Interdependent, imagined, and embodied mobilities in mobile social space:Disruptions in ‘normality’, ‘habit’ and ‘routine’

This article draws on ethnographic research of everyday mobilities to further understanding of interdependent mobilities practices in relation to normality, habit and routine. The contention here is that a rethinking of ‘normality’, ‘habit’ and ‘routine’ reveals how mobilities are interdependent, imagined and embodied. We draw from Lefebvre's (1991) notions of social space and rhythmanalysis to illustrate the relationality of these aspects of mobility. In doing so, we build on recent theorisations of habit in the field of mobilities, which have opened this concept as a key site for interrogating body–society relationships arguing that both ‘routine’ and ‘normality’ have similar potential in revealing the regulation and control of everyday spaces. We consider everyday embodied engagements with mobile space and how these become normalised, habitualised and routinised. This paper draws from a Research Council UK Energy Programme funded project, ‘Disruption, the raw material for carbon change’, which uses ‘disruption’ as a lens through which to reveal potential for changes in mobility practices that result in carbon reduction. Our exploration of interdependent, imagined and embodied mobilities concurs with existing scholarship in the mobilities field that argues for a rethinking of individualised conceptions of ‘normality’, ‘habit’ and ‘routine’ in seeking an understanding of mobilities that are socially, culturally and materially contingent.</p

Understanding everyday mobilities through the lens of disruption

Our research has aimed to elaborate on the ways in which movement, and the lack of it or its disruption, is socially, culturally and materially contingent. In this chapter, moments when mobilities become ‘disrupted’ in some way offer a lens through which socio-spatial interdependencies and mobile injustices are revealed. Our ethnographic data clearly illustrates that disruptions to mobilities are more often than not triggered by events outside of the transport system. Thus, we argue that we need to move beyond transport in understanding the intricacies of relational mobilities, and how they are negotiated and maintained at the micro level

Acute Renal Replacement Therapy in Pediatrics

Acute kidney injury (AKI) independently increases morbidity and mortality in children admitted to the hospital. Renal replacement therapy (RRT) is an essential therapy in the setting of AKI and fluid overload. The decision to initiate RRT is complex and often complicated by concerns related to patient hemodynamic and thermodynamic instability. The choice of which RRT modality to use depends on numerous criteria that are both patient and treatment center specific. Surprisingly, despite decades of use, no randomized, controlled trial study involving RRT in pediatrics has been performed. Because of these factors, clear-cut consensus is lacking regarding key questions surrounding RRT delivery. In this paper, we will summarize existing data concerning RRT use in children. We discuss the major modalities and the data-driven specifics of each, followed by controversies in RRT. As no standard of care is in widespread use for RRT in AKI or in multiorgan disease, we conclude in this paper that prospective studies of RRT are needed to identify best practice guidelines

Discourses of Mobility: Institutions, Everyday Lives and Embodiment

This article seeks to contribute to the growing body of literature on the politics of mobility, revealing the ways in which the governing of mobility intersects with everyday mobile lives. We suggest that dominant and enduring institutional discourses of mobility, which are pervaded by a privileging of individualised automobility, can be conceptualised around a framework of morality, modernity and freedom. By examining everyday discourses of mobility in this context we highlight the ways in which these discourses reflect and resist normative sets of knowledge and practices. It is argued that by emphasising the everyday and mundane in an analysis of discourses of mobility, and acknowledging their situatedness in prevailing normative discourses, we are then able to focus on how movement is a social and cultural practice in constant negotiation and (re)production

Immunology and infectious disease/ Edit. : Lesley A. Doughty

x, 276 hal. : ill.; 21 cm

Immunology and infectious disease/ Edit. : Lesley A. Doughty

x, 276 hal. : ill.; 21 cm

In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

Although studies have shown increased evidence of death receptor-driven apoptosis in intestinal lymphoid cells, splenocytes, and the liver following the onset of polymicrobial sepsis, little is known about the mediators controlling this process or their pathologic contribution. We therefore attempted to test the hypothesis that the hydrodynamic administration of small interfering RNA (siRNA) against the death receptor, Fas or caspase-8, should attenuate the onset of morbidity and mortality seen in sepsis, as produced by cecal ligation and puncture (CLP). We initially show that in vivo administration of green fluorescent protein (GFP) siRNA in GFP transgenic mice results in a decrease in GFP fluorescence in most tissues. Subsequently, we also found that treating septic nontransgenic mice with siRNA targeting Fas or caspase-8 but not GFP (used as a control here) decreased the mRNA, in a sustained fashion up to 10 days, and protein expression of Fas and caspase-8, respectively. In addition, transferase-mediated dUTP (deoxyuridine triphosphate) nick end labeling (TUNEL) and active caspase-3 analyses revealed a decrease in apoptosis in the liver and spleen but not the thymus following siRNA treatment. Indices of liver damage were also decreased. Finally, the injection of Fas or caspase-8 given not only 30 minutes but up to 12 hours after CLP significantly improved the survival of septic mice