Disruption to control network function correlates with altered dynamic connectivity in the wider autism spectrum.

Autism is a common developmental condition with a wide, variable range of co-occurring neuropsychiatric symptoms. Contrasting with most extant studies, we explored whole-brain functional organization at multiple levels simultaneously in a large subject group reflecting autism's clinical diversity, and present the first network-based analysis of transient brain states, or dynamic connectivity, in autism. Disruption to inter-network and inter-system connectivity, rather than within individual networks, predominated. We identified coupling disruption in the anterior-posterior default mode axis, and among specific control networks specialized for task start cues and the maintenance of domain-independent task positive status, specifically between the right fronto-parietal and cingulo-opercular networks and default mode network subsystems. These appear to propagate downstream in autism, with significantly dampened subject oscillations between brain states, and dynamic connectivity configuration differences. Our account proposes specific motifs that may provide candidates for neuroimaging biomarkers within heterogeneous clinical populations in this diverse condition

The importance of organisational issues in systems development

Abstract: A survey of senior and influential IT managers explored the related questions of why some senior IT professionals perceive organisational issues to be more important than technical issues, and whether this has a concomitant impact on the treatment of organisational issues. An overall response rate of 63% was achieved from a combined survey of two distinct groups. The results show that there are significant differences in managers’ perceptions about the importance of organisational issues which can, to some extent, be explained in terms of organisational size, and to a lesser extent by the favoured development approach. However, these differences in perception appear to have no identifiable relation to the significant differences in the approaches adopted for treating organisational issues. It is suggested that this is due to the difficulties in treating such issues and further research to resolve these difficulties is proposed

The consideration of organizational issues during the systems development process: an empirical analysis

The lack of consideration of organizational issues in systems development can lead to project failure. A review of the literature and a pre-test survey suggested classifying organizational issues into five categories and examining how these are considered by IT managers. A postal survey with responses from 64 senior IT specialists over a cross section of industry and commerce showed that there is a general awareness of the importance of organizational issues but there was little consensus on how they should be addressed in the development process. These IT managers were consistent in spending most effort on the issues perceived as most important from the list of 14 issue provided, but there was considerable variation in which specific issues they rated most important. In general those organizational issues with a `technical’ aspect were given more prominence than those which are less tangible, but which may be more critical to a system’s success

An investigation of the factors affecting the successful treatment of organisational issues in systems development projects

A review of the relevant literature confirms the importance of treating organisational issues in order to avoid information systems development failures. To investigate how such issues are treated in practice and the factors associated with their successful treatment, a large-scale survey was conducted. A questionnaire was mailed to senior IS executives and over 600 responses were received. A majority of the respondents (60%) perceived that organisational issues were more important than technical issues and a similar proportion reported treating these issues explicitly, although there was noticeable variation in the frequency with which specific types of issues were treated. However, only 50% felt that organisational issues were successfully dealt with in more than 30% of the projects for which they were responsible. This proportion seems to be independent of the type of organisation or the general development approach adopted, but the results also indicate that using an approach to treating organisational issues which is explicit, frequent and covers a wide range of specific issues is associated with higher levels of success. These results suggest that senior IT executives need to go further in ensuring that the treatment of organisational issues is given greater time, resource and level of priority

The impact of inadequacies in the treatment of organizational issues on information systems development projects

It has often been argued that systems’ failure may result from inadequacies in the treatment of organizational issues, but there is little consensus on what is meant by the term inadequate treatment and how it influences systems’ success. To test several theoretically plausible hypotheses, a questionnaire was mailed to senior information system (IS) executives and 344 valid responses were received. The results of a statistical analysis indicate that higher levels of systems’ success are associated with treating a wide range of organizational issues throughout the development process and ensuring that members of the user community are actively involved

Exact Performance of Concatenated Quantum Codes

When a logical qubit is protected using a quantum error-correcting code, the net effect of coding, decoherence (a physical channel acting on qubits in the codeword) and recovery can be represented exactly by an effective channel acting directly on the logical qubit. In this paper we describe a procedure for deriving the map between physical and effective channels that results from a given coding and recovery procedure. We show that the map for a concatenation of codes is given by the composition of the maps for the constituent codes. This perspective leads to an efficient means for calculating the exact performance of quantum codes with arbitrary levels of concatenation. We present explicit results for single-bit Pauli channels. For certain codes under the symmetric depolarizing channel, we use the coding maps to compute exact threshold error probabilities for achievability of perfect fidelity in the infinite concatenation limit.Comment: An expanded presentation of the analytic methods and results from quant-ph/0111003; 13 pages, 6 figure

HyBloc: Localization in Sensor Networks with Adverse Anchor Placement

To determine the geographical positions of sensors, numerous localization algorithms have been proposed in recent years. The positions of sensors are inferred from the connectivity between sensors and a set of nodes called anchors which know their precise locations. We investigate the effect of adverse placement and density of anchors on the accuracies of different algorithms. We develop an algorithm called HyBrid Localization (HyBloc) to provide reliable localization service with a limited number of clustered anchors. HyBloc is distributed in nature with reasonable message overhead. Through simulations, we demonstrate that HyBloc provides more accurate location estimates than some existing distributed algorithms when there are only a few anchors. HyBloc also performs well when anchors are clustered together

Achievements and challenges in developing health leadership in South Africa: the experience of the Oliver Tambo Fellowship Programme 2008-2014.

The Oliver Tambo Fellowship Programme is convened by the School of Public Health and Family Medicine, University of Cape Town, South Africa. It is a health leadership training programme with a post-graduate Diploma at its core, supplemented by management seminars, mentorship and alumni networking. An external evaluation was conducted in 2015 for the period since 2008. This rapid, descriptive study made use of mixed methods-including a document review of existing Programme material (management reports, anonymized alumni's implementation project reports, exit interviews, field interviews and e-mailed questionnaires), a brief e-mailed questionnaire, and 18 semi-structured telephonic interviews conducted by the evaluator with Programme alumni, convenors and senior government line managers. Data were analysed according to indicators and associated criteria developed by the evaluator on the basis of the Programme's objectives, international experience, the nature of the South African health system and the particular philosophy of the Programme. The evaluation found that the Diploma offered a unique contribution. This is because it sought less to convey new technical knowledge, than to empower and galvanize students to become change agents in the complex settings of their workplaces. Reflective practice was an important part of this process. Alumni were able to point to a number of positive changes in their management practice and motivation, translating these into improved performance by their teams and more effective health services. Alumni also helped to build the capacity of their own and other staff, sharing the knowledge and skills they had gained through the Programme, and leading by example. However, the Programme found it difficult to arrange adequate mentorship or peer support for alumni once they returned to their workplaces, pointing to the need for human resource development units in government to become more active in supporting alumni and holding them accountable for improving practice