Direct observation of domain wall structures in curved permalloy wires containing an antinotch

The formation and field response of head-to-head domain walls in curved permalloy wires, fabricated to contain a single antinotch, have been investigated using Lorentz microscopy. High spatial resolution maps of the vector induction distribution in domain walls close to the antinotch have been derived and compared with micromagnetic simulations. In wires of 10 nm thickness the walls are typically of a modified asymmetric transverse wall type. Their response to applied fields tangential to the wire at the antinotch location was studied. The way the wall structure changes depends on whether the field moves the wall away from or further into the notch. Higher fields are needed and much more distorted wall structures are observed in the latter case, indicating that the antinotch acts as an energy barrier for the domain wal

A New Approximate Min-Max Theorem with Applications in Cryptography

We propose a novel proof technique that can be applied to attack a broad class of problems in computational complexity, when switching the order of universal and existential quantifiers is helpful. Our approach combines the standard min-max theorem and convex approximation techniques, offering quantitative improvements over the standard way of using min-max theorems as well as more concise and elegant proofs

Simulating the oxygen content of ambient organic aerosol with the 2D volatility basis set

A module predicting the oxidation state of organic aerosol (OA) has been developed using the two-dimensional volatility basis set (2D-VBS) framework. This model is an extension of the 1D-VBS framework and tracks saturation concentration and oxygen content of organic species during their atmospheric lifetime. The host model, a one-dimensional Lagrangian transport model, is used to simulate air parcels arriving at Finokalia, Greece during the Finokalia Aerosol Measurement Experiment in May 2008 (FAME-08). Extensive observations were collected during this campaign using an aerosol mass spectrometer (AMS) and a thermodenuder to determine the chemical composition and volatility, respectively, of the ambient OA. Although there are several uncertain model parameters, the consistently high oxygen content of OA measured during FAME-08 (O:C = 0.8) can help constrain these parameters and elucidate OA formation and aging processes that are necessary for achieving the high degree of oxygenation observed. The base-case model reproduces observed OA mass concentrations (measured mean = 3.1 μg m<sup>−3</sup>, predicted mean = 3.3 μg m<sup>−3</sup>) and O:C (predicted O:C = 0.78) accurately. A suite of sensitivity studies explore uncertainties due to (1) the anthropogenic secondary OA (SOA) aging rate constant, (2) assumed enthalpies of vaporization, (3) the volatility change and number of oxygen atoms added for each generation of aging, (4) heterogeneous chemistry, (5) the oxidation state of the first generation of compounds formed from SOA precursor oxidation, and (6) biogenic SOA aging. Perturbations in most of these parameters do impact the ability of the model to predict O:C well throughout the simulation period. By comparing measurements of the O:C from FAME-08, several sensitivity cases including a high oxygenation case, a low oxygenation case, and biogenic SOA aging case are found to unreasonably depict OA aging, keeping in mind that this study does not consider possibly important processes like fragmentation that may offset mass gains and affect the prediction bias. On the other hand, many of the cases chosen for this study predict average O:C estimates that are consistent with the observations, illustrating the need for more thorough experimental characterizations of OA parameters including the enthalpy of vaporization and oxidation state of the first generation of SOA products. The ability of the model to predict OA concentrations is less sensitive to perturbations in the model parameters than its ability to predict O:C. In this sense, quantifying O:C with a predictive model and constraining it with AMS measurements can reduce uncertainty in our understanding of OA formation and aging

Two Clusters with Radio-quiet Cooling Cores

Radio lobes inflated by active galactic nuclei at the centers of clusters are a promising candidate for halting condensation in clusters with short central cooling times because they are common in such clusters. In order to test the AGN-heating hypothesis, we obtained Chandra observations of two clusters with short central cooling times yet no evidence for AGN activity: Abell 1650 and Abell 2244. The cores of these clusters indeed appear systematically different from cores with more prominent radio emission. They do not have significant central temperature gradients, and their central entropy levels are markedly higher than in clusters with stronger radio emission, corresponding to central cooling times ~ 1 Gigayear. Also, there is no evidence for fossil X-ray cavities produced by an earlier episode of AGN heating. We suggest that either (1) the central gas has not yet cooled to the point at which feedback is necessary to prevent it from condensing, possibly because it is conductively stabilized, or (2) the gas experienced a major heating event $\gtrsim 1$ Gyr in the past and has not required feedback since then. The fact that these clusters with no evident feedback have higher central entropy and therefore longer central cooling times than clusters with obvious AGN feedback strongly suggests that AGNs supply the feedback necessary to suppress condensation in clusters with short central cooling times.Comment: ApJ Letter, in pres

Life Satisfaction and Perceived Meaningfulness of Learning Experience among First-Year Traditional Graduate Social Work Students

Knowledge about life satisfaction and learning experience among first-year graduate students is sparse, despite its relevance to instructional decisions, academic support, and success of students. Adequate knowledge is crucial, as it may help graduate students manage personal and professional life changes associated with graduate education. Using a convenience sample of 118 first-year traditional social work graduate students in a northeastern U.S. university the study examined associations of life satisfaction and peer support with perception of meaningfulness of learning experience, as well as associations of gender, marital status, family support and perceived stress with life satisfaction. Results suggest that receiving higher peer support was associated with perceived meaningfulness of learning experience, whereas being female, being married, having lower perceived stress, and receiving higher family support were associated with life satisfaction. Reciprocal predictive relationship between life satisfaction and perceived meaningfulness of learning experience was found. In general, findings suggest that stress and support are important variables to consider in understanding life satisfaction and learning experience of first-year traditional social work graduate students and highlight the importance of peer and family support to navigating challenges of graduate education. Most importantly, findings have implications for social work education, highlighting how instructor’s utilization of instructional approaches that facilitate peer support may help ease transition into graduate education or help prevent drop out during the first year graduate students are most vulnerable to dropping out. Altogether, findings highlight why exploring perceived meaningfulness of learning experience and life satisfaction is crucial for identifying supportive needs of graduate students. Keywords: Life satisfaction; learning experience; perceived stress; family support; peer support

Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma

Multiple genetic alterations are well recognized as contributing to pancreatic carcinogenesis, although the finding of recurrent copy number changes indicates additional targets remain to be found. The objective of this study was to identify novel targets of genetic alteration that contribute to pancreatic cancer development or progression. We used Representational Oligonucleotide Microarray Analysis (ROMA) to identify copy number changes in pancreatic cancer xenografts, and validated these findings using FISH, quantitative PCR, Western blotting and immunohistochemical labeling. With this approach, we identified a 0.36-Mb amplification at 18q11.2 containing two known genes, GATA-6 and cTAGE1. Using a cutoff value of 3.0 fold compared to haploid controls, copy number gain or amplification was confirmed in 4 of 42 (9.5%) pancreatic carcinomas analyzed. Combined genetic and transcriptional analyses showed consistent overexpression of GATA-6 in all carcinomas with 18q11.2 gain, as well as in the majority of pancreatic cancers examined (17 of 30 cancers, 56.7%) that did not have gain of this region. By contrast, overexpression of cTAGE1 was rare in these same cancers suggesting GATA-6 is the true target of this copy number increase. GATA-6 mRNA overexpression corresponded to robust nuclear protein expression in cancer cell lines and resected tissues consistent with its role as a transcription factor. Intense nuclear labeling was significantly increased in PanIN-3 lesions and infiltrating carcinomas compared to normal duct epithelium (p < 0.000001 and p < 0.003, respectively). Forced overexpression of GATA6 in MiaPaca2 cells resulted in increased proliferation and growth in soft-agar. Gain and overexpression of the development-related transcription factor GATA-6 may play an important and hitherto unrecognized role in pancreatic carcinogenesis

Brightest Cluster Galaxies and Core Gas Density in REXCESS Clusters

We investigate the relationship between brightest cluster galaxies (BCGs) and their host clusters using a sample of nearby galaxy clusters from the Representative XMM Cluster Structure Survey (REXCESS). The sample was imaged with the Southern Observatory for Astrophysical Research (SOAR) in R band to investigate the mass of the old stellar population. Using a metric radius of 12h^-1 kpc, we found that the BCG luminosity depends weakly on overall cluster mass as L_BCG \propto M_cl^0.18+-0.07, consistent with previous work. We found that 90% of the BCGs are located within 0.035 r_500 of the peak of the X-ray emission, including all of the cool core (CC) clusters. We also found an unexpected correlation between the BCG metric luminosity and the core gas density for non-cool core (non-CC) clusters, following a power law of n_e \propto L_BCG^2.7+-0.4 (where n_e is measured at 0.008 r_500). The correlation is not easily explained by star formation (which is weak in non-CC clusters) or overall cluster mass (which is not correlated with core gas density). The trend persists even when the BCG is not located near the peak of the X-ray emission, so proximity is not necessary. We suggest that, for non-CC clusters, this correlation implies that the same process that sets the central entropy of the cluster gas also determines the central stellar density of the BCG, and that this underlying physical process is likely to be mergers.Comment: 16 pages, 8 figures, accepted Astrophysical Journa

Star Formation, Radio Sources, Cooling X-ray Gas, and Galaxy Interactions in the Brightest Cluster Galaxy in 2A0335+096

We present deep emission-line imaging taken with the SOAR Optical Imaging Camera of the brightest cluster galaxy (BCG) in the nearby (z=0.035) X-ray cluster 2A0335+096. We analyze long-slit optical spectroscopy, archival VLA, Chandra X-ray, and XMM UV data. 2A0335+096 is a bright, cool-core X-ray cluster, once known as a cooling flow. Within the highly disturbed core revealed by Chandra X-ray observations, 2A0335+096 hosts a highly structured optical emission-line system. The redshift of the companion is within 100 km/s of the BCG and has certainly interacted with the BCG, and is likely bound to it. The comparison of optical and radio images shows curved filaments in H-alpha emission surrounding the resolved radio source. The velocity structure of the emission-line bar between the BCG nucleus and the companion galaxy provides strong evidence for an interaction between the two in the last ~50 Myrs. The age of the radio source is similar to the interaction time, so this interaction may have provoked an episode of radio activity. We estimate a star formation rate of >7 solar mass/yr based on the Halpha and archival UV data, a rate similar to, but somewhat lower than, the revised X-ray cooling rate of 10-30 solar masses/year estimated from XMM spectra by Peterson & workers. The Halpha nebula is limited to a region of high X-ray surface brightness and cool X-ray temperature. The detailed structures of H-alpha and X-ray gas differ. The peak of the X-ray emission is not the peak of H-alpha emission, nor does it lie in the BCG. The estimated age of the radio lobes and their interaction with the optical emission-line gas, the estimated timescale for depletion and accumulation of cold gas, and the dynamical time in the system are all similar, suggesting a common trigger mechanism.Comment: Accepted AJ, July 2007 publication. Vol 134, p. 14-2

Cooling in the X-ray halo of the rotating, massive early-type galaxy NGC 7049

The relative importance of the physical processes shaping the thermodynamics of the hot gas permeating rotating, massive early-type galaxies is expected to be different from that in non-rotating systems. Here, we report the results of the analysis of XMM-Newton data for the massive, lenticular galaxy NGC 7049. The galaxy harbours a dusty disc of cool gas and is surrounded by an extended hot X-ray emitting gaseous atmosphere with unusually high central entropy. The hot gas in the plane of rotation of the cool dusty disc has a multi-temperature structure, consistent with ongoing cooling. We conclude that the rotational support of the hot gas is likely capable of altering the multiphase condensation regardless of the $t_{\rm cool}/t_{\rm ff}$ ratio, which is here relatively high, $\sim 40$. However, the measured ratio of cooling time and eddy turnover time around unity ($C$-ratio $\approx 1$) implies significant condensation, and at the same time, the constrained ratio of rotational velocity and the velocity dispersion (turbulent Taylor number) ${\rm Ta_t} > 1$ indicates that the condensing gas should follow non-radial orbits forming a disc instead of filaments. This is in agreement with hydrodynamical simulations of massive rotating galaxies predicting a similarly extended multiphase disc.Comment: 11 pages, 12 figures, accepted for publication in MNRA