533 research outputs found
The BioGRID Interaction Database: 2011 update
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein
interaction data from model organisms and humans
(http://www.thebiogrid.org). BioGRID currently holds 347 966
interactions (170 162 genetic, 177 804 protein) curated from both
high-throughput data sets and individual focused studies, as derived
from over 23 000 publications in the primary literature. Complete
coverage of the entire literature is maintained for budding yeast
(Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe)
and thale cress (Arabidopsis thaliana), and efforts to expand curation
across multiple metazoan species are underway. The BioGRID houses 48
831 human protein interactions that have been curated from 10 247
publications. Current curation drives are focused on particular areas
of biology to enable insights into conserved networks and pathways that
are relevant to human health. The BioGRID 3.0 web interface contains
new search and display features that enable rapid queries across
multiple data types and sources. An automated Interaction Management
System (IMS) is used to prioritize, coordinate and track curation
across international sites and projects. BioGRID provides interaction
data to several model organism databases, resources such as Entrez-Gene
and other interaction meta-databases. The entire BioGRID 3.0 data
collection may be downloaded in multiple file formats, including PSI MI
XML. Source code for BioGRID 3.0 is freely available without any
restrictions
Double-beta decay of Te to the first 0 excited state of Xe with CUORICINO
The CUORICINO experiment was an array of 62 TeO single-crystal
bolometers with a total Te mass of kg. The experiment finished
in 2008 after more than 3 years of active operating time. Searches for both
and double-beta decay to the first excited state in
Xe were performed by studying different coincidence scenarios. The
analysis was based on data representing a total exposure of
N(Te)t=y. No evidence for a signal was
found. The resulting lower limits on the half lives are y (90% C.L.), and
y (90%
C.L.).Comment: 6 pages, 4 figure
A simple radionuclide-driven single-ion source
We describe a source capable of producing single barium ions through nuclear
recoils in radioactive decay. The source is fabricated by electroplating 148Gd
onto a silicon {\alpha}-particle detector and vapor depositing a layer of BaF2
over it. 144Sm recoils from the alpha decay of 148Gd are used to dislodge Ba+
ions from the BaF2 layer and emit them in the surrounding environment. The
simultaneous detection of an {\alpha} particle in the substrate detector allows
for tagging of the nuclear decay and of the Ba+ emission. The source is simple,
durable, and can be manipulated and used in different environments. We discuss
the fabrication process, which can be easily adapted to emit most other
chemical species, and the performance of the source
Prevalence of filarioid nematodes and trypanosomes in American robins and house sparrows, Chicago USA
AbstractHosts are commonly infected with a suite of parasites, and interactions among these parasites can affect the size, structure, and behavior of host–parasite communities. As an important step to understanding the significance of co-circulating parasites, we describe prevalence of co-circulating hemoparasites in two important avian amplification hosts for West Nile virus (WNV), the American robin (Turdus migratorius) and house sparrow (Passer domesticus), during the 2010–2011 in Chicago, Illinois, USA. Rates of nematode microfilariemia were 1.5% of the robins (n=70) and 4.2% of the house sparrows (n=72) collected during the day and 11.1% of the roosting robins (n=63) and 0% of the house sparrows (n=11) collected at night. Phylogenetic analysis of nucleotide sequences of the 18S rRNA and cytochrome oxidase subunit I (COI) genes from these parasites resolved two clades of filarioid nematodes. Microscopy revealed that 18.0% of American robins (n=133) and 16.9% of house sparrows (n=83) hosted trypanosomes in the blood. Phylogenetic analysis of nucleotide sequences from the 18s rRNA gene revealed that the trypanosomes fall within previously described avian trypanosome clades. These results document hemoparasites in the blood of WNV hosts in a center of endemic WNV transmission, suggesting a potential for direct or indirect interactions with the virus
Search for Neutrinoless Double-Beta Decay in Xe with EXO-200
We report on a search for neutrinoless double-beta decay of Xe with
EXO-200. No signal is observed for an exposure of 32.5 kg-yr, with a background
of ~1.5 x 10^{-3} /(kg yr keV) in the region of interest. This
sets a lower limit on the half-life of the neutrinoless double-beta decay
(Xe) > 1.6 x 10 yr (90% CL),
corresponding to effective Majorana masses of less than 140-380 meV, depending
on the matrix element calculation
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