Third Order Hamiltonian for a Binary System with Varying Masses Including Preastron Effect

This work concerns of the effects of the variation in the masses for two attracting bodies on the orbiter orbital elements. The formulation of the problem was done in different kind of mechanics, Newtonian, Lagrangian, and Hamiltonian. Moreover, constructing the Hamiltonian function of the varying masses of a binary system including, periastron effect, in canonical form in the extended phase space, up to third order of the small parameter ?, to be able to solve using canonical perturbation techniques. Canonical perturbation method based on Lee transformation was developed by Kamel used to remove the short periodic terms from the Hamiltonian to be able to solve the system of equations. The Hamiltonian of the system was transformed to the extended phase space by introducing two variable represents the variation of the masses and their conjugate momenta. Finally, Hamilton's equation of motions was used to drive general formula to calculate the variations in the elements due to the variations in their masses and what so called periastron effects

Transfusion transmitted virus and dengue virus among healthy blood donors: A prevalence report from Jordan

Transfusion transmitted virus (TTV) is thought to contribute to non-A non-E hepatitis and other diseases. Dengue virus (DENV) is a serious mosquito-borne pathogen. Reports on TTV and DENV in Jordan and the Middle East and North Africa region are limited. Herein, the prevalence of TTV antigen and anti-DENV IgG antibodies among apparently healthy blood donors from Northern Jordan and the Northern Agwar region of Jordan was investigated using an enzyme-linked immunosorbent assay. Chi-square test and binary logistic regression were used to correlate positivity with possible infection risk factors (age, sex, residence location, and occupation). One hundred ninety apparently healthy blood donors were included in the study (age 18 - 54 years). TTV antigen was detected in 17.9% of the samples. Lower antigen positivity was observed among Agwar residents than non-residents (7.1% vs 24.5%; chi-square test P < 0.001), which was confirmed by regression analysis (odds ratio 0.262 [95% confidence interval 0.086-0.805]; P = 0.019). Antigen positivity did not differ by age, sex, or occupation. Seropositivity for anti-DENV IgG was 17.9%. Seropositivity did not differ by age, sex, or occupation. Higher seropositivity was observed among Agwar residents than non-residents (36.1% vs 9.4%; chi-square test P < 0.001), which was confirmed by regression analysis (odds ratio 5.420 [95% confidence interval 2.377-12.359]; P < 0.001). Overall, low TTV antigen prevalence and DENV seroprevalence were found among blood donors from Northern Jordan and the Northern Agwar region of Jordan

Transfusion transmitted virus and dengue virus among healthy blood donors: A prevalence report from Jordan

Transfusion transmitted virus (TTV) is thought to contribute to non-A non-E hepatitis and other diseases. Dengue virus (DENV) is a serious mosquito-borne pathogen. Reports on TTV and DENV in Jordan and the Middle East and North Africa region are limited. Herein, the prevalence of TTV antigen and anti-DENV IgG antibodies among apparently healthy blood donors from Northern Jordan and the Northern Agwar region of Jordan was investigated using an enzyme-linked immunosorbent assay. Chi-square test and binary logistic regression were used to correlate positivity with possible infection risk factors (age, sex, residence location, and occupation). One hundred ninety apparently healthy blood donors were included in the study (age 18 - 54 years). TTV antigen was detected in 17.9% of the samples. Lower antigen positivity was observed among Agwar residents than non-residents (7.1% vs 24.5%; chi-square test P < 0.001), which was confirmed by regression analysis (odds ratio 0.262 [95% confidence interval 0.086-0.805]; P = 0.019). Antigen positivity did not differ by age, sex, or occupation. Seropositivity for anti-DENV IgG was 17.9%. Seropositivity did not differ by age, sex, or occupation. Higher seropositivity was observed among Agwar residents than non-residents (36.1% vs 9.4%; chi-square test P < 0.001), which was confirmed by regression analysis (odds ratio 5.420 [95% confidence interval 2.377-12.359]; P < 0.001). Overall, low TTV antigen prevalence and DENV seroprevalence were found among blood donors from Northern Jordan and the Northern Agwar region of Jordan

Hydrogen underground storage efficiency in a heterogeneous sandstone reservoir

Underground hydrogen storage has been recognized as a key technology for storing enormous amounts of hydrogen, thus aiding in the industrial-scale application of a hydrogen economy. However, underground hydrogen storage is only poorly understood, which leads to high project risk. This research thus examined the effect of caprock availability and hydrogen injection rate on hydrogen recovery factor and hydrogen leakage rate to address some fundamental questions related to underground hydrogen storage. A three dimensional heterogeneous reservoir model was developed, and the impact of caprock and hydrogen injected rate on hydrogen underground storage efficiency were analysed with the model. The results indicate that both caprock and injection rate have an important impact on hydrogen leakage, and the quantities of trapped and recovered hydrogen. It is concluded that higher injection rate increases H2 leakage when caprocks are absent. In addition, lower injection rates and caprock availability increases the amount of recovered hydrogen. This work therefore provided fundamental information regarding underground hydrogen storage project assessment, and supports the decarbonisation of the energy supply chain.Cited as: Mahdi, D. S., Al-Khdheeawi, E. A., Yuan, Y., Zhang, Y., Iglauer, S. Hydrogen underground storage efficiency in a heterogeneous sandstone reservoir. Advances in Geo-Energy Research, 2021, 5(4): 437-443, doi: 10.46690/ager.2021.04.0

Evaluation of the efficacy of oral ivermectin in comparison with ivermectin–metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum

SummaryObjectiveTo evaluate the efficacy of ivermectin and combined ivermectin–metronidazole therapy in the treatment of ocular and skin lesions of Demodex folliculorum.MethodsOne hundred twenty patients with skin lesions and anterior blepharitis, whose infestation was treatment-resistant and who had a Demodex count >5 mites/cm2 for skin lesions or ≥3 mites at the root of each eyelash, were recruited. The treatment regimens were ivermectin and ivermectin–metronidazole combined therapy. We enrolled 15 patients from each of four groups for each treatment regimen. Demodex was detected by standardized skin surface biopsy for skin lesions. Three eyelashes from each affected lower eyelid were epilated and examined. The study subjects were followed-up once a week for four visits.ResultsThere was a difference in the mite count between the subgroups taking ivermectin and combined therapy during all follow-up visits. At the last visit, in the combined therapy subgroup, 1.7% of patients showed no clinical improvement, 26.7% showed a marked clinical improvement, and 71.6% showed complete remission. In those on the ivermectin regimen, 27 patients had a mite count >5 mites/cm2, 21.7% showed no clinical improvement, 33.3% showed a marked improvement, and 45% showed complete remission.ConclusionsCombined therapy was superior in decreasing the D. folliculorum count in all groups and in reducing the mite count to the normal level in rosacea and in anterior blepharitis. On the other hand, the two regimens were comparable in reducing the mite count to the normal level in acne and peri-oral dermatitis lesions

Investigation of infill wall effect on inelastic response of structures

Experience of recent earthquake proved that infill wall contributes to the behaviour of structures subjected to earthquake or any vibration loads. Although the infill wall is not considered during design process, as it is not a structural element. However, the function of infill wall during vibration of building has not been investigated comprehensively. Therefore, in this study, the influence of RC infill wall on seismic performance of the RC building during earthquake excitation is evaluated. For this purpose, a four-storey building; with and without RC infill wall elements is considered and finite element model is developed to study the influence of this RC infill wall in seismic response of building. Linear static, linear dynamic, nonlinear static (push over) and nonlinear dynamic (time history) analyses were all applied to the specified model for developing the finite element model of this building. On the other hand, an experimental study was carried out to verify the influence of the RC infill wall on the RC frame. The results indicated that utilizing RC infill wall can improve the response of the framed structure effectively during earthquake occurrence. It was also observed that adding infill wall in the outside bays of the four-storey building decreased the displacement of the structural nodes both in x and y directions and decreased their rotation around they and z axis. In addition, addition of RC infill walls reduced the axial forces in the columns and beams in the whole structure. Besides, a clear reduction in the shear forces was observed in the columns and beams. The moment around the beams and columns along the z axis was reduced after addition of the RC infill walls

Factors associated with early growth in Egyptian infants: implications for addressing the dual burden of malnutrition.

Optimal nutrition is critical to the attainment of healthy growth, human capital and sustainable development. In Egypt, infants and young children face overlapping forms of malnutrition, including micronutrient deficiencies, stunting and overweight. Yet, in this setting, little is known about the factors associated with growth during the first year of life. A rise in stunting in Lower Egypt from 2005 to 2008 prompted this implementation research study, which followed a longitudinal cohort of infants from birth to 1 year of age within the context of a USAID-funded maternal and child health integrated programme. We sought to determine if growth patterns and factors related to early growth differed in Lower and Upper Egypt, and examined the relationship between weight loss and subsequent stunting at 12 months of age. Growth patterns revealed that length-for-age z-score (LAZ) decreased and weight-for-length z-score (WLZ) increased from 6 to 12 months of age in both regions. One-quarter of infants were stunted and nearly one-third were overweight by 12 months of age in lower Egypt. Minimum dietary diversity was significantly associated with WLZ in Lower Egypt (β = 0.22, P \u3c 0.05), but not in Upper Egypt. Diarrhoea, fever and programme exposure were not associated with any growth outcome. Weight loss during any period was associated with a twofold likelihood of stunting at 12 months in Lower Egypt, but not Upper Egypt. In countries, like Egypt, facing the nutrition transition, infant and young child nutrition programmes need to address both stunting and overweight through improving dietary quality and reducing reliance on energy-dense foods

HIRA directly targets the enhancers of selected cardiac transcription factors during in vitro differentiation of mouse embryonic stem cells

HIRA is a histone chaperone known to modulate gene expression through the deposition of H3.3. Conditional knockout of Hira in embryonic mouse hearts leads to cardiac septal defects. Loss of function mutation in HIRA, together with other chromatin modifiers, was found in patients with congenital heart diseases. However, the effects of HIRA on gene expression at earlier stages of cardiogenic mesoderm differentiation have not yet been studied. Differentiation of mouse embryonic stem cells (mESCs) towards cardiomyocytes mimics some of these early events and is an accepted model of these early stages. We performed RNA-Seq and H3.3-HA ChIP-seq on both WT and Hira-null mESCs and early cardiomyocyte progenitors of both genotypes. Analysis of RNA-seq data showed differential down regulation of cardiovascular development-related genes in Hira-null cardiomyocytes compared to WT cardiomyocytes. We found HIRA-dependent H3.3 deposition at these genes. In particular, we observed that HIRA influenced directly the expression of the transcription factors Gata6, Meis1 and Tbx2, essential for cardiac septation, through H3.3 deposition. We therefore identified new direct targets of HIRA during cardiac differentiation

Factors associated with early growth in Egyptian infants: implications for addressing the dual burden of malnutrition

Optimal nutrition is critical to the attainment of healthy growth, human capital and sustainable development. In Egypt, infants and young children face overlapping forms of malnutrition, including micronutrient deficiencies, stunting and overweight. Yet, in this setting, little is known about the factors associated with growth during the first year of life. A rise in stunting in Lower Egypt from 2005 to 2008 prompted this implementation research study, which followed a longitudinal cohort of infants from birth to 1 year of age within the context of a USAID-funded maternal and child health integrated programme. We sought to determine if growth patterns and factors related to early growth differed in Lower and Upper Egypt, and examined the relationship between weight loss and subsequent stunting at 12 months of age. Growth patterns revealed that length-for-age z-score (LAZ) decreased and weight-for-length z-score (WLZ) increased from 6 to 12 months of age in both regions. One-quarter of infants were stunted and nearly one-third were overweight by 12 months of age in lower Egypt. Minimum dietary diversity was significantly associated with WLZ in Lower Egypt (β = 0.22, P < 0.05), but not in Upper Egypt. Diarrhoea, fever and programme exposure were not associated with any growth outcome. Weight loss during any period was associated with a twofold likelihood of stunting at 12 months in Lower Egypt, but not Upper Egypt. In countries, like Egypt, facing the nutrition transition, infant and young child nutrition programmes need to address both stunting and overweight through improving dietary quality and reducing reliance on energy-dense foods

Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients

Purpose: Although there is an established role for microbiome dysbiosis in the pathobiology of colorectal cancer (CRC), CRC patients of various race/ethnicities demonstrate distinct clinical behaviors. Thus, we investigated microbiome dysbiosis in Egyptian, African American (AA), and European American (EA) CRC patients. Patients and methods: CRCs and their corresponding normal tissues from Egyptian (n = 17) patients of the Alexandria University Hospital, Egypt, and tissues from AA (n = 18) and EA (n = 19) patients at the University of Alabama at Birmingham were collected. DNA was isolated from frozen tissues, and the microbiome composition was analyzed by 16S rRNA sequencing. Differential microbial abundance, diversity, and metabolic pathways were identified using linear discriminant analysis (LDA) effect size analyses. Additionally, we compared these profiles with our previously published microbiome data derived from Kenyan CRC patients. Results:Differential microbiome analysis of CRCs across all racial/ethnic groups showed dysbiosis. There were high abundances of Herbaspirillum and Staphylococcus in CRCs of Egyptians, Leptotrichia in CRCs of AAs, Flexspiria and Streptococcus in CRCs of EAs, and Akkermansia muciniphila and Prevotella nigrescens in CRCs of Kenyans (LDA score \u3e4, adj. p-value Conclusions: Our findings showed altered mucosa-associated microbiome profiles of CRCs and their metabolic pathways across racial/ethnic groups. These findings provide a basis for future studies to link racial/ethnic microbiome differences with distinct clinical behaviors in CRC