5,439 research outputs found
Simple colorimetric method determines uranium in tissue
Simple colorimetric micromethod determines concentrations of uranium in tissue. The method involves dry ashing organic extraction, and colorimetric determination of uranyl ferrocyanide. This uranium determination technique could be used in agricultural research, tracer studies, testing of food products, or medical research
<investigation of radar echoes from the moon planets, using methods and data from earth radar-return studies< semiannual status report, 1 nov. 1964 - 30 apr. 1965
Differential reflectivity for estimating surface properties of reflecting body - radar signal reflectio
Investigation of radar echoes from the moon and planets, using methods and data from earth radar-return studies Semiannual status report, 1 May - 31 Oct. 1965
Monostatic reflection from statistically rough sphere, electromagnetic properties of smooth sphere from bistatic power measurement, and acoustic differential reflectivity developmen
4D, N = 1 Supersymmetry Genomics (I)
Presented in this paper the nature of the supersymmetrical representation
theory behind 4D, N = 1 theories, as described by component fields, is
investigated using the tools of Adinkras and Garden Algebras. A survey of
familiar matter multiplets using these techniques reveals they are described by
two fundamental valise Adinkras that are given the names of the cis-Valise
(c-V) and the trans-Valise (t-V). A conjecture is made that all off-shell 4D, N
= 1 component descriptions of supermultiplets are associated with two integers
- the numbers of c-V and t-V Adinkras that occur in the representation.Comment: 53 pages, 19 figures, Report-II of SSTPRS 2008 Added another chapter
for clarificatio
Group B streptococcal infection and activation of human astrocytes.
BACKGROUND:Streptococcus agalactiae (Group B Streptococcus, GBS) is the leading cause of life-threatening meningitis in human newborns in industrialized countries. Meningitis results from neonatal infection that occurs when GBS leaves the bloodstream (bacteremia), crosses the blood-brain barrier (BBB), and enters the central nervous system (CNS), where the bacteria contact the meninges. Although GBS is known to invade the BBB, subsequent interaction with astrocytes that physically associate with brain endothelium has not been well studied. METHODOLOGY/PRINCIPAL FINDINGS:We hypothesize that human astrocytes play a unique role in GBS infection and contribute to the development of meningitis. To address this, we used a well- characterized human fetal astrocyte cell line, SVG-A, and examined GBS infection in vitro. We observed that all GBS strains of representative clinically dominant serotypes (Ia, Ib, III, and V) were able to adhere to and invade astrocytes. Cellular invasion was dependent on host actin cytoskeleton rearrangements, and was specific to GBS as Streptococcus gordonii failed to enter astrocytes. Analysis of isogenic mutant GBS strains deficient in various cell surface organelles showed that anchored LTA, serine-rich repeat protein (Srr1) and fibronectin binding (SfbA) proteins all contribute to host cell internalization. Wild-type GBS also displayed an ability to persist and survive within an intracellular compartment for at least 12 h following invasion. Moreover, GBS infection resulted in increased astrocyte transcription of interleukin (IL)-1β, IL-6 and VEGF. CONCLUSIONS/SIGNIFICANCE:This study has further characterized the interaction of GBS with human astrocytes, and has identified the importance of specific virulence factors in these interactions. Understanding the role of astrocytes during GBS infection will provide important information regarding BBB disruption and the development of neonatal meningitis
Letter from P. A. Doran to John Muir, 1903 Apr 21
San Francisco April 21st 1903 Professor John Muir. Martinez My Dear Professor Leaving here Thursday morning next with the Columbia will be my last trip for some time, and I go east from Portland, and possibly heave to in Europe/ Mrs. Doran will be accompanying me. I intended calling on you last month, but the annual drydocking and overhauling threw us so far behind thime that it looks nearly like the whole month to catch our old schedule. And this month Mrs. Doran has been busy preparing for our journey. I am sorry I canΓÇÖt see Helen before I leave, as I have some huge stories of our friends the ΓÇ£Huge Levithians of the deep.ΓÇ¥ But I will expect to see some on the Atlantic and will tell her all about them when I return. Mrs. Doran joins me in kindest regards to yourself and your family. Wishing you a successful voyage and that you may discover several new ΓÇ£Huge LeviathasrsΓÇ¥ I am Sincerely yours P. A. Doran S.S. Columbi
- …