6,867 research outputs found
Tevatron-for-LHC Report of the QCD Working Group
The experiments at Run 2 of the Tevatron have each accumulated over 1 inverse
femtobarn of high-transverse momentum data. Such a dataset allows for the first
precision (i.e. comparisons between theory and experiment at the few percent
level) tests of QCD at a hadron collider. While the Large Hadron Collider has
been designed as a discovery machine, basic QCD analyses will still need to be
performed to understand the working environment. The Tevatron-for-LHC workshop
was conceived as a communication link to pass on the expertise of the Tevatron
and to test new analysis ideas coming from the LHC community. The TeV4LHC QCD
Working Group focussed on important aspects of QCD at hadron colliders: jet
definitions, extraction and use of Parton Distribution Functions, the
underlying event, Monte Carlo tunes, and diffractive physics. This report
summarizes some of the results achieved during this workshop.Comment: 156 pages, Tevatron-for-LHC Conference Report of the QCD Working
Grou
Bures volume of the set of mixed quantum states
We compute the volume of the N^2-1 dimensional set M_N of density matrices of
size N with respect to the Bures measure and show that it is equal to that of a
N^2-1 dimensional hyper-halfsphere of radius 1/2. For N=2 we obtain the volume
of the Uhlmann 3-D hemisphere, embedded in R^4. We find also the area of the
boundary of the set M_N and obtain analogous results for the smaller set of all
real density matrices. An explicit formula for the Bures-Hall normalization
constants is derived for an arbitrary N.Comment: 15 revtex pages, 2 figures in .eps; ver. 3, Eq. (4.19) correcte
Covariance and Fisher information in quantum mechanics
Variance and Fisher information are ingredients of the Cramer-Rao inequality.
We regard Fisher information as a Riemannian metric on a quantum statistical
manifold and choose monotonicity under coarse graining as the fundamental
property of variance and Fisher information. In this approach we show that
there is a kind of dual one-to-one correspondence between the candidates of the
two concepts. We emphasis that Fisher informations are obtained from relative
entropies as contrast functions on the state space and argue that the scalar
curvature might be interpreted as an uncertainty density on a statistical
manifold.Comment: LATE
Efficacy of lisdexamfetamine dimesylate throughout the day in children and adolescents with attention-deficit/hyperactivity disorder:results from a randomized, controlled trial
A Prograde, Low-Inclination Orbit for the Very Hot Jupiter WASP-3b
We present new spectroscopic and photometric observations of the transiting
exoplanetary system WASP-3. Spectra obtained during two separate transits
exhibit the Rossiter-McLaughlin (RM) effect and allow us to estimate the
sky-projected angle between the planetary orbital axis and the stellar rotation
axis, lambda = 3.3^{+2.5}_{-4.4} degrees. This alignment between the axes
suggests that WASP-3b has a low orbital inclination relative to the equatorial
plane of its parent star. During our first night of spectroscopic measurements,
we observed an unexpected redshift briefly exceeding the expected sum of the
orbital and RM velocities by 140 m/s. This anomaly could represent the
occultation of material erupting from the stellar photosphere, although it is
more likely to be an artifact caused by moonlight scattered into the
spectrograph.Comment: 23 pages, 4 figures, Accepted for publication in The Astrophysical
Journal, Replacement includes revised citation
Treatment response and remission in a double-blind, randomized, head-to-head study of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit hyperactivity disorder
The Author(s) 2014. This article is published with open access at Springerlink.com Objectives A secondary objective of this head-to-head study of lisdexamfetamine dimesylate (LDX) and ato-moxetine (ATX) was to assess treatment response rates in children and adolescents with attention-deficit hyperactiv-ity disorder (ADHD) and an inadequate response to methylphenidate (MPH). The primary efficacy and safety outcomes of the study, SPD489-317 (ClinicalTrials.gov NCT01106430), have been published previously. Methods In this 9-week, double-blind, active-controlled study, patients aged 6–17 years with a previous inadequate response to MPH were randomized (1:1) to dose-optimized LDX (30, 50 or 70 mg/day) or ATX (patients \70 kg: 0.5–1.2 mg/kg/day, not to exceed 1.4 mg/kg/day; patients C70 kg: 40, 80 or 100 mg/day). Treatment response was a secondary efficacy outcome and was predefined as a reduction from baseline in ADHD Rating Scale IV (ADHD-RS-IV) total score of at least 25, 30 or 50 %. Sustained response was predefined as a reduction from baseline in ADHD-RS-IV total score (C25, C30 or C50 %) or a Clinical Global Impressions (CGI)–Improvement (CGI–I) score of 1 or 2 throughout weeks 4–9. CGI– Severity (CGI–S) scores were also assessed, as an indicator of remission. Results A total of 267 patients were enrolled (LDX, n = 133; ATX, n = 134) and 200 completed the study (LDX, n = 99; ATX, n = 101). By week 9, significantly (p \ 0.01) greater proportions of patients receiving LDX than ATX met the response criteria of a reduction from baseline in ADHD-RS-IV total score of at least 25 % (90.5 vs. 76.7 %), 30 % (88.1 vs. 73.7 %) or 50 % (73.0 vs. 50.4 %). Sustained response rates were also signifi-cantly (p \ 0.05) higher among LDX-treated patient
Radio-frequency discharges in Oxygen. Part 1: Modeling
In this series of three papers we present results from a combined
experimental and theoretical effort to quantitatively describe capacitively
coupled radio-frequency discharges in oxygen. The particle-in-cell Monte-Carlo
model on which the theoretical description is based will be described in the
present paper. It treats space charge fields and transport processes on an
equal footing with the most important plasma-chemical reactions. For given
external voltage and pressure, the model determines the electric potential
within the discharge and the distribution functions for electrons, negatively
charged atomic oxygen, and positively charged molecular oxygen. Previously used
scattering and reaction cross section data are critically assessed and in some
cases modified. To validate our model, we compare the densities in the bulk of
the discharge with experimental data and find good agreement, indicating that
essential aspects of an oxygen discharge are captured.Comment: 11 pages, 10 figure
Glutamatergic medication in the treatment of obsessive compulsive disorder (OCD) and autism spectrum disorder (ASD) - study protocol for a randomised controlled trial
BACKGROUND: Compulsivity is a cross-disorder trait underlying phenotypically distinct psychiatric disorders that emerge in childhood or adolescence. Despite the effectiveness of serotonergic compounds in the treatment of obsessive-compulsive disorder, treatment-resistant symptoms remaining in 40 to 60 % of patients present a pressing clinical problem. There are currently no medications that effectively treat the core impairments of autism spectrum disorder. There is an urgent need for the development of conceptually novel pharmacological strategies. Agents targeting glutamate neurotransmission, such as memantine, represent promising candidates. This proof-of-concept clinical study will allow pilot-testing of memantine for both clinical effectiveness and tolerability/safety. Memantine is an N-methyl-D-aspartate receptor antagonist, approved for the treatment of Alzheimer's dementia in a number of countries. METHODS/DESIGN: This 12-week study has an add-on, randomised, double-blind, placebo-controlled design of treatment with memantine, including an up-titration phase (forced flexible dose design, 5-15 mg/day), in patients aged 6-17 years and 9 months with obsessive-compulsive disorder or autism spectrum disorder. It is planned to include patients with obsessive-compulsive disorder (N = 50) or autism spectrum disorder (N = 50) across four centres in three European countries. Patients will be randomly assigned to memantine or placebo in a 1:1 ratio. Primary objectives are the investigation of the effectiveness of memantine in paediatric patients for improving symptoms of compulsivity (primary outcome measure: total score on the Children's Yale-Brown Obsessive-Compulsive Scale) and to explore its tolerability and safety. Secondary objectives are to explore the effects of memantine at the level of structure, function and biochemistry of the fronto-striatal circuits, and to collect blood for genetic analyses and biomarkers. Tertiary objectives are to explore the role of new candidate genes and pathways for compulsivity by linking genes to clinical phenotypes, response to treatment, neurocognitive test performance, and key structural and functional neuroimaging measures of the fronto-striatal circuits and to explore biomarkers/proteomics for compulsivity traits. DISCUSSION: This study is part of the large, translational project TACTICS ( http://www.tactics-project.eu/ ) that is funded by the European Union and investigates the neural, genetic and molecular factors involved in the pathogenesis of compulsivity. Its results will provide clinically relevant solid information on potential new mechanisms and medication treatment in obsessive-compulsive and autism spectrum disorders. TRIAL REGISTRATION: EudraCT Number: 2014-003080-38 , date of registration: 14 July 2014
Search for the lepton-family-number nonconserving decay \mu -> e + \gamma
The MEGA experiment, which searched for the muon- and electron-number
violating decay \mu -> e + \gamma, is described. The spectrometer system, the
calibrations, the data taking procedures, the data analysis, and the
sensitivity of the experiment are discussed. The most stringent upper limit on
the branching ratio of \mu -> e + \gamma) < 1.2 x 10^{-11} was obtained
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