Microgravity cursor control device evaluation for Space Station Freedom workstations

This research addressed direct manipulation interface (curser-controlled device) usability in microgravity. The data discussed are from KC-135 flights. This included pointing and dragging movements over a variety of angles and distances. Detailed error and completion time data provided researchers with information regarding cursor control shape, selection button arrangement, sensitivity, selection modes, and considerations for future research

Death : a Christian perspective

"It was by no means conceived that this one writing could answer all the questions concerning the Christian answers or beliefs in regard to death. The theme presented here is an historical survey of representative periods and figures from the ancient Hebrew times through the Protestant Reformation which demonstrates the evolving and emerging patterns of death. No Christian perspective could be found without dealing with the fundamental concepts herein. As the title suggests, this is simply a start but nevertheless a basic start. All of Christian theology is related to the Death of Christ so it is to His Death that the Church must continually readdress itself.” – from the Introduction

The novel missense mutation Met48Lys in FKBP22 changes its structure and functions.

Mutations in the FKBP14 gene encoding FKBP22 (FK506 Binding Protein 22 kDa) cause kyphoscoliotic Ehlers-Danlos Syndrome (kEDS). The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA leads to a wide spectrum of clinical phenotypes including progressive kyphoscoliosis, joint hypermobility, hypotonia, hyperelastic skin, hearing loss and aortic rupture. Our previous work showed that these phenotypic features could be correlated with the functions of FKBP22, which preferentially binds to type III, VI and X collagens, but not to type I, II or V collagens. We also showed that FKBP22 catalyzed the folding of type III collagen through its prolyl isomerase activity and acted as a molecular chaperone for type III collagen. Recently, a novel missense mutation Met48Lys in FKBP22 was identified in a patient with kEDS. In this report, we expand the list of substrates of FKBP22 and also demonstrate that the Met48Lys mutation diminishes the activities of FKBP22, indicating that pathology can arise from absence of FKBP22, or partial loss of its function

Adaptation du recrutement et de la fidélisation des patients volontaires pour l’enseignement des habiletés cliniques pendant la COVID-19

Implication Statement Institutions have been faced with the unique challenge of continuing to deliver medical education to students in a COVID-19 environment.1,2 Clinical skills teaching must be adapted to the pandemic environment, which begins with retaining Volunteer Patient (VP) engagement to facilitate the development of students’ patient care aptitudes. The number of available VPs has been significantly reduced by the pandemic. We propose actionable solutions to recruit, engage, and retain VPs that can be easily adopted at any site. The SLIM-COVID framework can assist programs in altering curricula to deliver clinical skills with patient involvement in a pandemic environment.Énoncé des implications de la recherche Les établissements d’éducation médicale ont été confrontés au défi unique de continuer à assurer leurs services aux étudiants dans un environnement COVID-19.1,2 L'enseignement des habiletés cliniques doit être adapté au contexte de la pandémie, en premier lieu par le maintien de la participation des patients volontaires (PV) afin de faciliter le développement des aptitudes requises pour les soins aux patients. Le nombre de PV disponibles a considérablement baissé en raison de la pandémie. Nous proposons des solutions concrètes pour recruter, motiver et retenir les PV, ces solutions pouvant être facilement introduites dans tous les types de site. Le cadre SLIM-COVID peut faciliter l’adaptation des programmes d'études pour assurer la participation de patients dans l'enseignement des habiletés cliniques dans le contexte de la pandémie

The Deformable Mirror Demonstration Mission (DeMi) CubeSat: optomechanical design validation and laboratory calibration

Coronagraphs on future space telescopes will require precise wavefront correction to detect Earth-like exoplanets near their host stars. High-actuator count microelectromechanical system (MEMS) deformable mirrors provide wavefront control with low size, weight, and power. The Deformable Mirror Demonstration Mission (DeMi) payload will demonstrate a 140 actuator MEMS deformable mirror (DM) with \SI{5.5}{\micro\meter} maximum stroke. We present the flight optomechanical design, lab tests of the flight wavefront sensor and wavefront reconstructor, and simulations of closed-loop control of wavefront aberrations. We also present the compact flight DM controller, capable of driving up to 192 actuator channels at 0-250V with 14-bit resolution. Two embedded Raspberry Pi 3 compute modules are used for task management and wavefront reconstruction. The spacecraft is a 6U CubeSat (30 cm x 20 cm x 10 cm) and launch is planned for 2019.Comment: 15 pages, 10 figues. Presented at SPIE Astronomical Telescopes + Instrumentation, Austin, Texas, US

Calibration and Testing of the Deformable Mirror Demonstration Mission (DeMi) CubeSat Payload

The Deformable Mirror Demonstration Mission (DeMi) is a 6U CubeSat that will operate and characterize the on-orbit performance of a Microelectromechanical Systems (MEMS) deformable mirror (DM) with both an image plane and a Shack-Hartmann wavefront sensor (SHWFS). Coronagraphs on future space telescopes will require precise wavefront control to detect and characterize Earth-like exoplanets. High-actuator count MEMS deformable mirrors can provide wavefront control with low size, weight, and power. The DeMi payload will characterize the on-orbit performance of a 140 actuator MEMS DM with 5.5 _m maximum stroke, with a goal of measuring individual actuator wavefront displacement contributions to a precision of 12 nm. The payload will be able to measure low order aberrations to l/10 accuracy and l/50 precision, and will correct static and dynamic wavefront phase errors to less than 100 nm RMS. The DeMi team developed miniaturized DM driver boards to fit within the CubeSat form factor, and two cross-strapped Raspberry Pi 3 boards are used as payload computers. We present an overview of the payload design, the assembly, integration and test progress, and the miniaturized DM driver characterization process. Launch is planned for late 2019