Mass inflation in f(R) gravity: A conjecture on the resolution of the mass inflation singularity

We study gravitational collapse of a charged black hole in f(R) gravity using double-null formalism. We require cosmological stability to f(R) models; we used the Starobinsky model and the R + (1/2)cR^2 model. Charged black holes in f(R) gravity can have a new type of singularity due to higher curvature corrections, the so-called f(R)-induced singularity, although it is highly model-dependent. As the advanced time increases, the internal structure will approach the Cauchy horizon, which may not be an inner apparent horizon. There is mass inflation as one approaches the Cauchy horizon and hence the Cauchy horizon may be a curvature singularity with nonzero area. However, the Ricci scalar is finite for an out-going null observer. This can be integrated as follows: Cosmologically stable higher curvature corrections of the Ricci scalar made it bounded even in the presence of mass inflation. Finally, we conjecture that if there is a general action including general higher curvature corrections with cosmological stability, then the corrections can make all curvature components finite even in the presence of mass inflation. This might help us to resolve the problem of inner horizon instability of regular black hole models.Comment: 31 pages, 15 figure

Euclidean quantum gravity and stochastic inflation

In this paper, we compare dispersions of a scalar field in Euclidean quantum gravity with stochastic inflation. We use Einstein gravity and a minimally coupled scalar field with a quadratic potential. We restrict our attention to small mass and small field cases. In the Euclidean approach, we introduce the ground state wave function which is approximated by instantons. We used a numerical technique to find instantons that satisfy classicality. In the stochastic approach, we introduce the probability distribution of Hubble patches that can be approximated by locally homogeneous universes down to a smoothing scale. We assume that the ground state wave function should correspond to the stationary state of the probability distribution of the stochastic Universe. By comparing the dispersion of both approaches, we conclude three main results. (1) For a statistical distribution with a certain value, we can find a corresponding instanton in the Euclidean side, and it should be a complex-valued instanton. (2) The size of the Universe of the Euclidean approach corresponds to the smoothing scale of the stochastic side; the Universe is homogeneous up to the Euclidean instanton. (3) In addition, as the mass increases up to a critical value, both approaches break at the same time. Hence, generation of classical inhomogeneity in the stochastic approach and the instability of classicality in the Euclidean approach are related.open2

Cosmesis and feasibility of transvaginal natural orifice Specimen extraction (NOSE) for large organ specimen: a prospective pilot study

This study aimed to evaluate cosmetic outcomes and feasibility of transvaginal natural orifice specimen extraction (NOSE) in patients who underwent laparoscopic or robotic surgery for the treatment of benign or malignant diseases of the kidney, liver, stomach, adrenal gland, and bladder. Methods This prospective study was conducted at a tertiary hospital between March 2015 and May 2020. The main outcome was cosmetic outcomes of scars assessed using the Patient and Observer Scar Assessment Scale (POSAS) 1 and 8 weeks after surgery. The secondary outcomes were postoperative pain, operating time, and complications. Sexual function was assessed using the Female Sexual Function Index (FSFI) questionnaire 6 months after surgery in 17 patients who were sexually active at the time of surgery. Results A total of 38 transvaginal NOSE procedures were performed for the extraction of 33 kidneys, 2 livers, 1 stomach, 1 adrenal gland, and 1 bladder. Observers rated pigmentation and relief scores as most deviant from normal skin (2.9 ± 1.7, 3.0 ± 2.1 at postoperative 1 week; 3.6 ± 1.9, 3.5 ± 2.2 at postoperative 8 weeks, respectively), but the overall scores of each item were low. The patients overall satisfaction with postoperative scars was high, and the mean scores for pain and itching were low, with significant improvement from the first week to the eighth week (P = 0.014 and P = 0.006, respectively). Patients also reported low scores on vaginal assessment items, indicating better symptoms, and bleeding improved significantly between the two time points (P = 0.001). Postoperative pain was reduced from moderate during the first 24h after surgery to mild after 24h. The mean operative time of the transvaginal NOSE procedure was 28.3 ± 13.3min. No postoperative complications were associated with the procedure. The mean FSFI total score was 21.2 ± 8.7 (cutoff score for dysfunction is 21), with higher scores indicating better sexual functioning. Conclusion Transvaginal NOSE seems to be a feasible procedure with promising cosmetic benefits, for patients who undergo minimally invasive surgery for large organs including the kidney, liver, stomach, adrenal gland, and bladder. A prospective randomized clinical trial is needed to provide solid evidence to support transvaginal NOSE. Trial registration: This trial is registered at ClinicalTrials.gov (NCT05113134).This study was supported by a grant (no. 02-2014-0055) from the Seoul National University Bundang Hospital Research Fund. The funding source played no role in the study design, collection, analysis, or interpretation of the data, writing of the report, or decision to submit the article

Structural and optical properties of ZnS thin films deposited by RF magnetron sputtering

Zinc sulfide [ZnS] thin films were deposited on glass substrates using radio frequency magnetron sputtering. The substrate temperature was varied in the range of 100°C to 400°C. The structural and optical properties of ZnS thin films were characterized with X-ray diffraction [XRD], field emission scanning electron microscopy [FESEM], energy dispersive analysis of X-rays and UV-visible transmission spectra. The XRD analyses indicate that ZnS films have zinc blende structures with (111) preferential orientation, whereas the diffraction patterns sharpen with the increase in substrate temperatures. The FESEM data also reveal that the films have nano-size grains with a grain size of approximately 69 nm. The films grown at 350°C exhibit a relatively high transmittance of 80% in the visible region, with an energy band gap of 3.79 eV. These results show that ZnS films are suitable for use as the buffer layer of the Cu(In, Ga)Se2 solar cells

Comparison of total body irradiation-based or non-total body irradiation-based conditioning regimens for allogeneic stem cell transplantation in pediatric leukemia patients

Purpose : This study aims to compare the outcome of total body irradiation (TBI)- or non-TBI-containing conditioning regimens for leukemia in children. Methods : We retrospectively evaluated 77 children conditioned with TBI (n=40) or non-TBI (n=37) regimens, transplanted at Chonnam National University Hospital between January 1996 and December 2007. The type of transplantation, disease status at the time of transplant, conditioning regimen, engraftment kinetics, development of graft-versus-host disease (GVHD), complications, cause of deaths, overall survival (OS), and event-free survival (EFS) were compared between the 2 groups. Results : Among 34 patients with acute lymphoblastic leukemia (ALL), 28 (82.4%) were in the TBI group, while 72.7% (24/33) of patients with myeloid leukemia were in the non-TBI group. Although the 5-year EFS of the 2 groups was similar for all patients (62% vs 63%), the TBI group showed a better 5-year EFS than the non-TBI group when only ALL patients were analyzed (65% vs 17%&#59; P =0.005). In acute myelogenous leukemia patients, the non-TBI group had better survival tendency (73% vs 38%&#59; P=0.089). The incidence of GVHD, engraftment, survival, cause of death, and late complications was not different between the 2 groups. Conclusion : The TBI and non-TBI groups showed comparable results, but the TBI group showed a significantly higher 5-year EFS than the non-TBI group in ALL patients. Further prospective, randomized controlled studies involving larger number of patients are needed to assess the late-onset complications and to compare the socioeconomic quality of life

Recombinant mussel proximal thread matrix protein promotes osteoblast cell adhesion and proliferation

BACKGROUND: von Willebrand factor (VWF) is a key load bearing domain for mamalian cell adhesion by binding various macromolecular ligands in extracellular matrix such as, collagens, elastin, and glycosaminoglycans. Interestingly, vWF like domains are also commonly found in load bearing systems of marine organisms such as in underwater adhesive of mussel and sea star, and nacre of marine abalone, and play a critical load bearing function. Recently, Proximal Thread Matrix Protein1 (PTMP1) in mussel composed of two vWF type A like domains has characterized and it is known to bind both mussel collagens and mammalian collagens. RESULTS: Here, we cloned and mass produced a recombinant PTMP1 from E. coli system after switching all the minor codons to the major codons of E. coli. Recombinant PTMP1 has an ability to enhance mouse osteoblast cell adhesion, spreading, and cell proliferation. In addition, PTMP1 showed vWF-like properties as promoting collagen expression as well as binding to collagen type I, subsequently enhanced cell viability. Consequently, we found that recombinant PTMP1 acts as a vWF domain by mediating cell adhesion, spreading, proliferation, and formation of actin cytoskeleton. CONCLUSIONS: This study suggests that both mammalian cell adhesion and marine underwater adhesion exploits a strong vWF-collagen interaction for successful wet adhesion. In addition, vWF like domains containing proteins including PTMP1 have a great potential for tissue engineering and the development of biomedical adhesives as a component for extra-cellular matrix

The no-boundary measure in string theory: Applications to moduli stabilization, flux compactification, and cosmic landscape

We investigate the no-boundary measure in the context of moduli stabilization. To this end, we first show that for exponential potentials, there are no classical histories once the slope exceeds a critical value. We also investigate the probability distributions given by the no-boundary wave function near maxima of the potential. These results are then applied to a simple model that compactifies 6D to 4D (HBSV model) with fluxes. We find that the no-boundary wave function effectively stabilizes the moduli of the model. Moreover, we find the a priori probability for the cosmological constant in this model. We find that a negative value is preferred, and a vanishing cosmological constant is not distinguished by the probability measure. We also discuss the application to the cosmic landscape. Our preliminary arguments indicate that the probability of obtaining anti de Sitter space is vastly greater than for de Sitter.Comment: 27 pages, 8 figure

No-boundary measure and preference for large e-foldings in multi-field inflation

The no-boundary wave function of quantum gravity usually assigns only very small probability to long periods of inflation. This was a reason to doubt about the no-boundary wave function to explain the observational universe. We study the no-boundary proposal in the context of multi-field inflation to see whether the number of fields changes the situation. For a simple model, we find that indeed the no-boundary wave function can give higher probability for sufficient inflation, but the number of fields involved has to be very high.Comment: 16 pages, 2 figure