Approach for GDPR Compliant Detection of COVID-19 Infection Chains

While prospect of tracking mobile devices' users is widely discussed all over European countries to counteract COVID-19 propagation, we propose a Bloom filter based construction providing users' location privacy and preventing mass surveillance. We apply a solution based on Bloom filters data structure that allows a third party, a government agency, to perform some privacy-preserving set relations on a mobile telco's access logfile. By computing set relations, the government agency, given the knowledge of two identified persons, has an instrument that provides a (possible) infection chain from the initial to the final infected user no matter at which location on a worldwide scale they are. The benefit of our approach is that intermediate possible infected users can be identified and subsequently contacted by the agency. With such approach, we state that solely identities of possible infected users will be revealed and location privacy of others will be preserved. To this extent, it meets General Data Protection Regulation (GDPR)requirements in this area

Dependability issues with ubiquitous wireless access

Recent years have witnessed a proliferation of the number of wireless technologies available to access the Internet, ranging from wireless local area networks to cellular and broadcast systems, and ad hoc and mesh networks. While the emergence of these new technologies can enable truly ubiquitous Internet access, it also raises issues with the dependability of the Internet service delivered to users. Dependability in this context refers to the ability of a wireless access system to deliver specified services on which users can rely.European Community's Seventh Framework ProgramPublicad

Private Set Relations with Bloom Filters for Outsourced SLA Validation

In the area of cloud computing, judging the fulfillment of service-level agreements on a technical level is gaining more and more importance. To support this we introduce privacy preserving set relations as inclusiveness and disjointness based on Bloom filters. We propose to compose them in a slightly different way by applying a keyed hash function. Besides discussing the correctness of the set relations, we analyze how this impacts the privacy of the sets content as well as providing privacy on the sets cardinality. Indeed, our solution proposes to bring another layer of privacy on the sizes. We are in particular interested how the overlapping bits of a Bloom filter impact the privacy level of our approach. We concretely apply our solution to a use case of cloud security audit on access control and present our results with real-world parameters

Concrete Security for Entity Recognition: The Jane Doe Protocol (Full Paper)

Entity recognition does not ask whether the message is from some entity X, just whether a message is from the same entity as a previous message. This turns turns out to be very useful for low-end devices. Motivated by an attack against a protocol presented at SAC 2003, the current paper proposes a new protocol -- the ``Jane Doe Protocol\u27\u27 --, and provides a formal proof of its concrete security. The protocol neither employs asymmetric cryptography, nor a trusted third party, nor any key pre-distribution. It is suitable for light-weight cryptographic devices such as sensor network motes and RFID tags

Electrofused giant protoplasts of Saccharomyces cerevisiae as a novel system for electrophysiological studies on membrane proteins

AbstractGiant protoplasts of Saccharomyces cerevisiae of 10–35 µm in diameter were generated by multi-cell electrofusion. Thereby two different preparation strategies were evaluated with a focus on size distribution and “patchability” of electrofused protoplasts. In general, parental protoplasts were suitable for electrofusion 1–12 h after isolation. The electrophysiological properties of electrofused giant protoplasts could be analyzed by the whole-cell patch clamp technique. The area-specific membrane capacitance (0.66±0.07 µF/cm2) and conductance (23–44 µS/cm2) of giant protoplasts were consistent with the corresponding data for parental protoplasts. Measurements with fluorescein-filled patch pipettes allowed to exclude any internal compartmentalisation of giant protoplasts by plasma membranes, since uniform (diffusion-controlled) dye uptake was only observed in the whole-cell configuration, but not in the cell-attached formation. The homogeneous structure of giant protoplasts was further confirmed by the observation that no plasma membrane associated fluorescence was seen in the interior of giant cells after electrofusion of protoplasts expressing the light-activated cation channel Channelrhodopsin-2 (ChR2) linked to yellow fluorescent protein (YFP). Patch clamp analysis of the heterologously expressed ChR2-YFP showed typical blue light dependent, inwardly-directed currents for both electrofused giant and parental protoplasts. Most importantly, neither channel characteristics nor channel expression density was altered by electric field treatment. Summarising, multi-cell electrofusion increases considerably the absolute number of membrane proteins accessible in patch clamp experiments, thus presumably providing a convenient tool for the biophysical investigation of low-signal transporters and channels

Fatal bilateral pneumonitis after locoregional thoracic chemoradiation in a transplanted patient under immunosuppressive therapy

Background: After thoracic radiotherapy a pneumonitis may occur, mostly confined to the irradiated volume of the lung. In general, it resolves spontaneously without long-term effects. Case Report: A 68-year-old man was diagnosed with a stage IIIA adenocarcinoma of the lung and was treated with sequential chemoradiation. He had a heart and kidney transplant for which an immunosuppressant was taken. During the fourth week of radiotherapy, he developed a bilateral interstitial pneumonia. Despite antibiotics and steroids, the patient died twelve days after the onset of complaints due to respiratory failure. Autopsy showed in all pulmonary lobes extensive diffuse alveolar damage, probably leading to respiratory insufficiency and death. Literature and Conclusion: Bilateral pneumonitis after radiotherapy is thought to be an immunologically-mediated response, which usually resolves without long-term effects. Since in radiation pneumonitis an increase in T-cells is described, the suppression of these cells by an immunosuppressant might have exaggerated the pulmonary toxicity

pT3 colorectal cancer revisited: a multicentric study on the histological depth of invasion in more than 1000 pT3 carcinomas—proposal for a new pT3a/pT3b subclassification

BACKGROUND: Pathological TNM staging (pTNM) is the strongest prognosticator in colorectal carcinoma (CRC) and the foundation of its post-operative clinical management. Tumours that invade pericolic/perirectal adipose tissue generally fall into the pT3 category without further subdivision. METHODS: The histological depth of invasion into the pericolic/perirectal fat was digitally and conventionally measured in a training cohort of 950 CRCs (Munich). We biostatistically calculated the optimal cut-off to stratify pT3 CRCs into novel pT3a (≤3 mm)/pT3b (>3 mm) subgroups, which were then validated in two independent cohorts (447 CRCs, Bayreuth/542 CRCs, Mainz). RESULTS: Compared to pT3a tumours, pT3b CRCs showed significantly worse disease-specific survival, including in pN0 vs pN+ and colonic vs. rectal cancers (DSS: P < 0.001, respectively, pooled analysis of all cohorts). Furthermore, the pT3a/pT3b subclassification remained an independent predictor of survival in multivariate analyses (e.g. DSS: P < 0.001, hazard ratio: 4.41 for pT3b, pooled analysis of all cohorts). While pT2/pT3a CRCs showed similar survival characteristics, pT3b cancers remained a distinct subgroup with dismal survival. DISCUSSION: The delineation of pT3a/pT3b subcategories of CRC based on the histological depth of adipose tissue invasion adds valuable prognostic information to the current pT3 classification and implementation into current staging practices of CRC should be considered