76 research outputs found
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Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide
Mesoporous silica nanoparticles MCM – 41 were synthesized with two dimensional hexagonal p6mm symmetry, high specific surface area(~ 980m2/g) narrow pore size and an average particle size of 186 nm. The produced nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM - 41 nanoparticles were analyzed using X–ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco – 2 cells demonstrated negligible cytotoxicity for the MCM–41 nanoparticles
Engineering and manufacturing of pharmaceutical co-crystals : a review on solvent-free manufacturing technologies
Design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offer a tremendous opportunity for the development of new drug products with superior physical and pharmacological properties such as solubility, stability, hydroscopicity, dissolution rates and bioavailability. It is now possible to engineer and develop cocrystals via ‘green chemistry' and environmental friendly approaches such as solid-state synthesis in the absence of organic solvents. In addition, significant efforts are placed on computational screening, cocrystal manufacturing in a continuous manner and real-time monitoring for quality purposes by using various analytical tools. Pharmaceutical cocrystals are not fully exploited yet and there is a lot of ground to cover before they can be successfully utilized as medical products
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Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing
Thermomechanical engineering of pharmaceutical salts in the solid state using continuous extrusion processing (ssTME) is a new novel manufacturing approach. In the present work, we introduce a paradigm for the synthesis of ketoconazole - oxalic acid and ciprofloxacin – maleic acid salts by imparting temperature, shear rate and stress in comparison to liquid assisted grinding (LAG) approach. We demonstrated that thermomechanical synthesis is advantageous by producing high quality and pure, solvent-free pharmaceutical salts by tailoring extrusion processing variables
3D printed microneedles for insulin skin delivery
In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations. Trehalose, mannitol and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also to facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin, with xylitol presenting the best performance. Franz cell release studies were used for in vitro determination of insulin release rates in porcine skin. Insulin was released rapidly within 30 min irrespectively of the microneedle design. 3D printing was proved an effective technology for the fabrication of biocompatible and scalable microneedle patches
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Ultrahigh drug loading and release from biodegradable porous silicon aerocrystals
Biodegradable porous silicon (pSi) is under assessment for the controlled release of both proteins and poorly-soluble API formulations. Super-critical drying of ultrahigh porosity (90%) porous silicon is shown here to preserve much higher mesopore volumes (up to 4mL/g) and surface areas (up to 600m2M/g) than achievable with standardair drying. The payloads and physical state of the model drug (S) (+) ibuprofen, as loaded within a super-critically dried porous silicon carrier matrix,were quantified and assessed using TGA, DSC, cross-sectional EDX, XRD, Raman mapping andFT-IR. In-vitro biodegradability was assessed using Mmolybdenum blue assay and drug release using RPHPLC. Entrapped drug payloads as high as 70%w/w have been achieved, substantially higher than values reported for other mesoporous materials. The entrapped (S) (+) ibuprofen showed faster release than bulk (S) (+) ibuprofen
Evaluation of sesamum gum as an excipient in matrix tablets
In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated
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