Doe Dose

A plastic fawn, palm-sized, lives on my office desk. He gazes at my open office door. His right front hoof is raised, poised for haste. The deer of my Mississippi childhood were the Virginia whitetail, Odocoileus virginianus virginianus. As a child ten years or so, fresh from reading Felix Salten’s Bambi, I rested my forehead against backseat car windows and took in miles and miles of Mississippi forest. Commutes between school and our isolated house were long. I imagined myself a whitetailed doe, keeping up with the car through those woods, a blur of velvet hide and muscle. I now walk to campus in Gettysburg, Pennsylvania. The odocoileus virginianus virginianus, the Virginia whitetail, emerge from the battlefields, animal grace among memorials and hardwoods. My round-eyed dog and I greet all deer with silence when we exercise in the morning light. [excerpt

Enforcing Internationally Recognized Human Rights Violations under the Alien Tort Claims Act: An Analysis of the Ninth Circuit’s Decision in Doe v. Unocal Corp.

[Excerpt] On September 18, 2002, the Ninth Circuit Court of Appeals ruled that a United States based corporation can be held civilly liable for “aiding and abetting” the internationally recognized human rights violation of forced labor. This case, Doe v. Unocal Corp.1 (Doe II), is significant for its ramifications to human rights litigation in United States courts as well as to future liability for multinational corporations conducting commerce in foreign states. The uniqueness of this case is found in its precedent. No prior federal court has held a corporation liable for human rights violations under the Alien Tort Claims Act. […] This article concerns the third category, in particular, an analysis of Doe II. This article analyzes Doe II under a multi-tiered rubric. The first tier involves analyzing whether the Ninth Circuit was correct in its jurisdictional interpretation. The second tier studies the extent to which the Ninth Circuit’s use of international law expanded previously accepted usage by United States courts. For example, after reading Doe II, a question arises as to whether the Ninth Circuit created a “complete” universal jurisdiction for torts under the ATCA. The final tier, involves analyzing foreseen legal consequences. That is, does Doe II expand causes of action for foreign human rights violations because the decision reduces possible defenses to tort claims under the ATCA? Within this multi-dimensional rubric, Doe II must be understood from its beginnings. Section II discusses the history of Doe II, primarily through two prior district court decisions. However, in order to analyze Doe II, a meaningful background to the ATCA must be determined. Section III of this paper provides this background. Particular attention is paid to the Filartiga decision and its progeny because Doe II relied, in large-part, on principles established in Filartiga. Section IV provides context for the suit, namely, the nature of human rights violations occurring in Myanmar where the plaintiffs allege the violations occurred. Section V analyzes the Ninth Circuit’s unique application of International Law. Section VI analyzes foreseeable consequences to defenses against ATCA suits. In particular, defenses under the act of state doctrine, dismissal under the indispensable parties rule, and forum non conveniens are addressed. This article concludes with the final assessment that while Doe II is rooted in fundamentally correct interpretations of the law, it both expands the parameters of corporate liability and it fundamentally alters the ability to defend against ATCA suits

Higher Ground: A Hoosier Soldier\u27s Search for Religious Identity in the Korean War

This paper focuses on Private Joe Doe, a Hoosier soldier in the Korean War who struggled with the conflict between conservative Christian beliefs and modernity. The author reviewed 85 letters that Doe sent home to his mother, in addition to Private Doe’s mother’s memoirs and the evangelical literature that Doe encountered in his formative years. Although Doe had been socialized to believe that the church solved the most pressing problems, his experiences also underscored the power of modern science, New Deal programs, public education, and changing roles of women. This is a case study of a young Hoosier soldier’s search for religious identity

Introducing First Year Medical Students to Personalized Medicine Concepts in a Small Group Activity

Presented as a Poster Presentation at 2020 IUSM Education Day.An individuals’ genetic profile is becomingly an increasingly important parameter in healthcare decisions. This small group activity was developed to introduce first year medical students in the Molecules to Cells and Tissues course to the concept and significance of Pharmacogenomics and personalized medicine. Additionally, this activity provided students with an opportunity to work with a large dataset and use the information to impact clinical decision making. This activity has two cases, takes student groups approximately 2 hours to complete, and requires internet access. Case materials are available through the learning management system Canvas, and include open-ended questions to guide students through the cases. In these cases students explore the functional significance of different alleles of a panel of cytochrome P450 genes. The group activity has the students examine a large data set of cytochrome P450 genes and cognate alleles to determine their prevalence in the local population and calculate the individuals’ gene scores. The students are then asked to explain the impact of the genotype (or gene score) on the resulting patient phenotype (i.e. the functional significance of the genotype). The first case involves a breast cancer survivor support group in which patients taking Taxol discuss lack of adequate pain relief from opioids and the potential impact of concomitant use of natural compounds/supplements on drug metabolism. The second case involves a patient presenting with recurrent stroke-like symptoms despite being on the anticoagulant medication clopidogrel. The patient is initially suspected to be non-compliant, but is later determined to be a poor metabolizer of the anticoagulant clopidogrelto its active form thus decreasing its efficacy. The expertise of the IUSM Medical Genetics research faculty was leveraged to provide a large data set of cytochrome P450 genes and cognate alleles. The selection of cytochrome P450 was based upon delivering content focused on the biochemistry of the enzyme system and provided an opportunity to highlight the drug interaction database available through IUSM Clinical Pharmacology (The FlockhartTable™ ; https://drug-interactions.medicine.iu.edu/). The addition of natural compounds was to draw students’ attention to the Natural Medicines database, which is the recommended source for evidence-based data on complementary and alternative medicine. Natural Medicines is available through the Ruth Lilly Medical Library and can be searched by substance or condition. It provides both a summary of the literature available on substances as well as the level of evidence or quality of studies done on the substance

Design of experiments for non-manufacturing processes : benefits, challenges and some examples

Design of Experiments (DoE) is a powerful technique for process optimization that has been widely deployed in almost all types of manufacturing processes and is used extensively in product and process design and development. There have not been as many efforts to apply powerful quality improvement techniques such as DoE to improve non-manufacturing processes. Factor levels often involve changing the way people work and so have to be handled carefully. It is even more important to get everyone working as a team. This paper explores the benefits and challenges in the application of DoE in non-manufacturing contexts. The viewpoints regarding the benefits and challenges of DoE in the non-manufacturing arena are gathered from a number of leading academics and practitioners in the field. The paper also makes an attempt to demystify the fact that DoE is not just applicable to manufacturing industries; rather it is equally applicable to non-manufacturing processes within manufacturing companies. The last part of the paper illustrates some case examples showing the power of the technique in non-manufacturing environments

Revisiting soliton contributions to perturbative amplitudes

Open Access funded by SCOAP3. CP is a Royal Society Research Fellow and partly supported by the U.S. Department of Energy under grants DOE-SC0010008, DOE-ARRA-SC0003883 and DOE-DE-SC0007897. ABR is supported by the Mitchell Family Foundation. We would like to thank the Mitchell Institute at Texas A&M and the NHETC at Rutgers University respectively for hospitality during the course of this work. We would also like to acknowledge the Aspen Center for Physics and NSF grant 1066293 for a stimulating research environment