Assignment of the evidential value of a fingermark general pattern using a Bayesian network

Abstract: When visible on a fingermark, the general pattern maintains its importance in the fingerprint examination procedure, since the difference between the general pattern of a fingermark and a fingerprint is sufficient for exclusion. In the current work, the importance of the general pattern is extended by evaluating the strength of evidence of a match given corresponding general pattern. In current practice (due to the lack of statistical support for the general pattern evidence) the fingerprint examiners assign personal probabilities to the general pattern evidence based on their knowledge and experience, while in this work the probabilities are calculated using a Bayesian Network which is fed by empirical data. 1

Sialyl Lewis X Expression and Lymphatic Microvessel Density in Primary Tumors of Node-negative Colorectal Cancer Patients Predict Disease Recurrence

Up to 30% of curatively resected colorectal cancer patients with tumor-negative lymph nodes, show disease recurrence. We assessed whether these high-risk patients can be identified by examining primary tumors for the following blood and lymphatic vasculature markers: A) sialyl Lewis X (sLeX), vascular endothelial growth factor (VEGF)-C and VEGF-D expression; B) blood and lymphatic microvessel density (BMVD/LMVD); and C) the presence of blood and lymphatic vessel invasion. Thirty-six cases (disease recurrence within 5 years) and 72 controls (no disease recurrence for at least 5 years) were selected in a case-control design. Tumor sections were stained by antibodies CSLEX1 (sLeX), anti-VEGF-C, anti-VEGF-D, anti-CD31 (BMVD) or D2–40 (LMVD) to determine the parameters as mentioned above. A multivariate analysis showed sLeX expression and high LMVD (odds ratio 5.1, 95% confidence interval 1.3–20.0 and odds ratio 3.1, 95% confidence interval 1.0–10.0, respectively) to be independent factors predicting disease recurrence. Expression of sLeX correlated with liver metastases (P = 0.015). A high LMVD was related to regional intra-abdominal or intrapelvic metastases in lymph nodes and distant metastases other than in the liver and lungs such as peritoneum, bones, brain and adrenal glands (P = 0.004). A high BMVD in the invasive front correlated with lung metastases (P = 0.018). We show that high-risk node-negative colorectal cancer patients can be identified by primary tumor assessment for sLeX expression and LMVD. Our results are consistent with the notion that both lymphatic and hematogenous metastasis play a role in colorectal cancer

Could lymphatic mapping and sentinel node biopsy provide oncological providence for local resectional techniques for colon cancer? A review of the literature

<p>Abstract</p> <p>Background</p> <p>Endoscopic resectional techniques for colon cancer are undermined by their inability to determine lymph node status. This limits their application to only those lesions at the most minimal risk of lymphatic dissemination whereas their technical capacity could allow intraluminal or even transluminal address of larger lesions. Sentinel node biopsy may theoretically address this breach although the variability of its reported results for this disease is worrisome.</p> <p>Methods</p> <p>Medline, EMBASE and Cochrane databases were interrogated back to 1999 to identify all publications concerning lymphatic mapping for colon cancer with reference cross-checking for completeness. All reports were examined from the perspective of in vivo technique accuracy selectively in early stage disease (i.e. lesions potentially within the technical capacity of endoscopic resection).</p> <p>Results</p> <p>Fifty-two studies detailing the experiences of 3390 patients were identified. Considerable variation in patient characteristics as well as in surgical and histological quality assurances were however evident among the studies identified. In addition, considerable contamination of the studies by inclusion of rectal cancer without subgroup separation was frequent. Indeed such is the heterogeneity of the publications to date, formal meta-analysis to pool patient cohorts in order to definitively ascertain technique accuracy in those with T1 and/or T2 cancer is not possible. Although lymphatic mapping in early stage neoplasia alone has rarely been specifically studied, those studies that included examination of false negative rates identified high T3/4 patient proportions and larger tumor size as being important confounders. Under selected circumstances however the technique seems to perform sufficiently reliably to allow it prompt consideration of its use to tailor operative extent.</p> <p>Conclusion</p> <p>The specific question of whether sentinel node biopsy can augment the oncological propriety for endoscopic resective techniques (including Natural Orifice Transluminal Endoscopic Surgery [NOTES]) cannot be definitively answered at present. Study heterogeneity may account for the variability evident in the results from different centers. Enhanced capacity (perhaps to the level necessary to consider selective avoidance of en bloc mesenteric resection) by its confinement to only early stage disease is plausible although not proven. Specific study of the technique in early stage tumors is clearly essential before proffering this approach.</p

Supporting discussions about forensic Bayesian networks using argumentation

Bayesian networks (BNs) are powerful tools that are increasingly being used by forensic and legal experts to reason about the uncertain conclusions that can be inferred from the evidence in a case. Although in BN construction it is good practice to document the model itself, the importance of documenting design decisions has received little attention. Such decisions, including the (possibly conflicting) reasons behind them, are important for legal experts to understand and accept probabilistic models of cases. Moreover, when disagreements arise between domain experts involved in the construction of BNs, there are no systematic means to resolve such disagreements. Therefore, we propose an approach that allows domain experts to explicitly express and capture their reasons pro and con modelling decisions using argumentation, and that resolves their disagreements as much as possible. Our approach is based on a case study, in which the argumentation structure of an actual disagreement between two forensic BN experts is analysed

Assignment of the evidential value of a fingermark general pattern using a Bayesian network

When visible on a fingermark, the general pattern maintains its importance in the fingerprint examination procedure, since the difference between the general pattern of a fingermark and a fingerprint is sufficient for exclusion. In the current work, the importance of the general pattern is extended by evaluating the strength of evidence of a match given corresponding general pattern. In current practice (due to the lack of statistical support for the general pattern evidence) the fingerprint examiners assign personal probabilities to the general pattern evidence based on their knowledge and experience, while in this work the probabilities are calculated using a Bayesian Network which is fed by empirical data

Early attempts at desistance from crime: Prisoners’ prerelease expectations and their postrelease criminal behavior

Recent attention has been paid to the role of a positive outlook in early stages of the desistance process. The aim of this article is to examine prisoners’ own expectations regarding future offending before they are released, and why these expectations come true or not after their release from prison. Longitudinal data were used from in-depth interviews with 24 prisoners who were interviewed at the end of their sentence and three months after release about their future outlook on criminal activities, social capital and agency factors, and current criminal activities. Findings suggest a strong connection between criminal and non-criminal expectations and post-release criminal behavior.Criminal Justice: Legitimacy, accountability, and effectivit