Uses and misuses of the STROBE statement: bibliographic study

Objectives Appropriate reporting is central to the application of findings from research to clinical practice. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) recommendations consist of a checklist of 22 items that provide guidance on the reporting of cohort, case-control and cross-sectional studies, in order to facilitate critical appraisal and interpretation of results. STROBE was published in October 2007 in several journals including The Lancet, BMJ, Annals of Internal Medicine and PLoS Medicine. Within the framework of the revision of the STROBE recommendations, the authors examined the context and circumstances in which the STROBE statement was used in the past. Design The authors searched the Web of Science database in August 2010 for articles which cited STROBE and examined a random sample of 100 articles using a standardised, piloted data extraction form. The use of STROBE in observational studies and systematic reviews (including meta-analyses) was classified as appropriate or inappropriate. The use of STROBE to guide the reporting of observational studies was considered appropriate. Inappropriate uses included the use of STROBE as a tool to assess the methodological quality of studies or as a guideline on how to design and conduct studies. Results The authors identified 640 articles that cited STROBE. In the random sample of 100 articles, about half were observational studies (32%) or systematic reviews (19%). Comments, editorials and letters accounted for 15%, methodological articles for 8%, and recommendations and narrative reviews for 26% of articles. Of the 32 observational studies, 26 (81%) made appropriate use of STROBE, and three uses (10%) were considered inappropriate. Among 19 systematic reviews, 10 (53%) used STROBE inappropriately as a tool to assess study quality. Conclusions The STROBE reporting recommendations are frequently used inappropriately in systematic reviews and meta-analyses as an instrument to assess the methodological quality of observational studies

Investigating poisson noise filtering in Digital Breast Tomosynthesis

Digital Breast Tomosynthesis (DBT) is a potential\ud candidate to substitute digital mammography in breast cancer\ud screening. In DBT, projection images are acquired with low\ud levels of radiation, which significantly increases image noise. In\ud this work, we evaluate the effect of a denoising filter, designed for\ud digital mammography, on the reduction of quantum noise in\ud DBT images. This filter is based on an adaptive Wiener filter and\ud the Anscombe transformation, to reduce Poisson noise without\ud significantly affecting image sharpness. Denoising was applied to\ud a set of synthetic DBT images generated using a 3D\ud anthropomorphic software breast phantom. Images without noise\ud was also created to provide ground-truth information. In order to\ud evaluate the denoising performance in different steps of the DBT\ud imaging, filtering was applied separately to the projections\ud (before reconstruction) and to the tomographic slices (after\ud reconstruction). The performance of the filter was evaluated\ud considering qualitative and quantitative analysis of the images\ud before and after denoising.FAPESPCNP

Effect of denoising on the quality of reconstructed images in digital breast tomosynthesis

Individual projection images in Digital Breast Tomosynthesis (DBT) must be acquired with low levels of radiation,\ud which significantly increases image noise. This work investigates the influence of a denoising algorithm and the\ud Anscombe transformation on the reduction of quantum noise in DBT images. The Anscombe transformation is a\ud variance-stabilizing transformation that converts the signal-dependent quantum noise to an approximately signalindependent\ud Gaussian additive noise. Thus, this transformation allows for the use of conventional denoising algorithms,\ud designed for additive Gaussian noise, on the reduction of quantum noise, by working on the image in the Anscombe\ud domain. In this work, denoising was performed by an adaptive Wiener filter, previously developed for 2D\ud mammography, which was applied to a set of synthetic DBT images generated using a 3D anthropomorphic software\ud breast phantom. Ideal images without noise were also generated in order to provide a ground-truth reference. Denoising\ud was applied separately to DBT projections and to the reconstructed slices. The relative improvement in image quality\ud was assessed using objective image quality metrics, such as peak signal-to-noise ratio (PSNR) and mean structural\ud similarity index (SSIM). Results suggest that denoising works better for tomosynthesis when using the Anscombe\ud transformation and when denoising was applied to each projection image before reconstruction; in this case, an average\ud increase of 9.1 dB in PSNR and 58.3% in SSIM measurements was observed. No significant improvement was observed\ud by using the Anscombe transformation when denoising was applied to reconstructed images, suggesting that the\ud reconstruction algorithm modifies the noise properties of the DBT images.FAPESPCNP

Performance of Beef Cattle Fed Diets Containing \u3cem\u3eStylosanthes\u3c/em\u3e and Corn Silages

Reports of the use of tropical legumes in silage production are scarce as these legumes have high contents of crude protein, low water soluble carbohydrate and high buffering capacity, which inhibit the production of silages with good fermentation and nutritional characteristics. Recent research has, however, shown that it is possible to produce good quality silages using tropical legumes (Pereira et al. 2012). Souza et al. (2012) concluded that silage produced from Stylosanthes cv. Campo Grande (Stylosanthes capitata + Stylosanthes macrocephala) at 60% proportion of the dry matter of the diet can replace corn silage in diets for beef cattle in feedlots without altering their intake and productive performance. However, the ideal proportion of this silage in the diets for beef cattle is still unknown. Thus, the objective of this study was to evaluate the intake and performance of beef cattle fed diets with Stylosanthes and corn silages

Inadequate Reporting of Cointerventions, Other Methodological Factors, and Treatment Estimates in Cardiovascular Trials: A Meta-Epidemiological Study.

OBJECTIVE To assess how inadequate reporting of cointerventions influences estimated treatment effects in recent cardiovascular trials. METHODS Medline/Embase were systematically searched from January 1, 2011 to July 1, 2021 for trials evaluating pharmacologic interventions on clinical cardiovascular outcomes published in 5 high-impact journals. Information on adequate vs inadequate reporting of cointerventions, blinding, risk of bias due to deviations of intended interventions (low vs high/some concerns), funding (nonindustry vs industry), design (superiority vs noninferiority), and results were assessed by 2 reviewers. The association with effect sizes was assessed using meta-regression random-effect analysis, expressed as ratios of odds ratios (ROR). RORs of >1.0 indicated that trials with the methodological factor pointing to lower quality report larger treatment estimates. RESULTS In total, 164 trials were included. Of the 164 trials, 124 (74%) did not adequately report cointerventions; 89 of the 164 trials (54%) provided no information regarding cointerventions, and 70 of the 164 (43%) were at risk of bias due to inadequate blinding. Moreover, 86 of the 164 (53%) were at risk of bias due to deviation of intended interventions. Of the 164 trials, 144 (88%) were funded by the industries. Trials with inadequate reporting of cointerventions had larger treatment estimates for the primary end point (ROR, 1.08; 95% CI, 1.01-1.15; I2=0%). No significant association with results for blinding (ROR, 0.97; 95% CI, 0.91-1.03; I2=66%), deviation of intended interventions (ROR, 0.98; 95% CI, 0.92-1.04; I2=0%), or funding (ROR, 1.01; 95% CI, 0.93-1.09; I2=0%) was found. CONCLUSION We conclude that trials with inadequate reporting of cointerventions showed larger treatment effect estimates, potentially indicating overestimation of therapeutic benefit. TRIAL REGISTRATION Prospero Identifier: CRD42017072522

Ricci-flat deformation of orbifolds and localized tachyonic modes

We study Ricci-flat deformations of orbifolds in type II theory. We obtain a simple formula for mass corrections to the twisted modes due to the deformations, and apply it to originally tachyonic and massless states in several examples. In the case of supersymmetric orbifolds, we find that tachyonic states appear when the deformation breaks all the supersymmetries. We also study nonsupersymmetric orbifolds C^2/Z_{2N(2N+1)}, which is T-dual to N type 0 NS5-branes. For N>=2, we compute mass corrections for states, which have string scale tachyonic masses. We find that the corrected masses coincide to ones obtained by solving the wave equation for the tachyon field in the smeared type 0 NS5-brane background geometry. For N=1, we show that the unstable mode representing the bubble creation is the unique tachyonic mode.Comment: 20 pages, minor collection

Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population

In the current model of early Solar System evolution, the stable members of the Jovian and Neptunian Trojan populations were captured into resonance from the leftover reservoir of planetesimals during the outward migration of the giant planets. As a result, both Jovian and Neptunian Trojans share a common origin with the primordial disk population, whose other surviving members constitute today's trans-Neptunian object (TNO) populations. The cold classical TNOs are ultra-red, while the dynamically excited "hot" population of TNOs contains a mixture of ultra-red and blue objects. In contrast, Jovian and Neptunian Trojans are observed to be blue. While the absence of ultra-red Jovian Trojans can be readily explained by the sublimation of volatile material from their surfaces due to the high flux of solar radiation at 5AU, the lack of ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation models. In this work we report the discovery by the Dark Energy Survey (DES) of two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both with inclinations i >30 degrees, making them the highest-inclination known stable Neptunian Trojans. We have measured the colors of these and three other dynamically stable Neptunian Trojans previously observed by DES, and find that 2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such, 2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using a simulation of the DES TNO detection efficiency, we find that there are 162 +/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based on this result, we discuss the possible origin of the ultra-red Neptunian Trojan population and its implications for the formation history of Neptunian Trojans

Adenine interaction with and adsorption on Fe-ZSM-5 zeolites: A prebiotic chemistry study using different techniques

Most adsorption experiments are performed under conditions that did not exist on Earth before the life arose on it. Because adsorption is the first step for all other processes (protection against degradation and polymerization), it is important that it is performed under conditions that existed on prebiotic Earth. In this paper, we use an artificial seawater (seawater 4.0 Ga), which contains major cations and anions that could present on the oceans of the prebiotic Earth. In addition, zeolites, with substituted Fe in the framework, and adenine were probably common substances on the prebiotic Earth. Thus, study the interaction between them is an important issue in prebiotic chemistry. There are two main findings described in this paper. Firstly, zeolites with different Si/Fe ratios adsorbed adenine differently. Secondly, XAFS showed that, after treatments with seawater 4.0 Ga and adenine, an increase in the complexity of the system occurred. In general, salts of seawater 4.0 Ga did not affect the adsorption of adenine onto zeolites and adenine adsorbed less onto zeolites with iron isomorphically substituted. The C=C and NH2 groups of adenine interacted with the zeolites. Gypsum, formed from aqueous species dissolved in seawater 4.0 Ga, precipitated onto zeolites. EPR spectra of zeolites showed lines caused by Fe framework and Fe3+ species. TG curves of zeolites showed events caused by loss of water weakly bound to zeolite (in the 30-140 °C range), water bounded to iron species or cations from seawater 4.0 Ga or located in the cavities of zeolites (157-268 °C) and degradation of adenine adsorbed onto zeolites (360-600 °C). Mass loss follows almost the same order as the amount of adenine adsorbed onto zeolites. The XAFS spectrum showed that Fe3+ could be substituted into the framework of the Fe7-ZSM-5 zeolite