Evaluation of the efficacy of Shiva modaka on Hematological, Biochemical and Immunological Parameters in the management of malnutrition among school going children

Malnutrition is an issue of global dimensions affecting all ages. Malnutrition in children is common in early age especially during infancy and weaning. However, it also prevails during early schooling. In adults and elderly it is studied as under Protein Energy Malnutrition. It has not only short term adverse effects but also exhibits long term sustained and progressive effects. Kuposhana/Bala Shosha is explained in the Ayurveda literatures and elaborate therapeutic interventions are also described. The disease Karshya also applies to this condition. Shiva Modaka, a drug described under Bala Roga seems to act on vide dimensions of pediatric health with indications in common pediatric ailments too. The present clinical study is an effort to evaluate the efficacy of the said drug on hematological, biochemical and immunological parameters in Malnutrition in school going children

Performance Analysis of CMOS Flip-flops

Low power has emerged in today’s electronic industry. CMOS technology is best known for low power consumption, which makes the device more reliable, efficient & portable. This paper presents the comparative analysis of CMOS flip-flops for power & speed using analog simulation, and the results are discussed. DOI: 10.17762/ijritcc2321-8169.150614

A Critical Review on the Concept of the Garbhanga Vikruti with special reference to Teratogenicity

The health of the nation depends on the health of its citizens. Despite the advancements in diagnostic techniques and therapeutic interventions, medical science has failed to keep the incidence of congenital malformations under control. Throughout the history, the birth of malformed infant features has been well documented. Data reveals that 3 to 5% of all births result in congenital malformations, 20 to 30% of all infant deaths are due to genetic disorders and 30 to 50% of post-neonatal deaths are due to congenital malformation. Ayurveda , the ancient Indian system of medicine has given due emphasis on the six procreative factors (Shadbhavas) such as Matruja, Pitruja, Aatmaja, Rasaja, Satmyaja and Sattvaja Bhavas. The combinations of these factors give Shreyasi Praja. The physical, mental, social, and spiritual well-being of the person, proper nutrition of the mother during pregnancy and practice of a wholesome regimen, plays a prime role in achieving a healthy offspring, thus structuring a healthy family, society and nation. Negligence to any of these factors will be the main source of unhealthy and defective child birth. The present conceptual study focuses mainly on interpreting Ayurvedic observation on Garbhanga Vikruti with the modern scientific knowledge

Comparison of Compressed Sensing algorithms for MIMO-OFDM Systems

Estimation of the channel accurately in a MIMO-OFDM system is crucial to guarantee the performance of the system. In this paper the Subspace Pursuit (SP), Orthogonal Matching Pursuit (OMP), Compressed Sampling Matching Pursuit(CoSaMP) and Distributed Compressed Sensing(DCS) algorithms combined with Minimum Mean Square Error(MMSE) and Least Mean Square (LMS) tools are used to estimate the channel coefficients for MIMO-OFDM system. These algorithms are used for the channel estimation in MIMO-OFDM system to develop the joint sparsity of the MIMO channel. Simulation results shows that SP, OMP, CoSaMP and DCS algorithms combined with MMSE and LMS tools provides significant reduction in Normalized Mean Square Error (NMSE) when compared to SP ,CoSaMP, DCS algorithms with Least Square (LS) tool and also the conventional channel estimation methods such as LS, MMSE and LMS. Moreover DCS combined with LMS tool performs better than SP and OMP techniques with LMS tool with less computational time complexity

Teratogenic Potential of Garbha Chintamani Rasa in Wistar Albino Rats with focus on physical and behaviour changes

Teratogens are the substances that may produce physical or functional defects in the human embryo or after the pregnant woman exposed to the substance. Exposure to the teratogenic drugs affects the foetus or embryo in a variety of ways, such as the duration of exposure, the amount of teratogenic substance, and the stage of development the embryo or foetus is in during the exposure. Teratogens may affect the embryo or foetus causing physical malformations, problems in the behavioural or emotional development of the child, and decreased intellectual quotient (IQ) in the child. The present study was carried out to assess the teratogenic potential of Garbhachintamani Rasa in Wistar albino rats based on physical and behaviroal abnormalities. The experiment was designed in such a way that the conformed pregnant rats were selected and administered with Garbhachintamani Rasa for 21 consecutive days. The delivered pups were assessed for teratogenicity based on the physical and behavioural parameter in a set of behaviroal tests such as open field test, rota rod and swimming test at different developing periods. The results showed that, there was significant physical and behavioural alteration in the test drug administered at higher dose level as compared to normal control. Thus it can be concluded that the test drug GCR at therapeutic dose showed well tolerated and nearly normal behavioral pattern, whereas at higher dose it can cause behavioral abnormalities in pups

Evaluation of Japakusumadi Yoga for safety profile - Acute Toxicity Profile

Japakusumadi Yoga is an Ayurvedic formulation, indicated for contraception in Ayurveda. This study determines acute toxicity of ‘Japakusumadi Yoga’ an oral formulation in wister albino rats. Single dose acute toxicity was assessed by employing OECD guidelines 425 using AOT software. Test formulations was administered to overnight fasted animals and 14 days observation of dosed (up down as per requirement) rats was done for general appearance, cage side behaviour including increased or decreasing motor activity, convulsions, straub’s reaction, catatonia, muscle spasm, spasticity, ophisthotonus, hyperesthesia, muscle relaxation, anaesthesia, arching and rolling, lacrimation, salivation, diarrhoea, writhing movement, mode of respiration and changes in skin colour etc., with mortality and autopsy finding in case of dead animal. Based on the observation made and recorded it can be concluded that the test drug is without any toxic potential even at the dose of 2000 mg/kg in animals equivalent to 22.4g for human being

Experimental evaluation of Deepana and Pachana Activity of Chitraka Kwatha w.s.r. to different Reduction Criteria

Kashaya Kalpana, also called as Kwatha Kalpana is the third one among the Kashaya Kalpana. It is prepared by boiling the drug in water and reducing it to specific quantity. Different authors have explained different ratio for drug and water and the quantity of reduction also differs according to the purpose used. Acharya Harita and Bhoja have explained Kwatha according to the ratio of reduction and attributed different therapeutic properties according to the ratio of reduction. As per Harita, although the drug and quantity of water used are same for the preparation of Kwatha, if the reduction is different, each reduction will have different therapeutic actions and can be used for different disease conditions. Among the seven types of Kwatha 1/10th reduction and ½ reduction are said to be having Deepana and Pachana action respectively. The Deepana and Pachana action was assesed experimentally in albino rats by adopting some modern parameters. These parameters were logically selected by keeping the modern explaination of digestion and metabolism in mind. When the data obtained by above study is analysed, suggestive of moderate to good effect of Pachana and mild to moderate Deepana action is noted

Pharmaceutico – Analytical Study of Chitraka Kwatha w.s.r. to different reduction criteria

Harita has explained seven types of Kwatha. Among the seven types of Kwatha 1/10th reduction and ½ reduction are said to be having Deepana and Pachana action respectively. The study is planned to study the concept of Deepana and Pachana Kwatha as explained by Harita. For this study, a well known Deepana- Pachana drug i.e. Chitraka is selected and the Kwatha is prepared. In the present study, the Deepana Kwatha (1/10th reduction), Pachana Kwatha(1/2 reduction) are compared with that of the Kwatha prepared by the 3/4th reduction in terms of analytical parameters and the findings were analysed