A study of a plume induced separation shock wave, including effects of periodic plume unsteadiness

A wind tunnel investigation was conducted to study the flow field in which separation is caused by an expanding plume, with emphasis on effects associated with periodic unsteadiness in the plume. The separation shock was photographed with high speed motion pictures, from which mean shock position and excursion data were reported. Pressure fluctuations were measured beneath the separation shock. A response of the separation shock to plume periodic unsteadiness was identified, and the magnitude of a corresponding transfer function was defined. Small harmonic effects in plume response to periodic unsteadiness were noted. The stabilizing effect of a lateral surface protuberance near the separation shock wave was investigated. The protuberance configuration was a lateral circular cylinder, and various diameters, all less than the boundary layer thickness, were employed

Effects of periodic unsteadiness of a rocket engine plume on the plume-induced separation shock wave

A wind tunnel investigation was conducted to study the flow field in which separation is caused by an expanding plume, with emphasis on effects associated with periodic unsteadiness in the plume. The separation shock was photographed with high speed motion pictures, from which mean shock position and excursion data are reported. Pressure fluctuations were measured beneath the separation shock and statistics of the results are reported. A response of the separation shock to plume periodic unsteadiness was identified, and the magnitude of a corresponding transfer function was defined and is reported

Efficient injection from large telescopes into single-mode fibres: Enabling the era of ultra-precision astronomy

Photonic technologies offer numerous advantages for astronomical instruments such as spectrographs and interferometers owing to their small footprints and diverse range of functionalities. Operating at the diffraction-limit, it is notoriously difficult to efficiently couple such devices directly with large telescopes. We demonstrate that with careful control of both the non-ideal pupil geometry of a telescope and residual wavefront errors, efficient coupling with single-mode devices can indeed be realised. A fibre injection was built within the Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument. Light was coupled into a single-mode fibre operating in the near-IR (J-H bands) which was downstream of the extreme adaptive optics system and the pupil apodising optics. A coupling efficiency of 86% of the theoretical maximum limit was achieved at 1550 nm for a diffraction-limited beam in the laboratory, and was linearly correlated with Strehl ratio. The coupling efficiency was constant to within <30% in the range 1250-1600 nm. Preliminary on-sky data with a Strehl ratio of 60% in the H-band produced a coupling efficiency into a single-mode fibre of ~50%, consistent with expectations. The coupling was >40% for 84% of the time and >50% for 41% of the time. The laboratory results allow us to forecast that extreme adaptive optics levels of correction (Strehl ratio >90% in H-band) would allow coupling of >67% (of the order of coupling to multimode fibres currently). For Strehl ratios <20%, few-port photonic lanterns become a superior choice but the signal-to-noise must be considered. These results illustrate a clear path to efficient on-sky coupling into a single-mode fibre, which could be used to realise modal-noise-free radial velocity machines, very-long-baseline optical/near-IR interferometers and/or simply exploit photonic technologies in future instrument design.Comment: 15 pages, 16 figures, 1 table, published in A&

A novel high-content phenotypic screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes

Kinetoplastid parasites cause diverse neglected diseases in humans and livestock, with an urgent need for new treatments. The survival of kinetoplastids depends on their uniquely structured mitochondrial genome (kDNA), the eponymous kinetoplast. Here, we report the development of a high-content screen for pharmacologically induced kDNA loss, based on specific staining of parasites and automated image analysis. As proof of concept, we screened a diverse set of ∼14,000 small molecules and exemplify a validated hit as a novel kDNA-targeting compound

Experimental Characterization of Space Charge in IZIP Detectors

Interleaved ionization electrode geometries offer the possibility of efficient rejection of near-surface events. The CDMS collaboration has implemented this interleaved approach for the charge and phonon readout for our germanium detectors. During a recent engineering run with negligible ambient radiation, the detectors were found to lose ionization stability more quickly than expected. This paper summarizes studies done in order to determine the underlying cause of the instability, as well as possible running modes that maintain stability without unacceptable loss of livetime. Additionally, first results are shown for the new version IZIP mask which attempts to improve the overall stability of the detectors.United States. Dept. of Energy (Grant DE-AC02-76SF00515)National Science Foundation (U.S.) (Awards 0705052, 0902182, 1004714, and 0802575

Aquifer thermal energy storage: An attempt to counter free thermal convection

This is the published version. Copyright 1983 American Geophysical UnionIn previous Aquifer Thermal Energy Storage (ATES) experiments, appreciable free thermal convection was observed. In an attempt to counter the detrimental effects of convection, a dual recovery well system was constructed at the Mobile site and a third injection-storage-recovery cycle performed. Using a partially penetrating well, cycle 3-3 injection began on April 7, 1982. A total of 56,680 m3 of 79°C water were injected. After 57 days of storage, production began with a dual recovery well system. Due to the dominating effect of nonhomogeneities, the dual well system did not work particularly well, and a recovery factor of 0.42 was achieved. The degree of aquifer heterogeneity at the location of the present experiments was not apparent during previous experiments at a location only 109 m away, although pumping tests indicated similar values of transmissivity. Therefore aquifers with the same transmissivity can behave quite differently in a thermal sense. Heat conduction to the upper aquitard was a major energy loss mechanism. Water sample analyses indicated that there were no important changes in the chemical constituents during the third set of experiments. There was a 19% increase in total dissolved solids. At the end of injection, the land surface near the injection well had risen 1.39 cm with respect to bench marks located 70 m away

The Subaru Coronagraphic Extreme Adaptive Optics system: enabling high-contrast imaging on solar-system scales

The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is a multipurpose high-contrast imaging platform designed for the discovery and detailed characterization of exoplanetary systems and serves as a testbed for high-contrast imaging technologies for ELTs. It is a multi-band instrument which makes use of light from 600 to 2500nm allowing for coronagraphic direct exoplanet imaging of the inner 3 lambda/D from the stellar host. Wavefront sensing and control are key to the operation of SCExAO. A partial correction of low-order modes is provided by Subaru's facility adaptive optics system with the final correction, including high-order modes, implemented downstream by a combination of a visible pyramid wavefront sensor and a 2000-element deformable mirror. The well corrected NIR (y-K bands) wavefronts can then be injected into any of the available coronagraphs, including but not limited to the phase induced amplitude apodization and the vector vortex coronagraphs, both of which offer an inner working angle as low as 1 lambda/D. Non-common path, low-order aberrations are sensed with a coronagraphic low-order wavefront sensor in the infrared (IR). Low noise, high frame rate, NIR detectors allow for active speckle nulling and coherent differential imaging, while the HAWAII 2RG detector in the HiCIAO imager and/or the CHARIS integral field spectrograph (from mid 2016) can take deeper exposures and/or perform angular, spectral and polarimetric differential imaging. Science in the visible is provided by two interferometric modules: VAMPIRES and FIRST, which enable sub-diffraction limited imaging in the visible region with polarimetric and spectroscopic capabilities respectively. We describe the instrument in detail and present preliminary results both on-sky and in the laboratory.Comment: Accepted for publication, 20 pages, 10 figure

Poor survival outcomes in HER2 positive breast cancer patients with low grade, node negative tumours

We present a retrospective analysis on a cohort of low-grade, node-negative patients showing that human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in this otherwise very good prognostic group. Our results provide support for the use of adjuvant trastuzumab in patients who are typically classified as having very good prognosis, not routinely offered standard chemotherapy, and who as such do not fit current UK prescribing guidelines for trastuzumab

The Grizzly, February 26, 1988

Art Expo • Patterns Campaign Nears Completion • Is He a Dummy or Isn\u27t He? • Patterns Campaign Nears Completion • Editorial: Boo! Hiss! to Prof. Epistle • Letter: Doughty to Grizzly Editor - Kiss Off; Get a Room; Cookbooks Stew Students • Zimmers Open Hearts • Curious George to the Rescue • Teams Sport Banner Seasons • Lady Bears Net Successful Record • Wrestlers Reaching Peak • The Grizzly Proudly Salutes Our Bear Pack Champions • Bears Making Tracks • Harrison Floating on Cloud Nine • Ensemble Enchanting • Projected Art Center Plans • Air Band Acts Wow Wismer Crowdhttps://digitalcommons.ursinus.edu/grizzlynews/1206/thumbnail.jp