Predicting success for new flavors with information known pre-launch: a flavored snack food case study

Success in the marketplace is the goal of every product launch. Knowing what data to collect before launching a product that could predict success would be valuable to companies. Thus, the objective of this study was to determine whether success of new line extensions for a multi-flavored snack product available internationally could be predicted from information available before launch. Staff from 15 countries completed a questionnaire for each product and included questions related to authenticity, familiarity, and capturing current trends, packaging and market place issues such as product competition and pricing. Using 63 flavors, a discriminant function correctly identified 75.8% successful products as successful and 66.7% unsuccessful products as unsuccessful. Stepwise comparison determined the variables necessary to correctly categorize the snack products: being a trendy flavor, new to the category, based off foods from restaurants or traditional foods. These variables assisted in predicting in market success for this product category

Developing a Messaging Graphic for Storage Times of Refrigerated Ready to Eat (RTE) Foods for a Consumer Food Safety Health Campaign

This study developed and evaluated risk communication messages for ready to eat (RTE) foods targeted towards consumer storage practices in a food safety health campaign. Concepts were determined from a fractional factorial design of five categories of attributes potentially present in health promotion: title, message, graphic, slogan, and icon. Consumers viewed a subset of concepts and scored how useful the concept was in remembering to throw away RTE foods that were stored too long. Regression analysis determined which combinations of message attributes were most likely to result in using the information to throw out foods, which could help prevent foodborne illness. Findings showed that for this type of information, a graphic is a critical element for the printed schematic. The slogan (i.e., a short statement similar to a jingle or tag-line in a commercial) may be important to consumers, but the icon was not important

Determining a sensory model for predicting successful and unsuccessful products: a case study of flavors for a snack category

Doctor of PhilosophyDepartment of Human NutritionEdgar Chambers IVCompanies introduce new products with the goal of achieving success. However, many products fail. The overall objective of this research was to design processes for determining sensory and market characteristics of food products that could predict success. The first sub-objective was to determine if success could be predicted using information known before launch. The second sub-objective was to describe a process for determining specific sensory characteristics that promote success. Most methods chosen for this research are commonly used. However, previous research has identified a relationship between consumers liking and salivation, without defining a method. Thus, three salivation methods were selected for initial testing: spit, cotton rolls and sensory scale. These were tested on foods with different textures. Although all methods gave similar results, the spit method was chosen for further testing of flavor differences. Differences in salivation measurements were found for snacks where flavors were different but texture was unchanged. Next, flavored snack products from 15 countries were selected that were successful or had failed. Questionnaires were completed for each product and included questions related to authenticity, familiarity, current trends, packaging and marketplace issues such as product competition and pricing, all of which would be known before launch. A discriminant function was developed that correctly identified 75.8% of the successful flavored snack products as successful and 66.7% of the unsuccessful products as unsuccessful. Stepwise comparisons were used to determine that four variables are necessary to correctly categorize these products. The products then were clustered into three groups to select 34 products from 11 countries for further sensory testing. Information from extensive sensory descriptive methods were evaluated individually and in various combinations through stepwise regression and discriminant analysis. The final sensory model correctly predicted all successful and unsuccessful products, had an R-square of 0.84 and included nine regression factors: seven flavor attributes and two flavor attribute ratios. Many of the attributes were base flavor notes necessary for this flavored snack category. A process for selecting key attributes for success was described. For this snack category, creating products with flavors that interact well with base flavor notes can lead to a successful product

Developing a messaging graphic for storage times of refrigerated ready to eat, RTE, foods for a consumer food safety health campaign

This study developed and evaluated risk communication messages for ready to eat (RTE) foods targeted towards consumer storage practices in a food safety health campaign. Concepts were determined from a fractional factorial design of five categories of attributes potentially present in health promotion: title, message, graphic, slogan, and icon. Consumers viewed a subset of concepts and scored how useful the concept was in remembering to throw away RTE foods that were stored too long. Regression analysis determined which combinations of message attributes were most likely to result in using the information to throw out foods, which could help prevent foodborne illness. Findings showed that for this type of information, a graphic is a critical element for the printed schematic. The slogan (i.e., a short statement similar to a jingle or tag-line in a commercial) may be important to consumers, but the icon was not important

Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria

Importance: Polymicrogyria is the most commonly diagnosed cortical malformation and is associated with neurodevelopmental sequelae including epilepsy, motor abnormalities, and cognitive deficits. Polymicrogyria frequently co-occurs with other brain malformations or as part of syndromic diseases. Past studies of polymicrogyria have defined heterogeneous genetic and nongenetic causes but have explained only a small fraction of cases. Objective: To survey germline genetic causes of polymicrogyria in a large cohort and to consider novel polymicrogyria gene associations. Design, Setting, and Participants: This genetic association study analyzed panel sequencing and exome sequencing of accrued DNA samples from a retrospective cohort of families with members with polymicrogyria. Samples were accrued over more than 20 years (1994 to 2020), and sequencing occurred in 2 stages: panel sequencing (June 2015 to January 2016) and whole-exome sequencing (September 2019 to March 2020). Individuals seen at multiple clinical sites for neurological complaints found to have polymicrogyria on neuroimaging, then referred to the research team by evaluating clinicians, were included in the study. Targeted next-generation sequencing and/or exome sequencing were performed on probands (and available parents and siblings) from 284 families with individuals who had isolated polymicrogyria or polymicrogyria as part of a clinical syndrome and no genetic diagnosis at time of referral from clinic, with sequencing from 275 families passing quality control. Main Outcomes and Measures: The number of families in whom genetic sequencing yielded a molecular diagnosis that explained the polymicrogyria in the family. Secondarily, the relative frequency of different genetic causes of polymicrogyria and whether specific genetic causes were associated with co-occurring head size changes were also analyzed. Results: In 32.7% (90 of 275) of polymicrogyria-affected families, genetic variants were identified that provided satisfactory molecular explanations. Known genes most frequently implicated by polymicrogyria-associated variants in this cohort were PIK3R2, TUBB2B, COL4A1, and SCN3A. Six candidate novel polymicrogyria genes were identified or confirmed: de novo missense variants in PANX1, QRICH1, and SCN2A and compound heterozygous variants in TMEM161B, KIF26A, and MAN2C1, each with consistent genotype-phenotype relationships in multiple families. Conclusions and Relevance: This study's findings reveal a higher than previously recognized rate of identifiable genetic causes, specifically of channelopathies, in individuals with polymicrogyria and support the utility of exome sequencing for families affected with polymicrogyria..SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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