43 research outputs found
Introduction of a portable ultrasound unit into the health services of the Lugufu refugee camp, Kigoma District, Tanzania
The Impact of Schistosoma japonicum Infection and Treatment on Ultrasound-Detectable Morbidity: A Five-Year Cohort Study in Southwest China
Schistosomiasis is a water-borne parasite that infects approximately 200 million people worldwide. Schistosoma japonicum, found in Asia, causes disease by releasing eggs in the liver, leading to fibrosis, anemia, and, in children, impaired growth. Ultrasound can assess liver pathology from schistosomiasis; however more information is needed to evaluate the relevance of standard ultrasound measures. We followed 578 people for up to five years, testing for schistosomiasis infection and conducting ultrasound examinations to assess the relationship between infection and seven ultrasound measures and to evaluate the impact of treatment with anti-schistosomiasis chemotherapy (praziquantel) on morbidity. All infections were promptly treated. Fibrosis of the liver parenchyma, pathology unique to S. japonicum, was associated with schistosomiasis infection, and was most advanced in people with high worm burdens. Liver fibrosis declined significantly following treatment, but reversal of severe liver fibrosis was rare. Other ultrasound measures were not consistently related to schistosomiasis infection or treatment. These findings suggest parenchymal fibrosis can be used to measure morbidity attributable to S. japonicum and evaluate the impact of disease control efforts. Because reversal of severe fibrosis was limited, disease control efforts will be most effective if they can not only treat existing infections but also prevent new infections
Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
Currently there are few studies characterising the nature and aetiology of human schistosome-related inflammatory processes. The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also known as YKL-40, a molecule associated with inflammatory processes, and schistosome infection, morbidity and systemic cytokine levels.
Methods
Serological levels of CHI3L1 and a panel of cytokines (IFN-y, IL-4/5/6/9/10/13 and 17) were measured in two Zimbabwean populations resident in a high and low schistosome infection area. CHI3L1 levels were related to schistosome infection, haematuria status and cytokine levels after allowing for confounding variables. The effect of antihelminthic treatment with praziquantel on CHI3L1 levels was determined in 246 participants 6 weeks post-treatment.
Results
CHI3L1 levels increased with age in both areas but were significantly higher in the high infection areas compared to the low infection area. CHI3L1 levels were also higher in infected compared to uninfected individuals with this difference being significant in the youngest age group. Curative antihelminthic treatment resulted in a significant decrease in CHI3L1 levels. Of the cytokines, only IL-10 and IL-17 had a significant association with CHI3L1 levels, and this association was negative.
Conclusions
Serum CHI3L1 levels differ between infected and uninfected people before and after antihelminthic treatment. The greatest difference occurs in the youngest age group, in keeping with the period when schistosome-related pathological processes are initiated. Following from previous studies in non-infectious diseases showing that CHI3L1 is a biomarker for the inflammatory process, this study suggests that the potential for CHI3L1 as a biomarker for schistosome-related pathology should be explored further.World Health Organisation (www.who.org); the Wellcome Trust (http://www.wellcome.ac.uk/) [grant number WT082028MA]; the Thrasher Foundation (http://www.thrasherresearch.org/) to [FM]; and by the Medical Research Council (http://www.mrc.ac.uk) [grant number G0600818 to JEA, PhD studentship LJA-544 to LJA]
Disagreement between ultrasound and magnetic resonance imaging in the identification of schistosomal periportal fibrosis
Imaging techniques and histology in the evaluation of liver fibrosis in hepatosplenic schistosomiasis mansoni in Brazil: a comparative study
Ultrasonography in schistosomiasis in Africa
Approximately 50 publications have become available in the
international literature on ultrasonography in schistosomiasis in
Africa. Geographically these cover Congo, Egypt, Kenya, Mali,
Mauritius, Niger, Senegal, Sudan, Tanzania and East African Islands as
well as Zimbabwe. Further studies are ongoing in many countries, such
as Burundi, Ghana, Madagaskar and Uganda. It was shown that
ultrasonography is useful in the detection of morbidity induced by
schistosomiasis on an individual basis and on the community level.
There is indication for varying morbidity patterns in different African
foci. Post-treatment monitoring has provided evidence for reversibility
of pathological lesions induced by Schistosoma (S.) haematobium and S.
mansoni, even though evidence for reversibility of periportal fibrosis
in adults is not yet satisfactorily substantiated. A standardized set
of criteria for ultrasonographical observations has been worked out and
is presently in the process of being refined. It is thus hoped that
standardization will contribute to render studies in different endemic
settings comparable on a global basis