Seismic source functions and attenuation from local and teleseismic observations of the NTS events Jorum and Handley

Several strong-motion seismograms recorded at 8 km from a large nuclear test at Pahute Mesa, Nevada Test Site, are modeled using the Cagniard-de Hoop technique. The ratio of vertical to radial motions suggest that the peak values are produced by ray paths that penetrated to a depth several kilometers below the source. A homogeneous layered Earth model with velocity increasing with depth was used in the modeling of the velocity time histories. The upper portion of the velocity model was determined by averaging bore-hole data and the lower portion was obtained from regional refraction measurements. Assuming a modified Haskell (1967) source representation, ψ(t) = ψ_o[1 - e^(-Kt)(1 + Kt (Kt)^2/2 - B(Kt)^3)] we obtain a range of source descriptions with ψ_o varying with K and B, ψ_o (K,B). The range of source models for Jorum are ψ_o (5, 1) = 3.1, ψ_o (5, 2) = 1.7, and ψ_o (5, 3) = 1.2 times 10^(11) cm^3, respectively. Given an explosion source description, it is a straightforward task to determine the teleseismic attenuation from WWSSN observations. From both the short- and long-period observations from these events, an average t^* of 1.3 is obtained for compressional waves of a dominant 1-sec period. This estimate is insensitive to the range of K and B obtained from the near-field modeling

Simulation of strong ground motions

The estimation of potential strong ground motions at short epicentral distances (Δ = 10 to 25 km) resulting from large earthquakes, M ≧ 6.5, generally requires extrapolation of a limited data set. The goal of this project has been to quantify the extrapolation through a simulation technique that relies heavily upon the more extensive data set from smaller magnitude earthquakes. The simulation utilizes the smaller events as Green's functions for the elements of a larger fault. Comparison of the simulated peak acceleration and duration with the data from the Parkfield earthquake is very good. Simulation of three earthquakes, M = 5.5, 6.5, and 7.0 indicate that the slope of the peak acceleration versus distance curve (Δ = 5 to 25 km) flattens, for strike-slip earthquakes, as the magnitude increases

Peak acceleration scaling studies

An acceleration time history can be decomposed into a series of operations that transfers energy from each point on the fault to the recording station ACC(t) = S * R * E * Q where S is the source time function, R represents rupture over a finite fault, E is the elastic propagation through the earth, and Q is the path attenuation, assumed to be linear. If these operators were exactly known, a deterministic approach to predicting strong ground motions would be straightforward. For the current study, E was computed from a velocity model that incorporates a stiff sedimentary layer over a southern California crust. A range of realistic rupture velocities have been obtained by other investigators and is incorporated into the simulation. Assumptions of the path averaged attenuation, Q, can be tested by comparing with observational data, as a function of distance, the parameters peak acceleration, and computed M_L. This provides a check on both the high frequency (∼ 5 Hz) and long-period (∼ 1 sec) behavior of E^* Q. An average curstal shear wave Q_β of 300 is found to be compatible with observational data (M_L = 4.5 to 5.0). Assumptions of S can be avoided by using real sources derived from accelerograms recorded at small epicentral distances (epicentral distance/source depth < 1). Using these operators, accelerograms have been simulated for strike-slip faulting for four magnitudes: 4.5; 5.5; 6.5; and 7.0. The shapes of the derived average peak ground acceleration (PGA) versus distance curves are well described by the simple equation PGA α [R + C(M)]^(−1.75), where R is the closest distance to the fault surface and C(4.5) = 6, C(5.5) = 12, C(6.5) = 22, and C(7.0) = 36 km

Medical genetics and genomic medicine in the United States. Part 2: Reproductive genetics, newborn screening, genetic counseling, training, and registries

eview of genetics in the United States with emphasis on the prenatal, metabolic, genetic counseling, and training aspects of the field

Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans

Preclinical studies demonstrate that pro-inflammatory cytokines increase serotonin transporter availability and function, leading to depressive symptoms in rodent models. Herein we investigate associations between circulating inflammatory markers and brainstem serotonin transporter (5-HTT) availability in humans. We hypothesised that higher circulating inflammatory cytokine concentrations, particularly of tumour necrosis factor (TNF-α), would be associated with greater 5-HTT availability, and that TNF-α inhibition with etanercept (sTNFR:Fc) would in turn reduce 5-HTT availability. In 13 neurologically healthy adult women, plasma TNF-α correlated significantly with 5-HTT availability (rho=0.6; p=0.03) determined by [123I] -beta-CIT SPECT scanning. This association was replicated in an independent sample of 12 patients with psoriasis/psoriatic arthritis (rho=0.76; p=0.003). Indirect effects analysis, showed that there was a significant overlap in the variance explained by 5-HTT availability and TNF-α concentrations on BDI scores. Treatment with etanercept for 6-8 weeks was associated with a significant reduction in 5-HTT availability (Z= 2.09; p=0.03; r=0.6) consistent with a functional link. Our findings confirm an association between TNF-α and 5-HTT in both the basal physiological and pathological condition. Modulation of both TNF-α and 5-HTT by etanercept indicate the presence of a mechanistic pathway whereby circulating inflammatory cytokines are related to central nervous system substrates underlying major depression

Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra

We describe a novel magnetic resonance imaging technique for detecting metabolism indirectly through changes in oxyhemoglobin:deoxyhemoglobin ratios and T2* signal change during ‘oxygen challenge’ (OC, 5 mins 100% O2). During OC, T2* increase reflects O2 binding to deoxyhemoglobin, which is formed when metabolizing tissues take up oxygen. Here OC has been applied to identify tissue metabolism within the ischemic brain. Permanent middle cerebral artery occlusion was induced in rats. In series 1 scanning (n=5), diffusion-weighted imaging (DWI) was performed, followed by echo-planar T2* acquired during OC and perfusion-weighted imaging (PWI, arterial spin labeling). Oxygen challenge induced a T2* signal increase of 1.8%, 3.7%, and 0.24% in the contralateral cortex, ipsilateral cortex within the PWI/DWI mismatch zone, and ischemic core, respectively. T2* and apparent diffusion coefficient (ADC) map coregistration revealed that the T2* signal increase extended into the ADC lesion (3.4%). In series 2 (n=5), FLASH T2* and ADC maps coregistered with histology revealed a T2* signal increase of 4.9% in the histologically defined border zone (55% normal neuronal morphology, located within the ADC lesion boundary) compared with a 0.7% increase in the cortical ischemic core (92% neuronal ischemic cell change, core ADC lesion). Oxygen challenge has potential clinical utility and, by distinguishing metabolically active and inactive tissues within hypoperfused regions, could provide a more precise assessment of penumbra

A longitudinal study of closed head injury : neuropsychological outcome and structural analysis using region of interest measurements and voxel-based morphometry

Background: The hippocampus and corpus callosum have been shown to be vulnerable in head injury. Various neuroimaging modalities and quantitative measurement techniques have been employed to investigate pathological changes in these structures. Cognitive and behavioural deficiencies have also been well documented in head injury. Aims: The aim of this research project was to investigate structural changes in the hippocampus and corpus callosum. Two different quantitative methods were used to measure physical changes and neuropsychological assessment was performed to determine cognitive and behavioural deficit. It was also intended to investigate the relationship between structural change and neuropsychology at 1 and 6 months post injury. Method: Forty-seven patients with head injury (ranging from mild to severe) had undergone a battery of neuropsychological tests and an MRI scan at 1 and 6 months post injury. T1-weighted MRI scans were obtained and analysis of hippocampus and corpus callosum was performed using region-of-interest techniques and voxel-based morphometry which also included comparison to 18 healthy volunteers. The patients completed neuropsychological assessment at 1 and 6 months post injury and data obtained was analysed with respect to each assessment and with structural data to determine cognitive decline and correlation with neuroanatomy. Results: Voxel-based morphometry illustrated reduced whole scan signal differences between patients and controls and changes in patients between 1 and 6 months post injury. Reduced grey matter concentration was also found using voxel-based morphometry and segmented images between patients and controls. A number of neuropsychological aspects were related to injury severity and correlations with neuroanatomy were present. Voxel-based morphometry provided a greater number of associations than region-of-interest analysis. No longitudinal changes were found in the hippocampus or corpus callosum using region-of-interest methodology or voxel-based morphometry. Conclusions: Decreased grey matter concentration identified with voxel-based morphometry illustrated that structural deficit was present in the head injured patients and does not change between 1 and 6 months. Voxel-based morphometry appears more sensitive for detecting structural changes after head injury than region- of-interest methods. Although the majority of patients had suffered mild head injury, cognitive and neurobehavioural deficits were evidenced by a substantial number of patients reporting increased anxiety and depression levels. Also, the findings of relationships between reduced grey matter concentration and cognitive test scores are indicative of the effects of diffuse brain damage in the patient group.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

A longitudinal study of closed head injury : neuropsychological outcome and structural analysis using region of interest measurements and voxel-based morphometry

Background: The hippocampus and corpus callosum have been shown to be vulnerable in head injury. Various neuroimaging modalities and quantitative measurement techniques have been employed to investigate pathological changes in these structures. Cognitive and behavioural deficiencies have also been well documented in head injury. Aims: The aim of this research project was to investigate structural changes in the hippocampus and corpus callosum. Two different quantitative methods were used to measure physical changes and neuropsychological assessment was performed to determine cognitive and behavioural deficit. It was also intended to investigate the relationship between structural change and neuropsychology at 1 and 6 months post injury. Method: Forty-seven patients with head injury (ranging from mild to severe) had undergone a battery of neuropsychological tests and an MRI scan at 1 and 6 months post injury. T1-weighted MRI scans were obtained and analysis of hippocampus and corpus callosum was performed using region-of-interest techniques and voxel-based morphometry which also included comparison to 18 healthy volunteers. The patients completed neuropsychological assessment at 1 and 6 months post injury and data obtained was analysed with respect to each assessment and with structural data to determine cognitive decline and correlation with neuroanatomy. Results: Voxel-based morphometry illustrated reduced whole scan signal differences between patients and controls and changes in patients between 1 and 6 months post injury. Reduced grey matter concentration was also found using voxel-based morphometry and segmented images between patients and controls. A number of neuropsychological aspects were related to injury severity and correlations with neuroanatomy were present. Voxel-based morphometry provided a greater number of associations than region-of-interest analysis. No longitudinal changes were found in the hippocampus or corpus callosum using region-of-interest methodology or voxel-based morphometry. Conclusions: Decreased grey matter concentration identified with voxel-based morphometry illustrated that structural deficit was present in the head injured patients and does not change between 1 and 6 months. Voxel-based morphometry appears more sensitive for detecting structural changes after head injury than region- of-interest methods. Although the majority of patients had suffered mild head injury, cognitive and neurobehavioural deficits were evidenced by a substantial number of patients reporting increased anxiety and depression levels. Also, the findings of relationships between reduced grey matter concentration and cognitive test scores are indicative of the effects of diffuse brain damage in the patient group.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The Ursinus Weekly, October 24, 1974

Profs to lecture on Pa. Dutch arts • Dr. Lodge joins U.C. Psych Dept. • Campus Chest plans for funds and fun • Forum features flute and guitar • Is there a ghost in U.C.\u27s haunted hall? • Letters to the editor: Students demand a good education • The origin of The Lantern • Alumni corner • An autumn walk • Mr. Richter goes to school • What\u27s playing at the movies? • Spectrum blues: Joe Cocker • Spanish Club plans outing • Campus Gold activities • Introducing campus leaders • Money given away • Ursinus Homecoming 1974: Fraternity candidates to wear the queen\u27s crown • Homecoming from Ursinus past • Union ripped-off • A football commentary • X-country: three in a rowhttps://digitalcommons.ursinus.edu/weekly/1023/thumbnail.jp

Screening Analysis for EPACT-Covered Commercial HVAC and Water-Heating Equipment

The Energy Policy and Conservation Act (EPCA) as amended by the Energy Policy Act of 1992 (EPACT) establishes that the U.S. Department of Energy (DOE) regulate efficiency levels of certain categories of commercial heating, cooling, and water-heating equipment. EPACT establishes the initial minimum efficiency levels for products falling under these categories, based on ASHRAE/IES Standard 90.1-1989 requirements. EPCA states that, if ASHRAE amends Standard 90.1-1989 efficiency levels, then DOE must establish an amended uniform national manufacturing standard at the minimum level specified in the amended Standard 90.1 and that it can establish higher efficiency levels if they would result in significant additional energy savings. 011Standard 90.1-1999 increases minimum efficiency levels for some of the equipment categories covered by EPCA 92. DOE conducted a screening analysis to determine the energy-savings potential for EPACT-covered products meet and exceeding these levels. This paper describes the methodology, data assumptions, and results of the analysis