2,408 research outputs found
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology.
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview, we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes. We will critically discuss the dual role of proteoglycan-driven inflammation and autophagy in tumor biology, and delineate the potential mechanisms through which soluble extracellular matrix constituents affect the microenvironment associated with inflammatory and neoplastic diseases
TDRSS momentum unload planning
A knowledge-based system is described which monitors TDRSS telemetry for problems in the momentum unload procedure. The system displays TDRSS telemetry and commands in real time via X-windows. The system constructs a momentum unload plan which agrees with the preferences of the attitude control specialists and the momentum growth characteristics of the individual spacecraft. During the execution of the plan, the system monitors the progress of the procedure and watches for unexpected problems
Characterizing the Galactic Gravitational Wave Background with LISA
We present a Monte Carlo simulation for the response of the Laser
Interferometer Space Antenna (LISA) to the galactic gravitational wave
background. The simulated data streams are used to estimate the number and type
of binary systems that will be individually resolved in a 1-year power
spectrum. We find that the background is highly non-Gaussian due to the
presence of individual bright sources, but once these sources are identified
and removed, the remaining signal is Gaussian. We also present a new estimate
of the confusion noise caused by unresolved sources that improves on earlier
estimates.Comment: 32 pages, 14 figures. Version to appear in PR
A parameterized-background data-weak approach to variational data assimilation: formulation, analysis, and application to acoustics
We present a parameterized-background data-weak (PBDW) formulation of the variational data assimilation (state estimation) problem for systems modeled by partial differential equations. The main contributions are a constrained optimization weak framework informed by the notion of experimentally observable spaces; a priori and a posteriori error estimates for the field and associated linear-functional outputs; weak greedy construction of prior (background) spaces associated with an underlying potentially high-dimensional parametric manifold; stability-informed choice of observation functionals and related sensor locations; and finally, output prediction from the optimality saddle in O(M[superscript 3) operations, where M is the number of experimental observations. We present results for a synthetic Helmholtz acoustics model problem to illustrate the elements of the methodology and confirm the numerical properties suggested by the theory. To conclude, we consider a physical raised-box acoustic resonator chamber: we integrate the PBDW methodology and a Robotic Observation Platform to achieve real-time in situ state estimation of the time-harmonic pressure field; we demonstrate the considerable improvement in prediction provided by the integration of a best-knowledge model and experimental observations; we extract, even from these results with real data, the numerical trends indicated by the theoretical convergence and stability analyses.Fondation Sciences Mathematiques de ParisUnited States. Air Force Office of Scientific Research. Multidisciplinary University Research Initiative (Grant FA9550-09-1-0613)United States. Office of Naval Research (Grant N00014-11-1-0713)SUTD-MIT International Design Centr
Chandra Observation of the Cluster Environment of a WAT Radio Source in Abell 1446
Wide-angle tail (WAT) radio sources are often found in the centers of galaxy
clusters where intracluster medium (ICM) ram pressure may bend the lobes into
their characteristic C-shape. We examine the low redshift (z=0.1035) cluster
Abell 1446, host to the WAT radio source 1159+583. The cluster exhibits
possible evidence for a small-scale cluster-subcluster merger as a cause of the
WAT radio source morphology. This evidence includes the presence of temperature
and pressure substructure along the line that bisects the WAT as well as a
possible wake of stripped interstellar material or a disrupted cool core to the
southeast of the host galaxy. A filament to the north may represent cool,
infalling gas that's contributing to the WAT bending while spectroscopically
determined redshifts of member galaxies may indicate some component of a merger
occurring along the line-of-sight. The WAT model of high flow velocity and low
lobe density is examined as another scenario for the bending of 1159+583. It
has been argued that such a model would allow the ram pressure due to the
galaxy's slow motion through the ICM to shape the WAT source. A temperature
profile shows that the cluster is isothermal (kT= 4.0 keV) in a series of
annuli reaching a radius of 400 kpc. There is no evidence of an ongoing cooling
flow. Temperature, abundance, pressure, density, and mass profiles, as well as
two-dimensional maps of temperature and pressure are presented.Comment: 40 AASTeX pages including 15 postscript figures; accepted for
publication in Ap
The second US Naval Observatory CCD Astrograph Catalog (UCAC2)
The second USNO CCD Astrograph Catalog, UCAC2 was released in July 2003.
Positions and proper motions for 48,330,571 sources (mostly stars) are
available on 3 CDs, supplemented with 2MASS photometry for 99.5% of the
sources. The catalog covers the sky area from -90 to +40 degrees declination,
going up to +52 in some areas; this completely supersedes the UCAC1 released in
2001. Current epoch positions are obtained from observations with the USNO
8-inch Twin Astrograph equipped with a 4k CCD camera. The precision of the
positions are 15 to 70 mas, depending on magnitude, with estimated systematic
errors of 10 mas or below. Proper motions are derived by utilizing over 140
ground-and space-based catalogs, including Hipparcos/Tycho, the AC2000.2, as
well as yet unpublished re-measures of the AGK2 plates and scans from the NPM
and SPM plates. Proper motion errors are about 1 to 3 mas/yr for stars to 12th
magnitude, and about 4 to 7 mas/yr for fainter stars to 16th magnitude. The
observational data, astrometric reductions, results, and important information
for the users of this catalog are presented.Comment: accepted by AJ, AAS LaTeX, 14 figures, 10 table
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