A kpc-scale X-ray jet in the BL Lac source S5 2007+777

X-ray jets in AGN are commonly observed in FRII and FRI radio-galaxies, but rarely in BL Lacs, most probably due to their orientation close to the line of sight and the ensuing foreshortening effects. Only three BL Lacs are known so far to contain a kpc-scale X-ray jet. In this paper, we present the evidence for the existence of a fourth extended X-ray jet in the classical radio-selected source S5 2007+777, which for its hybrid FRI/II radio morphology has been classified as a HYMOR (HYbrid MOrphology Radio source). Our Chandra ACIS-S observations of this source revealed an X-ray counterpart to the 19"-long radio jet. Interestingly, the X-ray properties of the kpc-scale jet in S5 2007+777 are very similar to those observed in FRII jets. First, the X-ray morphology closely mirrors the radio one, with the X-rays being concentrated in the discrete radio knots. Second, the X-ray continuum of the jet/brightest knot is described by a very hard power law, with photon index Gamma_x~1, although the uncertainties are large. Third, the optical upper limit from archival HST data implies a concave radio-to-X-ray SED. If the X-ray emission is attributed to IC/CMB with equipartition, strong beaming (delta=13) is required, implying a very large scale (Mpc) jet. The beaming requirement can be somewhat relaxed assuming a magnetic field lower than equipartition. Alternatively, synchrotron emission from a second population of very high-energy electrons is viable. Comparison to other HYMOR jets detected with Chandra is discussed, as well as general implications for the origin of the FRI/II division.Comment: Accepted for publication in ApJ, 19 pages, 3 figure

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods: By using murine models consisting in the injection of colon 26 murine adenocarcinoma (C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager−/− (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager−/− mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell- or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager−/− mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results: We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions: RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome

On the Existence of Energy-Preserving Symplectic Integrators Based upon Gauss Collocation Formulae

We introduce a new family of symplectic integrators depending on a real parameter. When the paramer is zero, the corresponding method in the family becomes the classical Gauss collocation formula of order 2s, where s denotes the number of the internal stages. For any given non-null value of the parameter, the corresponding method remains symplectic and has order 2s-2: hence it may be interpreted as an order 2s-2 (symplectic) perturbation of the Gauss method. Under suitable assumptions, we show that the free parameter may be properly tuned, at each step of the integration procedure, so as to guarantee energy conservation in the numerical solution. The resulting symplectic, energy conserving method shares the same order 2s as the generating Gauss formula.Comment: 19 pages, 7 figures; Sections 1, 2, and 6 sliglthly modifie

Limitations of Radar Coordinates

The construction of a radar coordinate system about the world line of an observer is discussed. Radar coordinates for a hyperbolic observer as well as a uniformly rotating observer are described in detail. The utility of the notion of radar distance and the admissibility of radar coordinates are investigated. Our results provide a critical assessment of the physical significance of radar coordinates.Comment: 12 pages, revtex and pictex macros, 3 pictex figures, 1 eps figure. Expanded versio

Ordinary and Extraordinary Hadrons

Resonances and enhancements in meson-meson scattering can be divided into two classes distinguished by their behavior as the number of colors N_c in QCD becomes large: The first are ordinary mesons that become stable as N_c goes to infinity. This class includes textbook q-bar q mesons as well as glueballs and hybrids. The second class, extraordinary mesons, are enhancements that disappear as N_c goes to infinity; they subside into the hadronic continuum. This class includes indistinct and controversial objects that have been classified as q-bar q-bar q q mesons or meson-meson molecules. Pelaez's study of the N_c dependence of unitarized chiral dynamics illustrates both classes: the p-wave pi-pi and K-pi resonances, the rho(770) and K*(892), behave as ordinary mesons; the s-wave pi-pi and K-pi enhancements, the sigma(600) and kappa(800), behave like extraordinary mesons. Ordinary mesons resemble Feshbach resonances while extraordinary mesons look more like effects due to potentials in meson-meson scattering channels. I build and explore toy models along these lines. Finally I discuss some related dynamical issues affecting the interpretation of extraordinary mesons.Comment: 18 pages, 10 figures, talk presented at the 2006 Yukawa International Seminar: New Frontiers in QCD, Kyoto University, November 2006. This talk is dedicated to the memory of R. H. Dalit