A Buyer\u27s Catalogue of Prepurchase Precautions to Minimize CERCLA Liability in Commercial Real Estate Transactions

Because the cost and incidence of hazardous waste contamination are soaring and because the courts favor broad interpretations of CERCLA\u27s liability provisions, counsel for prospective purchasers of commercial real estate must take certain prepurchase precautions to minimize potential CERCLA liability. This Comment pro- vides practical suggestions as to the aim and form of those precautions. In Part II, this Comment first examines the basic statutory framework and liability scheme of CERCLA. Part III discusses the common law principles of successor liability and their relation to CERCLA\u27s liability mechanism. Finally, in Part IV, this Comment presents a variety of preventive law steps to lessen exposure to hazardous waste liability under CERCLA. Part IV begins by discussing buyers\u27 and sellers\u27 goals when negotiating a real estate purchase and the environmental risks that generally inhere in such a transaction. Part IV then demonstrates in successive subsections how to identify, evaluate, and allocate the risks of a specific purchase. This Comment provides examples of a condition, representations, and an indemnification clause, all of which may serve as protective devices in real estate contracts to allocate these risks. Part IV also considers how courts in four recent cases have responded to buyers\u27 and sellers\u27 attempts to enforce indemnity clauses to avoid CERCLA liability

Spatial and temporal variability in the relative contribution of king mackerel (Scomberomorus cavalla) stocks to winter mixed fisheries off South Florida

King mackerel (Scomberomorus cavalla) are ecologically and economically important scombrids that inhabit U.S. waters of the Gulf of Mexico (GOM) and Atlantic Ocean (Atlantic). Separate migratory groups, or stocks, migrate from eastern GOM and southeastern U.S. Atlantic to south Florida waters where the stocks mix during winter. Currently, all winter landings from a management-defined south Florida mixing zone are attributed to the GOM stock. In this study, the stock composition of winter landings across three south Florida sampling zones was estimated by using stock-specific otolith morphological variables and Fourier harmonics. The mean accuracies of the jackknifed classifications from stepwise linear discriminant function analysis of otolith shape variables ranged from 66−76% for sex-specific models. Estimates of the contribution of the Atlantic stock to winter landings, derived from maximum likelihood stock mixing models, indicated the contribution was highest off southeastern Florida (as high as 82.8% for females in winter 2001−02) and lowest off southwestern Florida (as low as 14.5% for females in winter 2002−03). Overall, results provided evidence that the Atlantic stock contributes a certain, and perhaps a significant (i.e., ≥50%), percentage of landings taken in the management-defined winter mixing zone off south Florida, and the practice of assigning all winter mixing zone landings to the GOM stock shoul

A New Bispectral Test for Nonlinear Serial Dependence

Bispectrum, nonlinearity, time series analysis

Endothelial Glycocalyx Degradation in Critical Illness and Injury

The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is composed of glycosaminoglycans and the proteins that tether them to the plasma membrane. Interest in its properties and function has grown, particularly in the last decade, as its importance to endothelial barrier function has come to light. Endothelial glycocalyx studies have revealed that many critical illnesses result in its degradation or removal, contributing to endothelial dysfunction and barrier break-down. Loss of the endothelial glycocalyx facilitates the direct access of immune cells and deleterious agents (e.g., proteases and reactive oxygen species) to the endothelium, that can then further endothelial cell injury and dysfunction leading to complications such as edema, and thrombosis. Here, we briefly describe the endothelial glycocalyx and the primary components thought to be directly responsible for its degradation. We review recent literature relevant to glycocalyx damage in several critical illnesses (sepsis, COVID-19, trauma and diabetes) that share inflammation as a common denominator with actions by several common agents (hyaluronidases, proteases, reactive oxygen species, etc.). Finally, we briefly cover strategies and therapies that show promise in protecting or helping to rebuild the endothelial glycocalyx such as steroids, protease inhibitors, anticoagulants and resuscitation strategies

Case Report: Inflammation and Endothelial Injury Profiling of COVID-19 Pediatric Multisystem Inflammatory Syndrome (MIS-C)

Introduction: COVID-19 is associated with a novel multi-system inflammatory syndrome that shares some characteristics with Kawasaki\u27s Disease. The syndrome manifestation is delayed relative to COVID-19 onset, with a spectrum of clinical severity. Clinical signs may include persistent fever, gastrointestinal symptoms, cardiac inflammation and/or shock. Case Presentation: We measured 59 inflammatory and endothelial injury plasma analytes in an adolescent girl that presented with malaise, fever, cough, strawberry tongue and jaundice. Her COVID-19 status was positive with detection of 2 SARS-CoV-2 viral genes using polymerase chain reaction. She was treated with intravenous immunoglobulin prior to blood draw, but our plasma measurements suggested a unique analyte expression pattern associated with inflammation, endothelial injury and microvascular glycocalyx degradation. Conclusions: COVID-19 is associated with a multi-system inflammatory syndrome and a unique inflammatory and endothelial injury signature. Summary: Analyte markers of inflammation and endothelial cell injury might serve as putative biomarkers and/or be investigated further as potential therapeutic targets

Pulmonary Capillary Hemorrhage Induced by Acoustic Radiation Force Impulse Shear Wave Elastography in Ventilated Rats

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151830/1/jum14950.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151830/2/jum14950_am.pd

Boundary Conformal Field Theories, Limit Sets of Kleinian Groups and Holography

In this paper,based on the available mathematical works on geometry and topology of hyperbolic manifolds and discrete groups, some results of Freedman et al (hep-th/9804058) are reproduced and broadly generalized. Among many new results the possibility of extension of work of Belavin, Polyakov and Zamolodchikov to higher dimensions is investigated. Known in physical literature objections against such extension are removed and the possibility of an extension is convincingly demonstrated.Comment: 62 pages, 5 figure