Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities

In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-beta-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, alpha-amylase, and alpha- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program's help

Wellesley College 1875-1975: A Century of Women

https://repository.wellesley.edu/wellesleyhistories/1000/thumbnail.jp

Novel Quinoline-Based Thiosemicarbazide Derivatives: Synthesis, DFT Calculations, and Investigation of Antitubercular, Antibacterial, and Antifungal Activities

The discovery of new antimicrobial agents as a means of treating drug-resistant microbial pathogens is of utmost significance to overcome their immense risk to human well-being. The current investigation involves the development, synthesis, and assessment of the antimicrobial efficacy of novel quinoline derivatives incorporating a thiosemicarbazide functionality. To design the target compounds (QST1–QST14), we applied the molecular hybridization approach to link various thiosemicarbazides to the quinoline core with a sulfonyl group. Upon the synthesis and completion of structural characterization via spectroscopic techniques (1H NMR, 13C NMR, 15N NMR, IR, and HRMS), the title molecules were extensively evaluated for their potential antitubercular, antibacterial, and antifungal activities. N-(3-Chlorophenyl)-2-(quinolin-8-ylsulfonyl)hydrazine-1-carbothioamide (QST4), the most effective compound against Mycobacterium tuberculosis H37Rv, was also tested on isoniazid-resistant clinical isolates with katG and inhA promoter mutations. Based on molecular docking studies, QST4 was also likely to demonstrate its antimycobacterial activity through inhibition of the InhA enzyme. Furthermore, three derivatives (QST3, QST4, and QST10) with preferable antimicrobial and drug-like profiles were also shown to be nontoxic against human embryonic kidney (HEK) cells. All compounds were optimized by the density functional theory method using B3LYP with the 6-31+G(d,p) basis set. Structural analysis, natural bond orbital calculations of donor–acceptor interactions, molecular electrostatic potential analysis, and frontier molecular orbital analysis were carried out. Quantum chemical descriptors and charges on the atoms were determined to compare the strengths of the intramolecular hydrogen bonds formed and their stabilities. We determined that the sulfur atom forms a stronger intramolecular hydrogen bond than the nitrogen, oxygen, and fluorine atoms in these sulfonyl thiosemicarbazide derivatives

Towards the new Thematic Core Service Tsunami within the EPOS Research Infrastructure

Tsunamis constitute a significant hazard for European coastal populations, and the impact of tsunami events worldwide can extend well beyond the coastal regions directly affected. Understanding the complex mechanisms of tsunami generation, propagation, and inundation, as well as managing the tsunami risk, requires multidisciplinary research and infrastructures that cross national boundaries. Recent decades have seen both great advances in tsunami science and consolidation of the European tsunami research community. A recurring theme has been the need for a sustainable platform for coordinated tsunami community activities and a hub for tsunami services. Following about three years of preparation, in July 2021, the European tsunami community attained the status of Candidate Thematic Core Service (cTCS) within the European Plate Observing System (EPOS) Research Infrastructure. Within a transition period of three years, the Tsunami candidate TCS is anticipated to develop into a fully operational EPOS TCS. We here outline the path taken to reach this point, and the envisaged form of the future EPOS TCS Tsunami. Our cTCS is planned to be organised within four thematic pillars: (1) Support to Tsunami Service Providers, (2) Tsunami Data, (3) Numerical Models, and (4) Hazard and Risk Products. We outline how identified needs in tsunami science and tsunami risk mitigation will be addressed within this structure and how participation within EPOS will become an integration point for community development

Mültecilerin göç durumu ve STK'ların bu duruma etkisi

Yüksek lisans tezi...

Üç kameralı bir görüntü sisteminin geliştirilmesi ve geliştirilen bu sistem aracılığıyla atlarda eyer hareket analizi.

One of the purposes of this study is to develop a vision system consisting of 3 inexpensive, commercial cameras. The system is intended to be used for tracking the motion of objects in a large calibration volume, typically 6.5 m. wide and 0.7 m. high. Hence, a mechanism is designed and constructed for the calibration of the cameras. The second purpose of the study is to develop an algorithm, which can be used to obtain the kinematic data associated with a rigid body, using a vision system. Special filters are implemented in the algorithm to identify the 3 markers attached on the body. Optimal curves are fitted to the position data of the markers after smoothing the data appropriately. The outputs of the algorithm are the position, velocity and acceleration of any point (visible or invisible) on the body and the angular velocity and acceleration of the body. The singularities associated with the algorithm are also determined. Using the vision setup and the developed algorithm for tracking the kinematics of a rigid body, the motions of the saddles of different horses are investigated for different gaits. Similarities and differences between horses and/or gaits are analyzed to lead to quantitative results. Using the limits induced by the whole body vibration of humans, for the first time in the world, daily, allowable riding time and riding distances are determined for different horses and gaits. Furthermore, novel, quantitative horse comfort indicators are proposed. Via the experiments performed, these indicators are shown to be consistent with the comfort assessment of experienced riders. Finally, in order to implement the algorithms proposed in this study, a computer code is developed using MATLAB®.M.S. - Master of Scienc

Taş dolgu ve keson tipi dalgakıranların ekstrem dalgalar altında deneysel ve sayısal modelleme ile çalışılması.

Many coastal structures are designed without considering loads of long waves or extreme waves although they are constructed in areas prone to encounter these waves. Performance of two different types of coastal structures, rubble mound and caisson type breakwaters, is investigated under specified extreme wave conditions. In the first part of the study, laboratory experiments are conducted to observe the damage and failure phenomenon of the two types of breakwaters simultaneously which were designed according to wind waves but tested under six different extreme wave conditions. Pressure measurements along the front surface and bottom surface of the vertical wall in caisson type breakwater are also carried out within the physical model experiments for further investigation about the acting wave forces on the concrete blocks of the caisson breakwater. In the second part, the caisson type breakwater is modeled using a numerical software, IH-2VOF, which is one of the RANS models that can be applied to simulate hydrodynamic conditions around coastal structures. Two cases of the laboratory experiments are simulated by IH-2VOF model and pressure data is obtained from these simulations. Finally, the pressure measurements of laboratory experiments are compared with the results obtained from the numerical model, IH-2VOF and presented for two wave conditions along the front and bottom surfaces of vertical wall in caisson type breakwater.M.S. - Master of Scienc

A Research on the Opinions and Attitudes of Participatory Budget Applications of Manisa Metropolitan Municipality Central District Council Members

Modern budget systems have existed since the 1980s. Local government budgets include citizen demand and citizen participation, which are conceptualized in modern budget systems. Governance and participatory budget practices support active citizenship practices in local government budgets. Participatory budgeting is observed in many countries of the world. The first participatory budget was implemented in Porto Alegre, Brazil. It is stated that participatory budget implementation in Porto Alegre has been a pattern for other countries in the world. In this study, examples of New York and India are included. Çanakkale Municipality is the only official participatory budgeting pilot application in Turkey. In this study, after the conceptual framework of the participatory budget is described, Manisa Metropolitan Municipality central districts members’s opinions and attitudes will be covered. In the research, semi-structured interview method was conducted