163 research outputs found

    Higher Education Instructional Change in a U.S. Context: Investigating the Scholarship of Teaching and Learning (SoTL) Innovations at Niagara University

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    A metà Settembre 2013, due degli autori di questo articolo sono stati a Lecce (Italia) realizzando una presentazionein una conferenza sull’istruzione superiore. In quella sede, è stato possibile condividere con i partecipanti i dieci cambiamenti più potenti e significativi che hanno avuto luogo nel vasto panoramadell’accademia americana. L’elenco si componeva di sviluppi di tipo teorico; così come da diversi livelli di implementazione e pratica presso l’Università di Niagara, nell’angolo Nord Est degli Stati Uniti. Tra le iniziative messe in evidenza è stata prima e soprattutto menzionato il lavoro di Ernest Boyer sulla Scholarshipof Teaching and Learning (SoTL), ovvero la sua visione su strade alternative comunque accademiche, basate sulla didattica, per il successo della formazione universitaria. Il percorso tracciato dal movimento SoTL cambia la cultura universitaria, collocando l’insegnamento come priorità; e la “scholarship” (ricerca didattica) emergente dagli studi sull’innovazione didattica come una disciplina di ricerca che può alinearse ad altre nell’ambito accademico. Le esperienze all’Università Niagara forniscono sia un caso di studio dell’implementazione dei suddetti concetti in una moderna istituzione americana; sia un’opportunità per la comparazione con i vari casi delle istituzioni italiane. Inoltre, il lavoro portato avanti dall’università di Niagara risulta competitivo con riguardo ad alcune delle più riconosciute università americane, potendo essere considerato all’avanguardia dell’emergente movimentoSoTL. Questo articolo fornisce un breve resoconto e definizione del modello di Boyer su SoTL, suggerendo come le istituzioni potrebbero adottare tale paradigma sia come strategia per lo sviluppo professionale accademico, sia come adeguata base per la valutazione del lavoro del docente universitario

    Rapid Evolution of Coral Proteins Responsible for Interaction with the Environment

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    Christian R. Voolstra is with King Abdullah University of Science and Technology, Shinichi Sunagawa is with the European Molecular Biology Laboratory, Mikhail V. Matz is with UT Austin, Till Bayer is with King Abdullah University of Science and Technology, Manuel Aranda is with King Abdullah University of Science and Technology, Emmanuel Buschiazzo is with University of California Merced, Michael K. DeSalvo is with University of California San Francisco, Erika Lindquist is with the Department of Energy Joint Genome Institute, Alina M. Szmant is with University of North Carolina Wilmington, Mary Alice Coffroth is with State University of New York at Buffalo, MĂłnica Medina is with University of California Merced.Background -- Corals worldwide are in decline due to climate change effects (e.g., rising seawater temperatures), pollution, and exploitation. The ability of corals to cope with these stressors in the long run depends on the evolvability of the underlying genetic networks and proteins, which remain largely unknown. A genome-wide scan for positively selected genes between related coral species can help to narrow down the search space considerably. Methodology/Principal Findings -- We screened a set of 2,604 putative orthologs from EST-based sequence datasets of the coral species Acropora millepora and Acropora palmata to determine the fraction and identity of proteins that may experience adaptive evolution. 7% of the orthologs show elevated rates of evolution. Taxonomically-restricted (i.e. lineage-specific) genes show a positive selection signature more frequently than genes that are found across many animal phyla. The class of proteins that displayed elevated evolutionary rates was significantly enriched for proteins involved in immunity and defense, reproduction, and sensory perception. We also found elevated rates of evolution in several other functional groups such as management of membrane vesicles, transmembrane transport of ions and organic molecules, cell adhesion, and oxidative stress response. Proteins in these processes might be related to the endosymbiotic relationship corals maintain with dinoflagellates in the genus Symbiodinium. Conclusion/Relevance -- This study provides a birds-eye view of the processes potentially underlying coral adaptation, which will serve as a foundation for future work to elucidate the rates, patterns, and mechanisms of corals' evolutionary response to global climate change.This work was supported by DEB-1054766 to M.V.M. and National Science Foundation grants IOS-0644438 and OCE-0313708 to M.M., and by a Collaborative Travel Fund to C.R.V. made by King Abdullah University of Science and Technology (KAUST). The work conducted by the U.S. Department of Energy Joint Genome Institute is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biological Sciences, School o

    Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

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    SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers
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