Studying the potential of the [OII] emission line as a surrogate for stellar velocity dispersion in Active Galactic Nuclei

We study the emission profiles of 80 active galaxies to find a surrogate for stellar velocity dispersion. We focus on the width of the emission line of once ionized oxygen, [OII], and compare our results to previous work that used [OIII]. In previous research, [OIII] was found to be a good candidate for a surrogate for stellar velocity dispersion, but analysis of the line was complicated by the presence of wings caused by gas infall and outflow in the region. Emission lines with lower ionization levels, like [OII], are known to have less artificial line-broadening from wings. The study of [OIII] used a double Gaussian profile in an attempt to remove the wings. Here we simply fit the [OII] doublet line with two single Gaussian profiles at fixed separation and width. The main benefits of the [OII] line over the [OIII] line are the simpler fitting process, and the fact that [OII] is in a quiet region on the spectra with little interference from other emission lines. We found that the [OII] line still showed wings significant enough to require a fitting of these wings. [OIII] still appears to be the best candidate for a surrogate for stellar velocity dispersion

Prospectus, September 14, 1973

NEW CAMPUS TO HOUSE RECORD ENROLLMENT: PARKLAND COLLEGE BEGINS 7TH YEAR; Large Turnout Expected During Activities Week; Tom Neal Wounded In Campus Shooting; Name The Newspaper Contest; Prospectus in Perspective: Toward Humanistic Reporting; Board Seeks More Student Involvement in Publications; Something of Value; From the Adviser; Measure For Measure; Student Clubs Provide Array Of Opportunities; Student Charters To Be Examined; Campus Artist Needed For Cartoon Series; Placement Bureau Provides Vital Service; Vet\u27s Club Elections; Vet\u27s Used Books; Literary Magazine Expands Publication; Campus Maze Baffles Students, President Delivers Advice; Prospectus Code of Ethics; Krannert Art Center Schedule; Parkland College Campus Guide: A Warm Welcome to Parkland College, Directory of Offices and Services, Key to Locations, Items of Interest About the New Campus, Guidelines Committee Makes Recommendations; Debate: Last Of The Academic Classics; Classified Ads; New Faculty Members Join Parkland Team; Cobra Cross-Country Team Opens Competition; Veteran\u27s Meeting; Linksmen Still Needed For PC Opening Match; Faculty Bowling Commences Today; Faculty Softball Team Wins Third In Mahomet Tournament; Fast Freddy\u27s Football Forecast; \u27Punt, Pass, Kick\u27 Added Attraction For Intramurals; Senatorial Campaigns To Be Launched: Elections In October; Board Appoints New Adviser; Salaries Awarded Staff Members; Forthcoming Issues; Prospectus Staff Meeting; Convocations Plans Variety Entertainment; Callboard; September Calendar Of Eventshttps://spark.parkland.edu/prospectus_1973/1006/thumbnail.jp

Engraftment Syndrome after Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation: Incidence and Effects on Survival

AbstractEngraftment syndrome (ES) encompasses a constellation of symptoms that occur during neutrophil recovery after both autologous and allogeneic hematopoietic stem cell transplantation (HCT). Although it is well characterized after conventional myeloablative procedures, limited data exist on this complication after nonmyeloablative allogeneic HCT. The clinical manifestations, incidence, and risk factors associated with ES were investigated in a consecutive series of patients undergoing cyclophosphamide/fludarabine-based nonmyeloablative allogeneic HCT from a related HLA-compatible donor. Fifteen (10%) of 149 patients (median age, 53 years; range, 27–66 years) developed ES; the onset of symptoms occurred at a median of 10 days (range, 3–14 days), and they consisted of fever (100%), cough (53%), diffuse pulmonary infiltrates (100%), rash (13%), and room air hypoxia (87%). ES was more likely to develop in patients who received empiric amphotericin formulations after transplant conditioning (Fisher exact test; P = .007). In a multivariate analysis, older patient age, female sex, and treatment with amphotericin were predictors for the development of ES. Intravenous methylprednisolone led to the rapid resolution of ES; however, transplant-related mortality was significantly higher (cumulative incidence, 49% versus 16%; P = .0005), and median survival was significantly shorter (168 versus 418 days; P = .005) in patients with ES compared with non-ES patients. In conclusion, ES occurs commonly after cyclophosphamide/fludarabine-based nonmyeloablative transplantation and responds rapidly to corticosteroid treatment, but it is associated with a higher risk of nonrelapse mortality and with shorter overall survival

py4DSTEM: a software package for multimodal analysis of four-dimensional scanning transmission electron microscopy datasets

Scanning transmission electron microscopy (STEM) allows for imaging, diffraction, and spectroscopy of materials on length scales ranging from microns to atoms. By using a high-speed, direct electron detector, it is now possible to record a full 2D image of the diffracted electron beam at each probe position, typically a 2D grid of probe positions. These 4D-STEM datasets are rich in information, including signatures of the local structure, orientation, deformation, electromagnetic fields and other sample-dependent properties. However, extracting this information requires complex analysis pipelines, from data wrangling to calibration to analysis to visualization, all while maintaining robustness against imaging distortions and artifacts. In this paper, we present py4DSTEM, an analysis toolkit for measuring material properties from 4D-STEM datasets, written in the Python language and released with an open source license. We describe the algorithmic steps for dataset calibration and various 4D-STEM property measurements in detail, and present results from several experimental datasets. We have also implemented a simple and universal file format appropriate for electron microscopy data in py4DSTEM, which uses the open source HDF5 standard. We hope this tool will benefit the research community, helps to move the developing standards for data and computational methods in electron microscopy, and invite the community to contribute to this ongoing, fully open-source project

Studying the [OIII]λ\lambda5007A emission-line width in a sample of ∼\sim80 local active galaxies: A surrogate for σ⋆\sigma_{\star}?

For a sample of $\sim$80 local ($0.02 \leq z \leq 0.1$) Seyfert-1 galaxies with high-quality long-slit Keck spectra and spatially-resolved stellar-velocity dispersion ($\sigma_{\star}$) measurements, we study the profile of the [OIII]$\lambda$5007A emission line to test the validity of using its width as a surrogate for $\sigma_{\star}$. Such an approach has often been used in the literature, since it is difficult to measure $\sigma_{\star}$ for type-1 active galactic nuclei (AGNs) due to the AGN continuum outshining the stellar-absorption lines. Fitting the [OIII] line with a single Gaussian or Gauss-Hermite polynomials overestimates $\sigma_{\star}$ by 50-100%. When line asymmetries from non-gravitational gas motion are excluded in a double Gaussian fit, the average ratio between the core [OIII] width ($\sigma_{\rm {[OIII],D}}$) and $\sigma_{\star}$ is $\sim$1, but with individual data points off by up to a factor of two. The resulting black-hole-mass-$\sigma_{\rm {[OIII],D}}$ relation scatters around that of quiescent galaxies and reverberation-mapped AGNs. However, a direct comparison between $\sigma_{\star}$ and $\sigma_{\rm {[OIII],D}}$ shows no close correlation, only that both quantities have the same range, average and standard deviation, probably because they feel the same gravitational potential. The large scatter is likely due to the fact that line profiles are a luminosity-weighted average, dependent on the light distribution and underlying kinematic field. Within the range probed by our sample (80-260 km s$^{-1}$), our results strongly caution against the use of [OIII] width as a surrogate for $\sigma_{\star}$ on an individual basis. Even though our sample consists of radio-quiet AGNs, FIRST radio-detected objects have, on average, a $\sim$10% larger [OIII] core width.Comment: 15 pages, 10 figures, 6 tables. Accepted for publication in the Monthly Notices of the Royal Astronomical Societ

A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

Abstract Background Long-acting muscarinic antagonist/long-acting β 2 -agonist combinations are recommended for patients whose chronic obstructive pulmonary disease (COPD) is not managed with monotherapy. We assessed the efficacy and safety of glycopyrrolate (GP)/formoterol fumarate (FF) fixed-dose combination delivered via a Co-Suspension™ Delivery Technology-based metered dose inhaler (MDI) (GFF MDI). Methods This was a Phase IIb randomized, multicenter, placebo-controlled, double-blind, chronic-dosing (7 days), crossover study in patients with moderate-to-very severe COPD (NCT01085045). Treatments included GFF MDI twice daily (BID) (GP/FF 72/9.6 μg or 36/9.6 μg), GP MDI 36 μg BID, FF MDI 7.2 and 9.6 μg BID, placebo MDI, and open-label formoterol dry powder inhaler (FF DPI) 12 μg BID or tiotropium DPI 18 μg once daily. The primary endpoint was forced expiratory volume in 1 s area under the curve from 0 to 12 h (FEV 1 AUC 0–12 ) on Day 7 relative to baseline FEV 1 . Secondary endpoints included pharmacokinetics and safety. Results GFF MDI 72/9.6 μg or 36/9.6 μg led to statistically significant improvements in FEV 1 AUC 0–12 after 7 days’ treatment versus monocomponent MDIs, placebo MDI, tiotropium, or FF DPI (p ≤ 0.0002). GFF MDI 36/9.6 μg was non-inferior to GFF MDI 72/9.6 μg and monocomponent MDIs were non-inferior to open-label comparators. Pharmacokinetic results showed glycopyrrolate and formoterol exposure were decreased following administration via fixed-dose combination versus monocomponent MDIs; however, this was not clinically meaningful. GFF MDI was well tolerated. Conclusions GFF MDI 72/9.6 μg and 36/9.6 μg BID improve lung function and are well tolerated in patients with moderate-to-very severe COPD. Trial registration ClinicalTrials.gov NCT01085045. Registered 9 March 2010

Choral Ensembles Holiday Concert, Hodie Christus natus est

KSU School of Music presents Choral Ensembles Holiday Concert, Hodie Christus natus est.https://digitalcommons.kennesaw.edu/musicprograms/1186/thumbnail.jp

Chamber Singers, Men\u27s Ensemble and University Chorale, Requiem for the Living

KSU School of Music presents Chamber Singers, Men\u27s Ensemble and University Chorale directed by Dr. Leslie Blackwell, Director of Choral Activities and Professor of Music and Music Education.https://digitalcommons.kennesaw.edu/musicprograms/2033/thumbnail.jp

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds to ∼4,900 RNAs enriched for GGUA motifs in adult mouse brains. TAF15 and FUS exhibit similar binding patterns in introns, are enriched in 3′ untranslated regions and alter genes distinct from TDP-43. However, unlike FUS and TDP-43, TAF15 has a minimal role in alternative splicing. In human neural progenitors, TAF15 and FUS affect turnover of their RNA targets. In human stem cell-derived motor neurons, the RNA profile associated with concomitant loss of both TAF15 and FUS resembles that observed in the presence of the ALS-associated mutation FUS R521G, but contrasts with late-stage sporadic ALS patients. Taken together, our findings reveal convergent and divergent roles for FUS, TAF15 and TDP-43 in RNA metabolism.National Institutes of Health (U.S.) (Grant HG007005