RATIONALIZING THE TECHNICAL AND TECHNOLOGICAL PARAMETERS OF SEA BUCKTHORN REFINING EQUIPMENT

Conforming the severe continental weather, wild sea buckthorn clasps in a 14-thousand-hectare area around the river basin, the valley of Mongolia. Moreover, sea buckthorn was planted in 3900 hectares of field, 1.701.278 kg of sea buckthorn was harvested as of 2018. People tend to spend more time and man force refining the sea buckthorn from the waste matter. Thus, the authors set the goal to invent the refining equipment for sea buckthorn and rationalize the parameters f the equipment. For instance, the equipment refines 3.5kg of fruit, blast speed is 10 m/sec, and winnowing fluctuation is 80 min-1. Also, we defined the optimal value and made mathematical modeling of the refinement degree of the sea buckthorn

Bifurcation analysis of a model of the budding yeast cell cycle

We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae. We show that Clb2-dependent kinase exhibits bistability (stable steady states of high or low kinase activity). The transition from low to high Clb2-dependent kinase activity is driven by transient activation of Cln2-dependent kinase, and the reverse transition is driven by transient activation of the Clb2 degradation machinery. We show that a four-variable model retains the main features of the nine-variable model. In a three-variable model exhibiting birhythmicity (two stable oscillatory states), we explore possible effects of extrinsic fluctuations on cell cycle progression.Comment: 31 pages,13 figure

横方向選択成長によるSi基板上への単結晶ダイヤモンド成長に関する研究

電気通信大学201

RESULTS OF DETERMINING OF SOME PHYSICAL AND MECHANICAL PARAMETERS OF MIXED FEEDS, PREPARED BY TMR TECHNOLOGY

Our country has been supporting the intensified cattle farms by policies and establishing as more farms in order to stabilize the population food supply and reduce the seasonal dependence of strategic food. The highly developed countries have been commonly using the TMR fodder technology for the intensified animal husbandry. This article analyses the main parameters of the usage and technological operation of the TMR fodder machines

Equity in tourism development: procedural (in)justice and distributive justice in Mongolia, East Asia

This paper considers procedural justice and distributive justice as a means of examining equity in tourism development. The geographical focus of the paper is Mongolia - historically a unitary sovereign socialist state in East Asia that, in common with Central Asian republics and in contrast to other parts of the eastern sub-region of the Asian continent (China, Korea, Japan and Taiwan), has been shaped by Stalinist Soviet Union policies. This particular context is interesting not only in terms of consolidation of power, and economic, political and social transition, but also with respect to the nature of material wealth and livelihood options. Equity in tourism development in two rural Mongolian regions is explored with specific reference to the concepts of procedural justice and distributive justice. Drawing on political ecology and actor-oriented approaches, the paper considers equity from the perspectives of five actor groups: local grassroots, people in two geographical areas; private sector tourism operators; Government officials; International Development Organisations and academics; and NGOs. Three periods of fieldwork were conducted, providing qualitative interview data, complemented by non-participant observations, and secondary data. Framework analysis is applied as an analytic induction tool. Five emergent themes are discussed here relating to procedural (in)justice and distributive justice. Inequity was perceived to be rooted more strongly in the processes of tourism development rather than in the outcomes but the inter-related nature of process and outcome, linked to opportunities and capabilities, is noted (Sen, 1984; 1992; 1999)

EXPERIMENTAL RESULTS OF CURD CUTTING EQUIPMENT

In order to cut the curd prepared in the traditional way in a short time and evenly, a curd cutting device was developed and the distance between the wires of the device was determined depending on the shrinkage coefficient of the curd. The cow's milk of a herder household in Tuv aimag is processed in the traditional way, yoghurt is prepared, the curd is placed on a yam cloth and pumped to a moisture content of 60%. Samples with the same amount of cut curd were dried in a desiccator at 50 ° C for 10 h and the weight and moisture content were determined every hour. As a result of the drying test, the weight of the curd stabilized after 7 hours, and the moisture content reached 20%, reaching the standard value. The linear size of the curds sampled after drying decreased by 16 to 23 percent and the linear shrinkage coefficient of the curds was 0.0274

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contribute to resistance to various anticancer drugs, whereas down-regulation of APE1 sensitizes cells to DNA damaging agents. Thus, inhibiting APE1 repair endonuclease function in cancer cells is considered a promising strategy to overcome therapeutic agent resistance. Despite ongoing efforts, inhibitors of APE1 with adequate drug-like properties have yet to be discovered. Using a kinetic fluorescence assay, we conducted a fully-automated high-throughput screen (HTS) of the NIH Molecular Libraries Small Molecule Repository (MLSMR), as well as additional public collections, with each compound tested as a 7-concentration series in a 4 µL reaction volume. Actives identified from the screen were subjected to a panel of confirmatory and counterscreen tests. Several active molecules were identified that inhibited APE1 in two independent assay formats and exhibited potentiation of the genotoxic effect of methyl methanesulfonate with a concomitant increase in AP sites, a hallmark of intracellular APE1 inhibition; a number of these chemotypes could be good starting points for further medicinal chemistry optimization. To our knowledge, this represents the largest-scale HTS to identify inhibitors of APE1, and provides a key first step in the development of novel agents targeting BER for cancer treatment