UJI AKTIVITAS SEDIAAN KRIM EKSTRAK ETANOL HERBA SELEDRI (Apium graveolens L.) TERHADAP LUKA SAYAT PADA KELINCI (Oryctolagus cuniculus L.)

ABSTRACT Research has been carried out on the activity test of preparations for the ethanol extract of celery herbs (Apium graveolens L.) on vegetable wounds on rabbits (Oryctolagus cuniculus L). The aim of this study was to determine the activity of cream preparations for celery herb extract using concentrations of 2% b / v, 4% b / v and negative controls. The activity test was carried out on 2 rabbit test animals by carrying out the same 3 incisions on each rabbit's back with a length of 2 cm, 0.3 cm depth and 1 incision wound for negative control. The observation was carried out to see the pharmacological effects of the cream preparation, namely anti-inflammatory effect, proliferation, and its remodeling as an anti-inflammatory effect is swollen or red, while the proliferation effect is the formation of stopped granulation tissue after the entire surface is covered in the epithelium and the process of wound maturation, and while the remodeling effect is the phase that ends when the inflammation sign is gone. Keywords: Activity, Ethanol Extract, Herbs Celery (Apium graveolens L.), Cut wounds, Rabbits (Oryctolagus cuniculus L.) ABSTRAK Telah dilakukan penelitian tentang Uji Aktivitas Sediaan Krim Ekstrak Etanol Herba Seledri (Apium graveolens L.) Terhadap Luka Sayat Pada Kelinci (Oryctolagus cuniculus L). Penelitian ini bertujuan untuk mengetahui aktivitas sediaan krim ekstrak herba seledri dengan menggunakan konsentrasi 2% b/v, 4% b/v dan kontrol negatif. Uji aktivitas dilakukan pada 2 hewan uji kelinci dengan melakukan 3 luka sayat yang sama disetiap punggung kelinci dengan panjang 2 cm, kedalaman 0,3 cm dan 1 luka sayatan untuk kontrol negatif pengamatan dilakukan untuk melihat efek farmakologi dari sediaan krim tersebut yaitu efek anti inflamasi, proliferasi, dan remodelingnya yang dimaksud efek anti inflamasi adalah bengkak atau merah, sedangkan efek proliferasi adalah pembentukan jaringan granulasi berhenti setelah seluruh permukaan tertutup epitel dan proses pendewasaan luka, dan sedangkan efek remodelingnya adalah fase yang berakhir bila tanda radang sudah hilang. Kata kunci : Aktivitas, Ekstrak etanol, Herba Seledri (Apium graveolens L.), Luka sayat, Kelinci (Oryctolagus cuniculus L.

Pengaruh Pemberian Kombinasi Ekstrak Daun Kelor (Moringa Oleifera Lam) dan Ekstrak Daun Salam (Syzygium Polyanthum (Wight) Walp) Terhadap Penurunan Kadar Kolesterol Total Darah Pada Tikus Putih (Rattus Norvegicus)

Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi ekstrak daun Kelor (Moringa oleifera Lam) dan daun Salam (Syzygium polyanthum (Wight) Walp) terhadap penurunan kadar kolesterol yang diinduksi dengan propiltiourasil serta mengetahui dosis kombinasi ekstrak etanol daun Kelor dan daun Salam yang optimal untuk menurunkan kadar kolesterol darah tikus putih (Rattus norvegicus). Desain penelitian yang digunakan adalah eksperimental laboratorium yang di laksanakan di Laboratorium Farmakologi Jurusan Farmasi Yamasi. Penelitian ini menggunakan 15 ekor tikus putih yang di bagi menjadi 5 kelompok yang terdiri atas kelompok I sebagai control negatif dengan pemberian suspensi Na.CMC 1% b/v, kelompok II, III, IV sebagai kelompok perlakuan yang di berikan kombinasi ekstrak daun Kelor dan daun Salam masing-masing dengan perbandingan 1:1, 1:2, 2:1 Dan kelompok V di berikan suspensi atorvastatin sebagai kontrol positif. Hasil penelitian menujukkan bahwa pemberian kombinasi ekstrak Daun Kelor (Moringa oleifera Lam) dan Daun Salam (Syzygium polyanthum (Wight) Walp)menunjukkan efek penurunan kolesterol terhadap tikus putih (Rattus norvegicus) dan pemberian kombinasi ekstrak Daun Kelor (Moringa oleifera Lam) dan Daun Salam (Syzygium polyanthum (Wight) Walp) pada perbandingan 2:1 menunjukkan efek yang paling baik dan tidak berbeda nyata terhadap Atorvastatin dalam menurunkan kadar kolesterol total

FACTORS RELATED TO SELF MEDICATION IN PAI III OF BIRINGKANAYA SUBDISTRICT MAKASSAR

The research is how the level of knowledge of the PAI III Subsubdistrict of Biringkanaya Makassar in 2018 on the level of drug use without a prescription is self-medication. Independent variables in this study were age, education, income, source of information and place of medication for self-medication . Factors are most related to the cross sectional study design method for 63 samples taken with purposive sampling in the PAI III Biringkanaya subdistrict, Makassar.This type of research is observational analytic research, using the cross sectional study approach. This study is used to observe the level of self-medication, where in this case the independent variables and dependent variables, the study was observed simultaneously at the same time in each individual in the population.The results of this study indicate that the factors associated with self-medication in the PAI III sub-subdistrict are the source variables of getting the drug. The income level variable, age variable, education level and drug information source variable did not affect self-medication. Keywords: Self-Medication dan Related Problems Factor

Tinjauan Pengetahuan Masyarakat Kecamatan Panca Rijang Kabupaten Sidrap tentang Penggunaan Obat Tradisional

Pengobatan tradisional merupakan bentuk pelayanan pengobatan yang menggunakan cara, alat atau bahan yang tidak termasuk dalam standar pengobatan kedokteran modern dan dipergunakan sebagai alternatif pengobatan. Penggunaan tanaman obat untuk penyembuhan suatu penyakit didasarkan pada pengalaman yang secara turun – temurun yang diwariskan oleh generasi terdahulu kepada generasi berikutnya. Tanaman obat tradisional merupakan suatu komponen penting dalam pengobatan tradisional. Selain lebih ekonomis, efek samping dari obat tradisional sangat kecil. Karena itu, penggunaan obat tradisional dengan formulasi yang tepat sangat penting dan tentunya lebih aman dan efektif. Tujuan penelitian ini untuk mengetahui pengetahuan masyarakat Kecamatan Panca Rijang terhadap penggunaan obat tradisiona

Upaya Peningkatan Pengetahuan Tentang Penggunaan Obat Yang Rasional Melalui Penyuluhan Dagusibu, Konseling Obat Dan Pemeriksaan Kesehatan Gratis

Efforts To Increase Knowledge About the Rational Use Of Medicine Through Dagusibu Counseling, Drug Counseling, And Free Health ChecksThe high rate of self-medication in the community is due to the lack of public knowledge about the use of good and correct drugs. Several studies report that the level of public knowledge about drugs is still relatively low. The DAGUSIBU program exists as an effort to increase public knowledge about using and managing drugs. This service activity aims to find out the difference in knowledge changes before and after free health counseling and counseling by Syafiyah Medika Clinic Health officers. The method used is, method used in this service is to use a questionnaire in the form of a questionnaire to test public knowledge about the material given before and after the material exposure. Increasing Knowledge About Rational Use and Management of Drugs Through Dagusibu Counseling, Drug Counseling and Free Health Checks to the Community of Manggala Antang Village has been carried out well and received a very good response from participants, the total number of participants was 44 participants, which were dominated by women with a vulnerable age. most 51-70 years. The activities carried out experienced an increase in participants' knowledge from those before education/counseling by 14.14% and after the activities increased to 75.76%.Keywords: DAGUSIBU, Counseling; Hypertension; CholesterolTingginya angka pengobatan sendiri dari masyarakat ini disebabkan karena minimnya pengetahuan masyarakat terhadap penggunaan obat yang baik dan benar. Beberapa penelitian melaporkan bahwa tingkat pengetahuan masyarakat tentang obat masih terbilang rendah. Program DAGUSIBU hadir sebagai upaya meningkatkan pengetahuan masyarakat dalam menggunakan dan mengelola obat. Kegiatan pengabdian ini bertujuan untuk Mengetahui perbedaan perubahan pengetahuan sebelum dan sesudah penyuluhan dan konseling Kesehatan gratis oleh petugas Kesehatan Klinik Syafiyah Medika. Metode yang digunakan yaitu, Metode yang digunakan dalam pengabdian ini adalah dengan menggunakan angket berupa kuisioner untuk menguji pengetahuan masyarakat tentang materi yang diberikan sebelum dan setelah pemaparan materi. Peningkatan Pengetahuan  Tentang Penggunaan dan Pengelolaan Obat Yang Rasional Melalui Penyuluhan Dagusibu, Konseling Obat dan Pemeriksaan Kesehatan Gratis Kepada Masyarakat Kelurahan Manggala Antang telah terlaksana dengan baik dan mendapatkan respon yang sangat baik dari peserta, jumlah peserta keseluruhan sebanyak 44 peserta yang didominasi oleh Perempuan  dengan rentan usia terbanyak 51-70 tahun.  Kegiatan yang dilakukan mengalami peningkatan pengetahuan peserta dari yang sebelum edukasi/penyuluhan sebesar 14,14 % dan setelah kegiatan meningkat menjadi 75,76 % .Kata kunci : DAGUSIBU; Penyuluhan; Hipertensi; Kolestero

ANALYSIS OF THE USE OF DRUG CATEGORY OFF LABEL IN HOSPITAL PATIENTS AT HOSPITAL

The increasing use of off-label category drugs is the reason clinicians use these drugs because the clinical response has not had a significant impact on treatment as well as various reasons for specific therapeutic purposes. While adverse events and adverse reactions to drugs from off-label category drugs tend to continue to increase, so we need continuous and continuous data and study of therapies about the use of off-label category drugs. The purpose of this study was to analyze the characteristics of usage patterns and reasons for administering off-label categories of drugs to inpatients in hospitals. This research was conducted at the hospital. Dr. Wahidin Sudiro Husodo Makassar. Research uses data in the form of inpatient prescriptions in the internal medicine, children's and obgin's sections with a prescription number of 150 sheets. The results showed that the indication of disease using off-label category drugs was not dominated by one particular disease but rather based on the needs and conditions of the disease and the drug availability of the off label drug. The pattern of treatment using off-label categories of drugs given orally is the most dominant given by the clinician. The type of drug that is commonly used in the off-label category is not dominated by certain classifications, but drugs with indicated anti-pain are the choices for the type of drug used. The reason the clinician decides to use off-label category drugs is because the on-label category drugs have not been able to contribute to healing the diagnosis of the disease while some drugs based on experience for drugs that have not been approved can provide a significant healing process. Keywords; off-label category drug analysi

Analysis of the Relationship of Drug Side Effects and Tuberculosis Patient's Compliance After Treating With Drug Synthesis and Herbal Medicine

Most of the problems caused by long-term use of TB drugs are adverse drug reactions or side effects of the TB drugs. The high problem of TB in Indonesia is caused by, among other things, case finding and complete treatment, which are less rapid than the spread of the disease. The main goal of treating TB patients is to reduce mortality and morbidity and prevent transmission by curing patients. The prevalence of tuberculosis in men is 3 times higher than in women. The same is happening in other countries. This happens because men are more exposed to TB risk factors such as smoking, exposure to air in the work environment and lack of non-compliance to taking medication. The diverse composition of TB drugs with the aim of being antimicrobial makes drug side effects difficult to avoid so that patient compliance becomes a problem in carrying out TB treatment. The purpose of this study was to analyze the side effects of drugs that occur and the level of patient compliance to taking medicationand to analyze the relationship between the two effects. This research was a quantitative research with a cross sectional study design. This study used a survey method using a questionnaire instrument with the aim of analyzing the relationship between drug side effects and patient compliance. The sample size in this study was 200 respondents. The research locations were 4 community health centers (Puskesmas) and 1 Makassar community lung health center. Data processing and analysis techniques in this study used univariate and multivariate analysis which can be used to confirm that there is a relationship between drug side effects and patient compliance. The results showed that the side effects of drugs greatly affect patient compliance in carrying out TB treatment.Keywords: Drug side effects, patient compliance and tuberculosi

The Effect of God's Crown Fruit Extract and Cinnamon Extract On Decrease Total Cholesterol Levels In Rats White Male

God’s Crown contains chemicals that can cure various diseases including detoxification, anti-bacterial, anti-viral, lowering sugar levels, blood clotting in the body, anti-inflammatory, anti-oxidant, reducing fat deposits and cholesterol content in blood vessel walls. Cinnamon bark can lower blood glucose levels, total cholesterol, and triglyceride levels, and on the other hand can increase HDL levels. The purpose of this study was to determine the effect of giving God’s Crown Fruit Extract (Pheleria macrocarpa (Scheff.) Boerl) and Cinnamon Extract (Cinnamomum burmanii) on the reduction of total cholesterol levels in male white rats (Rattus norvegicus). The research method was Experimental Laboratory which was carried out at the Pharmacology and Phytochemical Laboratory, Faculty of Mathematics and Natural Sciences, Pancasakti University. The method used was propylthiouracil induction and high fat administration by measuring total cholesterol levels in male white rats using a glucometer. 15 male rats used were divided into 5 groups, namely negative control (CMC.Na 1% w/v), God’s Crown Fruit Extract and Cinnamon Extract, God’s Crown Fruit Extract 0.6% w/v, Wood Extract Sweet 1.2% w/v, positive control (Atorvastatin). Observations on the decrease in total cholesterol levels were carried out 1 day after treatment. Based on the results of the analysis using ANOVA with SPSS 25, the percentage reduction in total cholesterol levels showed that the administration of God’s Crown fruit extract and cinnamon extract, God’s Crown fruit extract 0.6% w/v, cinnamon extract 1.2% w/v , and atorvastatin showed the effect of reducing total cholesterol levels in male white rats and the administration of the fruit extract of God’s Crown and cinnamon extract which showed the best effect on reducing total cholesterol levels in male white rats.Keywords: Cholesterol, cinnamon, god's crown fruit