How Catastrophic Innovation Failure Affects Organizational and Industry Legitimacy: The 2014 Virgin Galactic Test Flight Crash

We examine how catastrophic innovation failure affects organizational and industry legitimacy in nascent sectors by analyzing the interactions between Virgin Galactic and stakeholders in the space community in the aftermath of the firm’s 2014 test flight crash. Following catastrophic innovation failure, we find that industry participants use their interpretations of the failure to either uphold or challenge the legitimacy of the firm while maintaining the legitimacy of the industry. These dynamics yield two interesting effects. First, we show that, in upholding the legitimacy of the industry, different industry participants rhetorically redraw the boundaries of the industry to selectively include players they consider legitimate and exclude those they view as illegitimate: detracting stakeholders constrain the boundaries of the industry by excluding the firm or excluding the firm and its segment, whereas the firm and supporting stakeholders amplify the boundaries of the industry by including firms in adjacent high-legitimacy sectors. Second, we show that, in assessing organizational legitimacy, the firm and its stakeholders differ in the way they approach distinctiveness between the identities of the industry and the firm. Detracting stakeholders differentiate the firm from the rest of the industry and isolate it, whereas the firm and supporting stakeholders reidentify the firm with the industry, embedding the firm within it. Overall, our findings illuminate the effects that catastrophic innovation failure has over high-order dynamics that affect the evolution of nascent industries

How Firms Frame Catastrophic Innovation Failure

We examine how catastrophic innovation failure affects organizational and industry legitimacy in nascent sectors by analyzing the interactions between Virgin Galactic and stakeholders in the space community in the aftermath of the firm’s 2014 test flight crash. Following catastrophic innovation failure, we find that industry participants use their interpretations of the failure to either uphold or challenge the legitimacy of the firm, while maintaining the legitimacy of the industry. These dynamics yield two interesting effects. First, we show that, in upholding the legitimacy of the industry, different industry participants rhetorically re-draw the boundaries of the industry to selectively include players they consider ‘legitimate’ and exclude those they view as ‘illegitimate:’ detracting stakeholders constrain the boundaries of the industry by excluding the firm or excluding the firm and its segment, while the firm and supporting stakeholders amplify the boundaries of the industry by including firms in adjacent high-legitimacy sectors. Second, we show that, in assessing organizational legitimacy, the firm and its stakeholders differ in the way they approach distinctiveness between the identities of the industry and the firm. Detracting stakeholders differentiate the firm from the rest of the industry and isolate it, while the firm and supporting stakeholders re-identify the firm with the industry, embedding the firm within it. Overall, our findings illuminate the effects that catastrophic innovation failure has over high-order dynamics that affect the evolution of nascent industries

How the Supply of Fake News Affected Consumer Behavior during the 2016 US Election

We characterize the effect of fake news on online browsing during the 2016 US presidential election. We estimate that weekday increases of 10 fake news articles — that were confirmed to be false by third-party services — increased the incidence of fake news site visits by 3.0%. To address endogeneity, we employ two approaches that attempt to isolate exogenous variation in fake news supply. We also estimate that weekday 10-article increases in fake news increase the odds of visiting one or more fake news sites by 3.7%. Overall, this evidence demonstrates the effectiveness of fake news production in reaching a diverse set of consumers

Generative AI enhances individual creativity but reduces the collective diversity of novel content

This is the final version. Available from American Association for the Advancement of Science via the DOI in this record. Data and materials availability: All data and code needed to replicate these analyses are available at Dryad: https://doi.org/10.5061/dryad.qfttdz0pm. All other data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.Creativity is core to being human. Generative artificial intelligence (AI)—including powerful large language models (LLMs)—holds promise for humans to be more creative by offering new ideas, or less creative by anchoring on generative AI ideas. We study the causal impact of generative AI ideas on the production of short stories in an online experiment where some writers obtained story ideas from an LLM. We find that access to generative AI ideas causes stories to be evaluated as more creative, better written, and more enjoyable, especially among less creative writers. However, generative AI–enabled stories are more similar to each other than stories by humans alone. These results point to an increase in individual creativity at the risk of losing collective novelty. This dynamic resembles a social dilemma: With generative AI, writers are individually better off, but collectively a narrower scope of novel content is produced. Our results have implications for researchers, policy-makers, and practitioners interested in bolstering creativity.University of ExeterUniversity College, Londo

Framing Catastrophic Failure as a Learning Opportunity

In recent times, failure has been hailed as a valuable trigger to organizational learning. This is especially true in organizations pursuing radical innovation that address humanity’s grand challenges. For organizations to be able to learn, however, both the organization and its stakeholders must frame failure as a learning instance. By examining an extreme case, we explore how an organization makes strategic use of traditional and social media to influence stakeholders’ meaning-making process in the aftermath of highly visible catastrophic failure. We identify two sets of complementary strategies: Amplifying/Retrenching and Grounding/Elevating. The organization used these strategies to regulate the frequency and type of content it made available to stakeholders. We theorize that the intimacy provided by social media and the formality of established news outlets may, together, contribute to influencing stakeholders to see failure in positive terms and maintain their support

Cardiorespiratory fitness predicts clustered cardiometabolic risk in 10-11.9 year olds

The aim of this study was to investigate levels of clustered cardiometabolic risk and the odds of being ‘at risk’ according to cardiorespiratory fitness status in children. Data from 88 10–11.9-year-old children (mean age 11.05 ± 0.51 years), who participated in either the REACH Year 6 or the Benefits of Fitness Circuits for Primary School Populations studies were combined. Waist circumference, systolic blood pressure, diastolic blood pressure, glucose, triglycerides, high-density lipoprotein cholesterol, adiponectin and C-reactive protein were assessed and used to estimate clustered cardiometabolic risk. Participants were classified as ‘fit’ or ‘unfit’ using recently published definitions (46.6 and 41.9 mL/kg/min for boys and girls, respectively), and continuous clustered risk scores between fitness groups were assessed. Participants were subsequently assigned to a ‘normal’ or ‘high’ clustered cardiometabolic risk group based on risk scores, and logistic regression analysis assessed the odds of belonging to the increased cardiometabolic risk group according to fitness. The unfit group exhibited significantly higher clustered cardiometabolic risk scores (p < 0.001) than the fit group. A clear association between fitness group and being at increased cardiometabolic risk (B = 2.509, p = 0.001) was also identified, and participants classed as being unfit were found to have odds of being classified as ‘at risk’ of 12.30 (95 % CI = 2.64–57.33).\ud \ud Conclusion Assessing cardiorespiratory fitness is a valid method of identifying children most at risk of cardiometabolic pathologies. The ROC thresholds could be used to identify populations of children most at risk and may therefore be used to effectively target a cardiometabolic risk-reducing public health intervention

Influenza A (H1N1) in Victoria, Australia: A Community Case Series and Analysis of Household Transmission

We characterise the clinical features and household transmission of pandemic influenza A (pH1N1) in community cases from Victoria, Australia in 2009.Questionnaires were used to collect information on epidemiological characteristics, illness features and co-morbidities of cases identified in the 2009 Victorian Influenza Sentinel Surveillance program.The median age of 132 index cases was 21 years, of whom 54 (41%) were under 18 years old and 28 (21%) had medical co-morbidities. The median symptom duration was significantly shorter for children who received antivirals than in those who did not (p = 0.03). Assumed influenza transmission was observed in 63 (51%) households. Influenza-like illness (ILI) developed in 115 of 351 household contacts, a crude secondary attack rate of 33%. Increased ILI rates were seen in households with larger numbers of children but not larger numbers of adults. Multivariate analysis indicated contacts of cases with cough and diarrhoea, and contacts in quarantined households were significantly more likely to develop influenza-like symptoms.Most cases of pH1N1 in our study were mild with similar clinical characteristics to seasonal influenza. Illness and case features relating to virus excretion, age and household quarantine may have influenced secondary ILI rates within households

LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability

BACKGROUND: Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently. This study was performed to determine the relationship between DNA hypomethylation, hypermethylation and microsatellite instability in cancer. METHODOLOGY/PRINCIPAL FINDINGS: We examined 61 cancer cell lines and 60 colorectal carcinomas and their adjacent tissues using LINE-1 bisulfite-PCR as a surrogate for global demethylation. Colorectal carcinomas with sporadic microsatellite instability (MSI), most of which are due to a CpG island methylation phenotype (CIMP) and associated MLH1 promoter methylation, showed in average no difference in LINE-1 methylation between normal adjacent and cancer tissues. Interestingly, some tumor samples in this group showed increase in LINE-1 methylation. In contrast, MSI-showed a significant decrease in LINE-1 methylation between normal adjacent and cancer tissues (P<0.001). Microarray analysis of repetitive element methylation confirmed this observation and showed a high degree of variability in hypomethylation between samples. Additionally, unsupervised hierarchical clustering identified a group of highly hypomethylated tumors, composed mostly of tumors without microsatellite instability. We extended LINE-1 analysis to cancer cell lines from different tissues and found that 50/61 were hypomethylated compared to peripheral blood lymphocytes and normal colon mucosa. Interestingly, these cancer cell lines also exhibited a large variation in demethylation, which was tissue-specific and thus unlikely to be resultant from a stochastic process. CONCLUSION/SIGNIFICANCE: Global hypomethylation is partially reversed in cancers with microsatellite instability and also shows high variability in cancer, which may reflect alternative progression pathways in cancer

We should not be complacent about our population-based public health response to the first influenza pandemic of the 21st century

Background: More than a year after an influenza pandemic was declared in June 2009, the World Health Organization declared the pandemic to be over. Evaluations of the pandemic response are beginning to appear in the public domain. Discussion. We argue that, despite the enormous effort made to control the pandemic, it is now time to acknowledge that many of the population-based public health interventions may not have been well considered. Prior to the pandemic, there was limited scientific evidence to support border control measures. In particular no border screening measures would have detected prodromal or asymptomatic infections, and asymptomatic infections with pandemic influenza were common. School closures, when they were partial or of short duration, would not have interrupted spread of the virus in school-aged children, the group with the highest rate of infection worldwide. In most countries where they were available, neuraminidase inhibitors were not distributed quickly enough to have had an effect at the population level, although they will have benefited individuals, and prophylaxis within closed communities will have been effective. A pandemic specific vaccine will have protected the people who received it, although in most countries only a small minority was vaccinated, and often a small minority of those most at risk. The pandemic vaccine was generally not available early enough to have influenced the shape of the first pandemic wave and it is likely that any future pandemic vaccine manufactured using current technology will also be available too late, at least in one hemisphere. Summary. Border screening, school closure, widespread anti-viral prophylaxis and a pandemic-specific vaccine were unlikely to have been effective during a pandemic which was less severe than anticipated in the pandemic plans of many countries. These were cornerstones of the population-based public health response. Similar responses would be even less likely to be effective in a more severe pandemic. We agree with the recommendation from the World Health Organisation that pandemic preparedness plans need review

De novo implantation vs. upgrade cardiac resynchronization therapy: a systematic review and meta-analysis

Patients with conventional pacemakers or implanted defibrillators are often considered for cardiac resynchronization therapy (CRT). Our aim was to summarize the available evidences regarding the clinical benefits of upgrade procedures. A systematic literature search was performed from studies published between 2006 and 2017 in order to compare the outcome of CRT upgrade vs. de novo implantations. Outcome data on all-cause mortality, heart failure events, New York Heart Association (NYHA) Class, QRS narrowing and echocardiographic parameters were analysed. A total of 16 reports were analysed comprising 489,568 CRT recipients, of whom 468,205 patients underwent de novo and 21,363 upgrade procedures. All-cause mortality was similar after CRT upgrade compared to de novo implantations (RR 1.19, 95% CI 0.88-1.60, p = 0.27). The risk of heart failure was also similar in both groups (RR 0.96, 95% CI 0.70-1.32, p = 0.81). There was no significant difference in clinical response after CRT upgrade compared to de novo implantations in terms of improvement in left ventricular ejection fraction (DeltaEF de novo - 6.85% vs. upgrade - 9.35%; p = 0.235), NYHA class (DeltaNYHA de novo - 0.74 vs. upgrade - 0.70; p = 0.737) and QRS narrowing (DeltaQRS de novo - 9.6 ms vs. upgrade - 29.5 ms; p = 0.485). Our systematic review and meta-analysis of currently available studies reports that CRT upgrade is associated with similar risk for all-cause mortality compared to de novo resynchronization therapy. Benefits on reverse remodelling and functional capacity improved similarly in both groups suggesting that CRT upgrade may be safely and effectively offered in routine practice. CLINICAL TRIAL REGISTRATION: Prospero Database-CRD42016043747