319 research outputs found
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A new approach to planning in vitro and in vivo experiments for cardiovascular stents. (1) Fundamentals of design procedures
Copyright @ 2000 Pacini Editore SpAWhile the use of cardiovascular stents is internationally widespread re-stenosis remains a common problem. There are a number of different designs, and this project seeks for design improvements leading to a reduction in re-stenosis rates. The haemodynamics of the stent as used in a patient is viewed as one of the major concerns, and the authors have already applied Computational Fluid Dynamics in investigating this. In this more comprehensive study, however, the novel approach of applying two formal engineering design procedures is used, namely Genetic Algorithms (GA) and Robust Engineering Design (RED). In this paper, the two procedures are explained and compared in the context of their application to the design of stents
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A new approach to planning in vitro and in vivo experiments for cardiovascular stents. (2) Planning of experiments
Copyright @ 2000 Pacini Editore SpAWithin our overall project to improve the design of stents in terms of reduced rates of re-stenosis, there are three main methods, namely computer simulation and in vitro and in vivo experiments. These methods are closely integrated using contemporary design procedures described below, especially to accommodate patient-to-patient variation. Clinical experience shows that a small variation has considerable effects on flow characteristics of stents and in engineering terms may be described as a ‘geometric risk factor’. The Robust Engineering Design procedure readily incorporates this factor which may thus become a component feature in our experimental planning. We envisage that this approach could be applied to other invasive implants with a view to enhancing their quality
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A new approach to planning in vitro and in vivo experiments for cardiovascular stents – II. Planning of experiment (abstract)
Within our overall project to improve the design of stents in terms of reduced rates of re-stenosis, there are three main methods, namely computer simulation and in vitro and in vivo experiments. These methods are closely integrated using contemporary design procedures described below, especially to accommodate patient-to-patient variation. Clinical experience shows that a small variation has considerable effects on flow characteristics of stents and in engineering terms may be described as a ‘geometric risk factor’. The Robust Engineering Design procedure readily incorporates this factor which may thus become a component feature in our experimental planning. We envisage that this approach could be applied to other invasive implants with a view to enhancing their quality
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