58 research outputs found
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Discrete nodal integral transport-theory method for multidimensional reactor physics and shielding calculations
A coarse-mesh discrete nodal integral transport theory method has been developed for the efficient numerical solution of multidimensional transport problems of interest in reactor physics and shielding applications. The method, which is the discrete transport theory analogue and logical extension of the nodal Green's function method previously developed for multidimensional neutron diffusion problems, utilizes the same transverse integration procedure to reduce the multidimensional equations to coupled one-dimensional equations. This is followed by the conversion of the differential equations to local, one-dimensional, in-node integral equations by integrating back along neutron flight paths. One-dimensional and two-dimensional transport theory test problems have been systematically studied to verify the superior computational efficiency of the new method
Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations
Our understanding of the etiology and pathophysiology of endometriosis remains limited. Disease modelling in the field is problematic as many versions of induced mouse models of endometriosis exist. We integrated bioluminescent imaging of âlesionsâ generated using luciferase-expressing donor mice. We compared longitudinal bioluminescence and histology of lesions, sensory behavior of mice with induced endometriosis and the impact of the GnRH antagonist Cetrorelix on lesion regression and sensory behavior. Four models of endometriosis were tested. We found that the nature of the donor uterine material was a key determinant of how chronic the lesions were as well as their cellular composition. The severity of pain-like behavior also varied across models. Whilst Cetrorelix significantly reduced lesion bioluminescence in all models, it had varying impacts on pain-like behavior. Collectively, our results demonstrate key differences in the progression of the âdiseaseâ across different mouse models of endometriosis. We propose that validation and testing in multiple models, each of which may be representative of the different subtypes / heterogeneity observed in women should become a standard approach to discovery science in the field of endometriosis
Changing foreign policy: the Obama Administrationâs decision to oust Mubarak
This paper analyses the decision of the Obama administration to redirect its
foreign policy towards Egypt in the wake of the Arab Spring. It attempts to
highlight the issue of how governments deal with decision-making at times of
crisis, and under which circumstances they take critical decisions that lead to
major shifts in their foreign policy track record. It focuses on the process that
led to a reassessment of US (United States) foreign policy, shifting from decades
of support to the autocratic regime of Hosni Mubarak, towards backing his
ouster. Specifically, the paper attempts to assess to what extent the decision to
withdraw US support from a longstanding state-leader and ally in the Middle
East can be seen as a foreign policy change (FPC). A relevant research question
this paper pursues is: how can the withdrawal of US support to a regime
considered as an ally be considered, in itself, as a radical FPC
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease
Determining the genetic bases of age-related disease remains a major challenge requiring a spectrum of approaches from human and clinical genetics to the utilization of model organism studies. Here we report a large-scale genetic screen in mice employing a phenotype-driven discovery platform to identify mutations resulting in age-related disease, both late-onset and progressive. We have utilized N-ethyl-N-nitrosourea mutagenesis to generate pedigrees of mutagenized mice that were subject to recurrent screens for mutant phenotypes as the mice aged. In total, we identify 105 distinct mutant lines from 157 pedigrees analysed, out of which 27 are late-onset phenotypes across a range of physiological systems. Using whole-genome sequencing we uncover the underlying genes for 44 of these mutant phenotypes, including 12 late-onset phenotypes. These genes reveal a number of novel pathways involved with age-related disease. We illustrate our findings by the recovery and characterization of a novel mouse model of age-related hearing loss
CARBONATE DEPOSITIONAL ENVIRONMENTS, SEQUENCE STRATIGRAPHY AND EXCEPTIONAL SKELETAL PRESERVATION IN THE MUCH WENLOCK LIMESTONE FORMATION (SILURIAN) OF DUDLEY, ENGLAND
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