Adaptability to plus lens therapy

Adaptability to plus lens therap

Telepresence for space: The state of the concept

The purpose here is to examine the concept of telepresence critically. To accomplish this goal, first, the assumptions that underlie telepresence and its applications are examined, and second, the issues raised by that examination are discussed. Also, these assumptions and issues are used as a means of shifting the focus in telepresence from development to user-based research. The most basic assumption of telepresence is that the information being provided to the human must be displayed in a natural fashion, i.e., the information should be displayed to the same human sensory modalities, and in the same fashion, as if the person where actually at the remote site. A further fundamental assumption for the functional use of telepresence is that a sense of being present in the work environment will produce superior performance. In other words, that sense of being there would allow the human operator of a distant machine to take greater advantage of his or her considerable perceptual, cognitive, and motor capabilities in the performance of a task than would more limited task-related feedback. Finally, a third fundamental assumption of functional telepresence is that the distant machine under the operator's control must substantially resemble a human in dexterity

Microbiome composition within a sympatric species complex of intertidal isopods (Jaera albifrons)

Data Availability: Raw sequence data alongside all relevant metadata are deposited in the NCBI short-read archive (SRA) at accession SRP132549. Funding: This work was funded by the UK Natural Environment Research Council (NERC), grant NE/M015661/1, awarded to SBP and AD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments: We are grateful to Heather Ritchie and Laura Howell for fieldwork assistance. We acknowledge the computational support of the Maxwell HPC cluster funded by the University of Aberdeen.Peer reviewedPublisher PD

Along-Strike Growth of the Ostler Fault, New Zealand: Consequences for Drainage Deflection above Active Thrust

Rarely are geologic records available to constrain the spatial and temporal evolution of thrust‐fault growth as slip accumulates during repeated earthquake events. Here, we utilize multiple generations of dated and deformed fluvial terraces to explore two key aspects of the along‐strike kinematic development of the Ostler fault zone in southern New Zealand over the past ∼100 k.y.: accumulation of fault slip through space and time and fixed‐length thrust growth that results in patterns of drainage diversion suggestive of laterally propagating faults. Along the Ostler fault, surface deformation patterns revealed by topographic surveying of terrace profiles in nine transverse drainages define systematic variations in fault geometry and suggest deformation over both listric and planar thrust ramps. Kinematic modeling of folded terrace profiles and \u3e100 fault‐scarp surveys along major fault sections reveals remarkably similar slip distributions for multiple successions of geomorphic surfaces spanning ∼100 k.y. Spatially abrupt and temporally sustained displacement gradients across zones of fault section overlap suggest that either persistent barriers to fault propagation or interference between overlapping faults dominate the interactions of fault tips from the scale of individual scarps to the entire fault zone. Deformed terrace surfaces dated using optically stimulated luminescence and cosmogenic radionuclides indicate steady, maximum rates of fault slip of ∼1.9 mm/yr during the Late Quaternary. Slip data synthesized along the central Ostler fault zone imply that displacement accumulated at approximately constant fault lengths over the past ∼100 k.y. A northward temporal progression of abandoned wind gaps along this section thus reflects lateral tilting in response to amplification of displacement, rather than simple fault lengthening or lateral propagation. Oscillations of climate at ∼104‐yr time scales modulate the formation and incision of geomorphic surfaces during successive glacial stages. Superimposed on apparently steadier rates of fault slip, such climate‐dependent surfaces contribute to a pattern of progressive drainage deflection along the central Ostler fault zone that is largely independent of fault propagation

Genome-wide association and genome partitioning reveal novel genomic regions underlying variation in gastrointestinal nematode burden in a wild bird

Acknowledgements This study was funded by a BBSRC studentship (MA Wenzel) and NERC grants NE/H00775X/1 and NE/D000602/1 (SB Piertney). The authors are grateful to Fiona Leckie, Andrew MacColl, Jesús Martínez-Padilla, François Mougeot, Steve Redpath, Pablo Vergara† and Lucy M.I. Webster for samples; Keliya Bai, Daisy Brickhill, Edward Graham, Alyson Little, Daniel Mifsud, Lizzie Molyneux and Mario Röder for fieldwork assistance; Gillian Murray-Dickson and Laura Watt for laboratory assistance; Heather Ritchie for helpful comments on manuscript drafts; and all estate owners, factors and keepers for access to field sites, most particularly Stuart Young and Derek Calder (Edinglassie), Simon Blackett, Jim Davidson and Liam Donald (Invercauld and Glas Choille), Richard Cooke and Fred Taylor† (Invermark) and T. Helps (Catterick).Peer reviewedPostprin

Human monoclonal antibodies to Plasmodium falciparum circumsporozoite protein for transient passive protection of malaria travelers to endemic areas

Plasmodium falciparum, is a protozoa that causes over 214 million cases of Malaria worldwide and the World Health Organization reported an estimated 438,000 deaths attributed to malaria in 2015. Current prevention strategies have reduced malaria cases but they are either costly, have poor efficacy or resistance has begun to develop. There is a global need for an effective pre-exposure prophylaxis treatment. The leading Malaria vaccine candidate is RTS,S which contains a monovalent Plasmodium falciparum circumsporozoite protein (CSP). The goal of this vaccine is to induce anti-CSP antibodies that would block sporozoite invasion of hepatocytes and thereby hinder parasite development into a blood-stage infection that causes malaria morbidity and mortality. Antibodies isolated from individuals who have received the RTS,S vaccine have been shown to prevent infection of hepatocytes, suggesting that CSP antibodies could be used prophylactically. However, phase III trial results of the vaccine have shown underwhelming efficacy in children. Growing resistance to transient protection strategies for travelers and low efficacy in vaccine trials suggest there is a need for a new treatment strategy. The generation of CSP specific human monoclonal antibodies (mAbs) would be useful as prevention especially for individuals that are temporarily exposed to Malaria in endemic regions such as travelers or military personnel. Isolation and production of therapeutic mAbs traditionally utilizes a handful of techniques including antibody engineering, phage display or hybridoma generation from transgenic mice. We have sorted antigen-specific memory B-cells from the peripheral blood of children naturally infected with malaria to isolate CSP-specific memory B-cells. These cells were individually sorted and PCR was performed to amplify antibody variable regions of the B-cell’s antibody mRNA. Samples that produced heavy and light chain antibody sequence were cloned and transiently expressed. We plan to characterize these mAbs for binding and neutralization of CSP to identify functional therapeutic mAbs

Geomorphic Constraints on Listric Thrust Faulting: Implications for Active Deformation in the Mackenzie Basin, South Island, New Zealand

Deformed fluvial terraces preserved over active thrust-related folds record the kinematics of folding as fault slip accumulates on the underlying thrust. In the Mackenzie Basin of southern New Zealand, the kinematics revealed by folded fluvial terraces along the active Ostler and Irishman Creek fault zones are inconsistent with traditional models for thrust-related folding in which spatially uniform rock uplift typically occurs over planar fault ramps. Instead, warped and tilted terraces in the Mackenzie are characterized by broad, continuous backlimbs and abrupt forelimbs and suggest folding through progressive limb rotation. By relating this pattern of surface deformation to the underlying thrust with a newly developed, simple geometric and kinematic model, we interpret both faults as listric thrusts rooted at depth into gently dipping planar fault ramps. Constraints on the model from detailed topographic surveying of deformed terraces, ground-penetrating radar over active fault scarps, and luminescence dating of terrace surfaces suggest slip rates for the Ostler and Irishman Creek faults of ~1.1– 1.7 mm/yr and~0.5–0.7 mm/yr, respectively. The predicted depth of listric faulting for the Ostler fault (0.70 +0.1-0.2 km) and the Irishman Creek fault (1.3+0.1-0.5 km) generally agrees with geophysical estimates of basin depth in the Mackenzie and suggests control of preexisting basin architecture on the geometry of active thrusting. Despite the potential effects of changes in fault curvature and hanging wall internal deformation, the methodology presented here provides a simple tool for approximating the kinematics of surface deformation associated with slip along listric, or curviplanar, thrust faults

The role of parasite-driven selection in shaping landscape genomic structure in red grouse (Lagopus lagopus scotica)

Acknowledgements This study was funded by a BBSRC studentship (MAW) and NERC grants NE/H00775X/1 and NE/D000602/1 (SBP). The authors are grateful to Mario Röder and Keliya Bai for fieldwork assistance, and all estate owners, factors and keepers for access to field sites, most particularly MJ Taylor and Mike Nisbet (Airlie), Neil Brown (Allargue), RR Gledson and David Scrimgeour (Delnadamph), Andrew Salvesen and John Hay (Dinnet), Stuart Young and Derek Calder (Edinglassie), Kirsty Donald and David Busfield (Glen Dye), Neil Hogbin and Ab Taylor (Glen Muick), Alistair Mitchell (Glenlivet), Simon Blackett, Jim Davidson and Liam Donald (Invercauld), Richard Cooke and Fred Taylor† (Invermark), Shaila Rao and Christopher Murphy (Mar Lodge), and Ralph Peters and Philip Astor (Tillypronie). S.B.P. and S.M.R. conceived and designed the study. M.A.W. performed field and laboratory work. A.D. and M.C.J. developed SNP markers. M.A.W. analysed the data. M.A.W. and S.B.P. wrote the manuscript.Peer reviewedPostprin