008. More compact presentation. Sign factor combinatorics now much better understood in context of oriented matroids, see arXiv:1003.2348, where also important remarks given regarding sigma configurations. Subsequent computations revealed some minor errors, which do not change qualitative results but modify some numbers presented her

Fanny Copeland and the geographical imagination

Raised in Scotland, married and divorced in the English south, an adopted Slovene, Fanny Copeland (1872 – 1970) occupied the intersection of a number of complex spatial and temporal conjunctures. A Slavophile, she played a part in the formation of what subsequently became the Kingdom of Yugoslavia that emerged from the First World War. Living in Ljubljana, she facilitated the first ‘foreign visit’ (in 1932) of the newly formed Le Play Society (a precursor of the Institute of British Geographers) and guided its studies of Solčava (a then ‘remote’ Alpine valley system) which, led by Dudley Stamp and commended by Halford Mackinder, were subsequently hailed as a model for regional studies elsewhere. Arrested by the Gestapo and interned in Italy during the Second World War, she eventually returned to a socialist Yugoslavia, a celebrated figure. An accomplished musician, linguist, and mountaineer, she became an authority on (and populist for) the Julian Alps and was instrumental in the establishment of the Triglav National Park. Copeland’s role as participant observer (and protagonist) enriches our understanding of the particularities of her time and place and illuminates some inter-war relationships within G/geography, inside and outside the academy, suggesting their relative autonomy in the production of geographical knowledge

Social impacts and life cycle assessment: proposals for methodological development for SMEs in the European food and drink sector

Purpose: Small and medium enterprises (SMEs) account for 99 % of companies operating in the European food and drink industry and, often, are part of highly fragmented and complex food chains. The article focuses on the development of a social impact assessment methodology for SMEs in selected food and drink products as part of the EU-FP7 SENSE research project. The proposed methodology employs a top-down and bottom-up approach and focuses on labour rights/working conditions along the product supply chain as the key social impact indicator, limiting key stakeholder classification to workers/employees and local communities impacted by the production process. Problems related to this emerging field are discussed, and questions for further research are expounded. Methods: The article reviews both academic and 'grey' literature on life cycle assessment (LCA) and its relationship to social LCA (S-LCA) and SMEs at the beginning of 2013 and includes case study evidence from the food sector. A pilot questionnaire survey sent to European food and drink sector SMEs and trade associations (as partners in the research project) about their knowledge, experience and engagement with social impacts is presented. Proposals are elaborated for a social impact assessment methodology that identifies the key data for SMEs to collect. Results and discussion: The literature reveals the complexity of the S-LCA approach as it aims to unite disparate and often conflicting interests. Findings from the pilot questionnaire are discussed. Using a top-down and bottom-up approach, the proposed methodology assesses data from SMEs along the supply chain in order to gauge social improvements in the management of labour-related issues for different product sectors. Issues relating to the 'attributional' choice of a social impact indicator and key stakeholder categories are discussed. How 'scoring' is interpreted and reported and what the intended effect of its use will be are also elaborated upon. Conclusions: Whilst recognising the difficulty of devising a robust social impact assessment for SMEs in the food and drink sector, it is argued that the proposed methodology makes a useful contribution in this fast-emerging field

Properties of the Volume Operator in Loop Quantum Gravity I: Results

We analyze the spectral properties of the volume operator of Ashtekar and Lewandowski in Loop Quantum Gravity, which is the quantum analogue of the classical volume expression for regions in three dimensional Riemannian space. Our analysis considers for the first time generic graph vertices of valence greater than four. Here we find that the geometry of the underlying vertex characterizes the spectral properties of the volume operator, in particular the presence of a `volume gap' (a smallest non-zero eigenvalue in the spectrum) is found to depend on the vertex embedding. We compute the set of all non-spatially diffeomorphic non-coplanar vertex embeddings for vertices of valence 5--7, and argue that these sets can be used to label spatial diffeomorphism invariant states. We observe how gauge invariance connects vertex geometry and representation properties of the underlying gauge group in a natural way. Analytical results on the spectrum on 4-valent vertices are included, for which the presence of a volume gap is proved. This paper presents our main results; details are provided by a companion paper arXiv:0706.0382v1.Comment: 36 pages, 7 figures, LaTeX. See also companion paper arXiv:0706.0382v1. Version as published in CQG in 2008. See arXiv:1003.2348 for important remarks regarding the sigma configurations. Subsequent computations have revealed some minor errors, which do not change the qualitative results but modify some of the numbers presented her