426 research outputs found
Determination of diaphragm opening-times and use of diaphragm particle traps in a hypersonic shock tube
Determination of diaphragm opening-times and use of diaphragm particle traps in hypersonic shock tub
Lava channel formation during the 2001 eruption on Mount Etna: evidence for mechanical erosion
We report the direct observation of a peculiar lava channel that was formed
near the base of a parasitic cone during the 2001 eruption on Mount Etna.
Erosive processes by flowing lava are commonly attributed to thermal erosion.
However, field evidence strongly suggests that models of thermal erosion cannot
explain the formation of this channel. Here, we put forward the idea that the
essential erosion mechanism was abrasive wear. By applying a simple model from
tribology we demonstrate that the available data agree favorably with our
hypothesis. Consequently, we propose that erosional processes resembling the
wear phenomena in glacial erosion are possible in a volcanic environment.Comment: accepted for publication in Physical Review Letter
Formation of Structure in Snowfields: Penitentes, Suncups, and Dirt Cones
Penitentes and suncups are structures formed as snow melts, typically high in
the mountains. When the snow is dirty, dirt cones and other structures can form
instead. Building on previous field observations and experiments, this work
presents a theory of ablation morphologies, and the role of surface dirt in
determining the structures formed. The glaciological literature indicates that
sunlight, heating from air, and dirt all play a role in the formation of
structure on an ablating snow surface. The present work formulates a
mathematical model for the formation of ablation morphologies as a function of
measurable parameters. The dependence of ablation morphologies on weather
conditions and initial dirt thickness are studied, focusing on the initial
growth of perturbations away from a flat surface. We derive a single-parameter
expression for the melting rate as a function of dirt thickness, which agrees
well with a set of measurements by Driedger. An interesting result is the
prediction of a dirt-induced travelling instability for a range of parameters.Comment: 28 pages, 13 figure
1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), several analogues were identified with micromolar activity through targeted displacement of bound water molecules in the active site. Since the TDZ analogues showed reduced promiscuity compared to their 2,4-dianilinopyrimidine counter parts, they represent starting points for development of highly selective kinase inhibitors
Canopy-scale biophysical controls of transpiration and evaporation in the Amazon Basin.
Canopy and aerodynamic conductances (gC and gA) are two of the key land surface biophysical variables that control the land surface response of land surface schemes in climate models. Their representation is crucial for predicting transpiration (λET) and evaporation (λEE) flux components of the terrestrial latent heat flux (λE), which has important implications for global climate change and water resource management. By physical integration of radiometric surface temperature (TR) into an integrated framework of the Penman?Monteith and Shuttleworth?Wallace models, we present a novel approach to directly quantify the canopy-scale biophysical controls on λET and λEE over multiple plant functional types (PFTs) in the Amazon Basin. Combining data from six LBA (Large-scale Biosphere-Atmosphere Experiment in Amazonia) eddy covariance tower sites and a TR-driven physically based modeling approach, we identified the canopy-scale feedback-response mechanism between gC, λET, and atmospheric vapor pressure deficit (DA), without using any leaf-scale empirical parameterizations for the modeling. The TR-based model shows minor biophysical control on λET during the wet (rainy) seasons where λET becomes predominantly radiation driven and net radiation (RN) determines 75 to 80 % of the variances of λET. However, biophysical control on λET is dramatically increased during the dry seasons, and particularly the 2005 drought year, explaining 50 to 65 % of the variances of λET, and indicates λET to be substantially soil moisture driven during the rainfall deficit phase. Despite substantial differences in gA between forests and pastures, very similar canopy?atmosphere "coupling" was found in these two biomes due to soil moisture-induced decrease in gC in the pasture. This revealed the pragmatic aspect of the TR-driven model behavior that exhibits a high sensitivity of gC to per unit change in wetness as opposed to gA that is marginally sensitive to surface wetness variability. Our results reveal the occurrence of a significant hysteresis between λET and gC during the dry season for the pasture sites, which is attributed to relatively low soil water availability as compared to the rainforests, likely due to differences in rooting depth between the two systems. Evaporation was significantly influenced by gA for all the PFTs and across all wetness conditions. Our analytical framework logically captures the responses of gC and gA to changes in atmospheric radiation, DA, and surface radiometric temperature, and thus appears to be promising for the improvement of existing land?surface?atmosphere exchange parameterizations across a range of spatial scales
Textural variations in Neogene pelagic carbonate ooze at DSDP Site 593, southern Tasman Sea, and their paleoceanographic implications
Changes in Neogene sediment texture in pelagic carbonate-rich oozes on the Challenger Plateau, southern Tasman Sea, are used to infer changes in depositional paleocurrent velocities. The most obvious record of textural change is in the mud:sand ratio. Increases in the sand content are inferred to indicate a general up-core trend towards increasing winnowing of sediments resulting from increasing flow velocity of Southern Component Intermediate Water (SCIW), the forerunner of Antarctic Intermediate Water. In particular, the intervals c. 19-14.5 Ma, c. 9.5-8 Ma, and after 5 Ma are suggested to be times of increased SCIW velocity and strong sediment winnowing. Within the mud fraction, the fine silt to coarse clay sizes from 15.6 to 2 µm make the greatest contribution to the sediments and are composed of nannofossil plates. During extreme winnowing events it is the fine silt to very coarse clay material (13-3 µm) within this range that is preferentially removed, suggesting the 10 µm cohesive silt boundary reported for siliciclastic sediments does not apply to calcitic skeletal grains. The winnowed sediment comprises coccolithophore placoliths and spheres, represented by a mode at 4-7 µm.
Further support for seafloor winnowing is gained from the presence in Hole 593 of a condensed sedimentary section from c. 18 to 14 Ma where the sand content increases to c. 20% of the bulk sample. Associated with the condensed section is a 6 m thick orange unit representing sediments subjected to particularly oxygen-rich, late early to early middle Miocene SCIW. Together these are inferred to indicate increased SCIW velocity resulting in winnowed sediment associated with faster arrival of oxygen-rich surface water subducted to form SCIW. Glacial development of Antarctica has been recorded from many deep-sea sites, with extreme glacials providing the mechanism to increase watermass flow. Miocene glacial zones Mi1b-Mi6 are identified in an associated oxygen isotope record from Hole 593, and correspond with times of particularly invigorated paleocirculation, bottom winnowing, and sediment textural changes
Canopy-scale biophysical controls on transpiration and evaporation in the Amazon Basin
Canopy and aerodynamic conductances (gC and gA) are two of the key land surface biophysical variables that control the land surface response of land surface schemes in climate models. Their representation is crucial for predicting transpiration (?ET) and evaporation (?EE) flux components of the terrestrial latent heat flux (?E), which has important implications for global climate change and water resource management. By physical integration of radiometric surface temperature (TR) into an integrated framework of the Penman?Monteith and Shuttleworth?Wallace models, we present a novel approach to directly quantify the canopy-scale biophysical controls on ?ET and ?EE over multiple plant functional types (PFTs) in the Amazon Basin. Combining data from six LBA (Large-scale Biosphere-Atmosphere Experiment in Amazonia) eddy covariance tower sites and a TR-driven physically based modeling approach, we identified the canopy-scale feedback-response mechanism between gC, ?ET, and atmospheric vapor pressure deficit (DA), without using any leaf-scale empirical parameterizations for the modeling. The TR-based model shows minor biophysical control on ?ET during the wet (rainy) seasons where ?ET becomes predominantly radiation driven and net radiation (RN) determines 75 to 80?% of the variances of ?ET. However, biophysical control on ?ET is dramatically increased during the dry seasons, and particularly the 2005 drought year, explaining 50 to 65?% of the variances of ?ET, and indicates ?ET to be substantially soil moisture driven during the rainfall deficit phase. Despite substantial differences in gA between forests and pastures, very similar canopy?atmosphere "coupling" was found in these two biomes due to soil moisture-induced decrease in gC in the pasture. This revealed the pragmatic aspect of the TR-driven model behavior that exhibits a high sensitivity of gC to per unit change in wetness as opposed to gA that is marginally sensitive to surface wetness variability. Our results reveal the occurrence of a significant hysteresis between ?ET and gC during the dry season for the pasture sites, which is attributed to relatively low soil water availability as compared to the rainforests, likely due to differences in rooting depth between the two systems. Evaporation was significantly influenced by gA for all the PFTs and across all wetness conditions. Our analytical framework logically captures the responses of gC and gA to changes in atmospheric radiation, DA, and surface radiometric temperature, and thus appears to be promising for the improvement of existing land?surface?atmosphere exchange parameterizations across a range of spatial scales
Transcending the MAX phases concept of nanolaminated early transition metal carbides/nitrides -- the ZIA phases
A new potential class of nanolaminated and structurally complex materials,
herein conceived as the Zigzag IntermetAllic (ZIA) phases, is proposed. A study
of the constituent phases of a specific Nb--Si--Ni intermetallic alloy revealed
that its ternary H-phase, \textit{i.e.}, the NbSiNi intermetallic
compound (IMC), is a crystalline solid with the close-packed \textit{fcc}
Bravais lattice, the 312 MAX phase stoichiometry and a layered atomic
arrangement that may define an entire class of nanolaminated IMCs analogous to
the nanolaminated ceramic compounds known today as the MAX phases. The electron
microscopy investigation of the NbSiNi compound -- the first
candidate ZIA phase -- revealed a remarkable structural complexity, as its
ordered unit cell is made of 96 atoms. The ZIA phases extend the concept of
nanolaminated crystalline solids well beyond the MAX phases family of early
transition metal carbides/nitrides, most likely broadening the spectrum of
achievable material properties into domains typically not covered by the MAX
phases. Furthermore, this work uncovers that both families of nanolaminated
crystalline solids, \textit{i.e.}, the herein introduced \textit{fcc} ZIA
phases and all known variants of the \textit{hcp} MAX phases, obey the same
overarching stoichiometric rule , where and are integers
ranging from 1 to 6
Host-directed therapy, an untapped opportunity for antimalarial intervention
Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases caused by viruses and intracellular bacteria, but its implementation in the context of parasitic diseases has received less attention. Here, we provide a brief overview of this field and advocate HDT as a promising strategy for antimalarial intervention based on untapped targets. HDT provides a basis from which repurposed drugs could be rapidly deployed and is likely to strongly limit the emergence of resistance. This strategy can be applied to any intracellular pathogen and is particularly well placed in situations in which rapid identification of treatments is needed, such as emerging infections and pandemics, as starkly illustrated by the current COVID-19 crisis.Ling Wei, Jack Adderley, Didier Leroy, David H. Drewry, Danny W. Wilson, Alexis Kaushansky and Christian Doeri
- …