鉛直下向き揚力を発生する没水翼の造波現象に関する研究

研究期間:平成6-7年度 ; 研究種目:一般研究B ; 課題番号: 0645235

Predicting the Motions of a Fishing Boat Caused by Improving the Stern Part using a Hybrid Particle-Grid Scheme

Improving a ship’s stern part could help to reduce greenhouse gases and costs. However, a ship sailing in actual conditions experiences disturbances that can affect its performance. Ship performance is an important aspect of the design process that guarantees ship safety. The heave and pitch motions of an improved fishing boat were predicted numerically by using a hybrid scheme of Eulerian grid-Lagrangian particle, hereinafter improving its stern part and attaching an additional part. The stern part improvement and additional structure attachment affected an increase on the heave amplitude from the ship’s basic form by 5% to 10%. Moreover, the improvement of the stern part in the bottom area contributed to a better heave amplitude than that of the side area. Finally, the pitch amplitude for all forms was relatively small and affected an increase of 5% to 9%, dependent on the form. The improvement had a greater effect on heave motion than pitch

High Human T Cell Leukemia Virus Type-1(HTLV-1) Provirus Load in Patients with HTLV-1 Carriers Complicated with HTLV-1-unrelated disorders

<p>Abstract</p> <p>Background</p> <p>To address the clinical and virological significance of a high HTLV-1 proviral load (VL) in practical blood samples from asymptomatic and symptomatic carriers, we simultaneously examined VL and clonal expansion status using polymerase chain reaction (PCR) quantification (infected cell % of peripheral mononuclear cells) and Southern blotting hybridization (SBH) methods.</p> <p>Results</p> <p>The present study disclosed extremely high VL with highly dense smears with or without oligoclonal bands in SBH. A high VL of 10% or more was observed in 16 (43.2%) of a total of 33 samples (one of 13 asymptomatic carriers, 8 of 12 symptomatic carriers, and 7 of 8 patients with lymphoma-type ATL without circulating ATL cells). In particular, an extremely high VL of 50% or more was limited to symptomatic carriers whose band findings always contained at least dense smears derived from polyclonally expanded cells infected with HTLV-1. Sequential samples revealed that the VL value was synchronized with the presence or absence of dense smears, and declined at the same time as disappearing dense smears. Dense smears transiently emerged at the active stage of the underlying disease. After disappearance of the smears, several clonal bands became visible and were persistently retained, explaining the process by which the clonality of HTLV-1-infected cells is established. The cases with only oligoclonal bands tended to maintain a stable VL of around 20% for a long time. Two of such cases developed ATL 4 and 3.5 years later, suggesting that a high VL with oligoclonal bands may be a predisposing risk to ATL.</p> <p>Conclusion</p> <p>The main contributor to extremely high VL seems to be transient emergence of dense smears detected by the sensitivity level of SBH, corresponding to polyclonal expansion of HTLV-1-infected cells including abundant small clones. Major clones retained after disappearance of dense smears stably persist and acquire various malignant characteristics step by step.</p

Effects of Microgravity on Cerebral Hemodynamics

After centuries of wonder, human being finally realized the decisive possibility of going to the moon a little more than 50 years ago, and in 1969 this became a reality, no longer a dream. The human body, however, is designed to live under 1 g as on Earth. Thus, it is important to understand what happens in the human body under microgravity in order to make rapid progress in space development. One of the most serious problems produced by microgravity is a fluid shift from lower to upper body. This cephalad fluid shift may change the hemodynamics in the brain. In this review, effects of actual or simulated microgravity on cerebral blood flow, intracranial pressure, formation of brain edema, and orthostatic intolerance will be discussed. These studies provide us lots of information not only to maintain the health of astronauts but also to treat senile persons who, on rare occasions, sit or stand up

Experimental apparatus at KUR-ISOL to identify isomeric transitions from fission products, and decay spectroscopy of 151Ce

Decay studies on 151Ce have been performed using the on-line isotope separator connected to the Kyoto University Reactor. In addition to conventional γ and conversion electron spectroscopy, β-gated measurements were carried out on mass-separated 151Ce to identify an isomeric transition. From the analysis of the obtained data, the half-life of the isotope was ascertained to be 1.76(6) s and a decay scheme containing six excited levels was constructed for the first time. The excited level at 35.1 keV in 151Pr was found to be a long-lived state (a half-life of approximately 10us or longer)

High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.

For relevant imatinib therapy against Philadelphia (Ph)-positive leukemias, it is essential to monitor mutations in the chimerical bcr-abl tyrosine kinase domain (TKD). However, there is no universally acceptable consensus on how to efficiently identify mutations in the target TKD. Recently, high-resolution melting (HRM) technology was developed, which allows gene scanning using an inexpensive generic heteroduplex-detecting dsDNA-binding dye. This study aimed to validate the introduction of HRM in a practical clinical setting for screening of mutations in sporadic sites of the chimerical bcr-abl TKD. All chimerical and wild-type abl TKD regions selectively amplified were used for HRM assays and direct sequencing. The HRM test had approximately 5-90% detection sensitivity for mutations. In contrast to mixture samples with mutant and wild-type cells, all mutant cell samples had indeterminate melting curves equivalent to those of the wild-type due to formation of only a homodulex. This issue was improved by the addition of exogenous wild-type DNA after PCR. Subsequently, HRM results gave a high accordance rate of 97.8% (44/45 samples) compared to the sequencing data. The discordant results in one appear to be due to unsuccessful amplification. Thus, HRM may be considered to be suitable for reliable scanning of mutations in the chimerical abl TKD in a clinical setting

Coupled analysis of unsteady aerodynamics and vehicle motion of a road vehicle in windy conditions

The two-way coupling of full-scale vehicle motion and the surrounding turbulence motion has been realized on a developed unsteady aerodynamic simulator for a road vehicle. A large-eddy simulation (LES) technique has been applied to reproduce the unsteady turbulence motion, and an unstructured finite volume method has been adopted to explain the complicated geometry of a full-scale road vehicle. Three-degree-of-freedom equations of the vehicle's dynamic motion are incorporated into the developed LES code, and the motion is numerically reproduced by coupling the arbitrary Lagrangian Eulerian (ALE) method and Navier-Stokes equations in a non-inertial reference frame. The simulation code is implemented on a massively parallel processor to meet the demands of the large-scale, long-term aerodynamic simulations of full-scale road vehicles. As a typical application of the coupled analysis, an unsteady aerodynamics simulation of a simplified heavy-duty truck in windy conditions is demonstrated, and the effects of the unsteady aerodynamics on the truck's motion are investigated. The obtained results are compared with the results of a conventional quasi-steady analysis, and certain differences in the vehicle path and the yaw angle are identified. The effects of the transitional aerodynamics on variables related to driver's perception are significant. These results clearly indicate the importance of estimating the unsteady aerodynamic forces in a vehicle motion analysis. (C) 2012 Elsevier Ltd. All rights reserved