Unstable fields in Kerr spacetimes

We show that both the interior region $r<M-\sqrt{M^2-a^2}$ of a Kerr black hole and the $a^2>M^2$ Kerr naked singularity admit unstable solutions of the Teukolsky equation for any value of the spin weight. For every harmonic number there is at least one axially symmetric mode that grows exponentially in time and decays properly in the radial directions. These can be used as Debye potentials to generate solutions for the scalar, Weyl spinor, Maxwell and linearized gravity field equations on these backgrounds, satisfying appropriate spatial boundary conditions and growing exponentially in time, as shown in detail for the Maxwell case. It is suggested that the existence of the unstable modes is related to the so called "time machine" region, where the axial Killing vector field is time-like, and the Teukolsky equation, restricted to axially symmetric fields, changes its character from hyperbolic to elliptic

Axonal and dendritic endocytic pathways in cultured neurons

The endocytic pathways from the axonal and dendritic surfaces of cultured polarized hippocampal neurons were examined. The dendrites and cell body contained extensive networks of tubular early endosomes which received endocytosed markers from the somatodendritic domain. In axons early endosomes were confined to presynaptic terminals and to varicosities. The somatodendritic but not the presynaptic early endosomes were labeled by internalized transferrin. In contrast to early endosomes, late endosomes and lysosomes were shown to be predominantly located in the cell body. Video microscopy was used to follow the transport-t of internalized markers from the periphery of axons and dendrites back to the cell body. Labeled structures in both domains moved unidirectionally by retrograde fast transport. Axonally transported organelles were sectioned for EM after video microscopic observation and shown to be large multivesicular body-like structures. Similar structures accumulated at the distal side of an axonal lesion. Multivesicular bodies therefore appear to be the major structures mediating transport of endocytosed markers between the nerve terminals and the cell body. Late endocytic structures were also shown to be highly mobile and were observed moving within the cell body and proximal dendritic segments. The results show that the organization of the endosomes differs in the axons and dendrites of cultured rat hippocampal neurons and that the different compartments or stages of the endocytic pathways can be resolved spatially

Nocodazole-Dependent Transport, and Brefeldin A-Sensitive Processing and Sorting, of Newly Synthesized Membrane-Proteins in Cultured Neurons

The envelope glycoproteins of Semliki Forest virus (SFV), Vesicular Stomatitis virus (VSV), and Influenza Fowl Plague virus (FPV) are vectorially targeted in neurons to the plasma membrane of dendrites (SFV and VSV) and axons (FPV), To gain insight into the mechanisms responsible for such polarized delivery we have examined the effects on neurons of nocodazole and brefeldin A (BFA), which are known to cause microtubule depolymerization and disassembly of the Golgi apparatus, respectively, Nocodazole treatment blocked transport of all viral glycoproteins to both axons and dendrites, BFA treatment induced disruption of the Golgi complex, including the trans-Golgi network (TGN), and tubulation of endosomes, However, the delivery of the SFV and FPV glycoproteins to the cell surface was not affected significantly by BFA, although processing and sorting were altered as revealed by surface biotinylation and immunofluorescence microscopy of fixed nonpermeabilized cells, These results demonstrate the involvement of microtubules in axonal and dendritic transport of integral membrane glycoproteins, and the existence of a BFA-sensitive component in the sorting but not in the transport machinery

Duality between simple-group gauge theories and some applications

In this paper we investigate N=1 supersymmetric gauge theories with a product gauge group. By using smoothly confining dynamics, we can find new dualities which include higher-rank tensor fields, and in which the dual gauge group is simple, not a product. Some of them are dualities between chiral and non-chiral gauge theories. We also discuss some applications to dynamical supersymmetry breaking phenomena and new confining theories with a tree-level superpotential.Comment: 33 pages, LaTeX, references added, version to appear in PR

Probing black hole accretion in quasar pairs at high redshift

Models and observations suggest that luminous quasar activity is triggered by mergers, so it should preferentially occur in the most massive primordial dark matter haloes, where the frequency of mergers is expected to be the highest. Since the importance of galaxy mergers increases with redshift, we identify the high-redshift Universe as the ideal laboratory for studying dual AGN. Here we present the X-ray properties of two systems of dual quasars at z=3.0-3.3 selected from the SDSS-DR6 at separations of 6-8 arcsec (43-65kpc) and observed by Chandra for 65ks each. Both members of each pair are detected with good photon statistics to allow us to constrain the column density, spectral slope and intrinsic X-ray luminosity. We also include a recently discovered dual quasar at z=5 (separation of 21 arcsec, 136kpc) for which XMM-Newton archival data allow us to detect the two components separately. Using optical spectra we derived bolometric luminosities, BH masses and Eddington ratios that were compared to those of luminous SDSS quasars in the same redshift ranges. We find that the brighter component of both pairs at z=3.0-3.3 has high luminosities compared to the distribution of SDSS quasars at similar redshift, with J1622A having an order magnitude higher luminosity than the median. This source lies at the luminous end of the z~3.3 quasar luminosity function. While we cannot conclusively state that the unusually high luminosities of our sources are related to their having a close companion, for J1622A there is only a 3% probability that it is by chance.Comment: MNRAS, in pres

pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells

The interaction between late endocytic structures and microtubules in polarized cells was studied using a procedure previously shown to cause microtubule-dependent redistribution of lysosomes in fibroblasts and macrophages (Heuser, J. 1989. J. Cell Biol. 108:855-864). In cultured rat hippocampal neurons, low cytoplasmic pH caused cation-independent mannose-6-phosphate receptor-enriched structures to move out of the cell body and into the processes. In filter grown MDCK cells lowering the cytosolic pH to approximately 6.5 caused late endosomes to move to the base of the cell and this process was shown to be microtubule dependent. Alkalinization caused a shift in distribution towards the apical pole of the cell. The results are consistent with low pH causing the redistribution of late endosomes towards the plus ends of the microtubules. In MDCK cells the microtubules orientated vertically in the cell may play a role in this process. The shape changes that accompanied the redistribution of the late endosomes in MDCK cells were examined by electron microscopy. On low pH treatment fragmentation of the late endosomes was observed whereas after microtubule depolymerization individual late endosomal structures appeared to fuse together. The late endosomes of the MDCK cell appear to be highly pleomorphic and dependent on microtubules for their form and distribution in the cell

On alternative approaches to Lorentz violation in loop quantum gravity inspired models

Recent claims point out that possible violations of Lorentz symmetry appearing in some semiclassical models of extended matter dynamics motivated by loop quantum gravity can be removed by a different choice of canonically conjugated variables. In this note we show that such alternative is inconsistent with the choice of variables in the underlying quantum theory together with the semiclassical approximation, as long as the correspondence principle is maintained. A consistent choice will violate standard Lorentz invariance. Thus, to preserve a relativity principle in this framework, the linear realization of Lorentz symmetry should be extended or superseded.Comment: 4 pages, revtex4, no figures, references adde

New Confining N=1 Supersymmetric Gauge Theories

We examine N=1 supersymmetric gauge theories which confine in the presence of a tree-level superpotential. We show the confining spectra which satisfy the 't Hooft anomaly matching conditions and give a simple method to find the confining superpotential. Using this method we fix the confining superpotentials in the simplest cases, and show how these superpotentials are generated by multi-instanton effects in the dual theory. These new type of confining theories may be useful for model building, since the size of the matter content is not restricted by an index constraint. Therefore, one expects that a large variety of new confining spectra can be obtained using such models.Comment: 26 pages, LaTe

Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies

Hematologic malignancies provide a suitable testing environment for cell-based immunotherapies, which were pioneered by the development of allogeneic hematopoietic stem cell transplant. All types of cell-based therapies, from donor lymphocyte infusion to dendritic cell vaccines, and adoptive transfer of tumor-specific cytotoxic T cells and natural killer cells, have been clinically translated for hematologic malignancies. The recent success of chimeric antigen receptor-modified T lymphocytes in B-cell malignancies has stimulated the development of this approach toward other hematologic tumors. Similarly, the remarkable activity of checkpoint inhibitors as single agents has created enthusiasm for potential combinations with other cell-based immune therapies. However, tumor cells continuously develop various strategies to evade their immune-mediated elimination. Meanwhile, the recruitment of immunosuppressive cells and the release of inhibitory factors contribute to the development of a tumor microenvironment that hampers the initiation of effective immune responses or blocks the functions of immune effector cells. Understanding how tumor cells escape from immune attack and favor immunosuppression is essential for the improvement of immune cell-based therapies and the development of rational combination approaches

Supersymmetric Gauge Theories with an Affine Quantum Moduli Space

All supersymmetric gauge theories based on simple groups which have an affine quantum moduli space, i.e. one generated by gauge invariants with no relations, W=0, and anomaly matching at the origin, are classified. It is shown that the only theories with no gauge invariants (and moduli space equal to a single point) are the two known examples, SU(5) with 5-bar + 10 and SO(10) with a spinor. The index of the matter representation must be at least as big as the index of the adjoint in theories which have a non-trivial relation among the gauge invariants.Comment: Incorrect proof that theories with constraints must have mu >= mu(adj) replaced by a correct one (6 pages, uses revtex, amssymb, array