Comparison of No-Reference Image Quality Models via MAP Estimation in Diffusion Latents

Contemporary no-reference image quality assessment (NR-IQA) models can effectively quantify the perceived image quality, with high correlations between model predictions and human perceptual scores on fixed test sets. However, little progress has been made in comparing NR-IQA models from a perceptual optimization perspective. Here, for the first time, we demonstrate that NR-IQA models can be plugged into the maximum a posteriori (MAP) estimation framework for image enhancement. This is achieved by taking the gradients in differentiable and bijective diffusion latents rather than in the raw pixel domain. Different NR-IQA models are likely to induce different enhanced images, which are ultimately subject to psychophysical testing. This leads to a new computational method for comparing NR-IQA models within the analysis-by-synthesis framework. Compared to conventional correlation-based metrics, our method provides complementary insights into the relative strengths and weaknesses of the competing NR-IQA models in the context of perceptual optimization

Case report: Sequential therapy with dupilumab and baricitinib for severe alopecia areata with atopic dermatitis in children

An 8-year-old female child presented with patchy hair loss for 1 year, accompanied by eyebrow loss for 6 months. Microscopic examination of the hair confirmed the features of active stage alopecia areata, with a Severity of Alopecia Tool (SALT) score of 70%. The diagnosis was severe alopecia areata. The patient had a history of atopic dermatitis since infancy, with recurrent episodes of scattered papules and pruritus for 8 years. Initial treatment involved subcutaneous injections of dupilumab 300mg every 2 weeks for 6 months, resulting in a reduction of SALT score to 20% and improvement of atopic dermatitis symptoms. Discontinuation of Dupilumab and initiation of daily oral Baricitinib at a dose of 2mg for a duration of 5 months. According to the SALT score evaluation, the severity of hair loss was less than 10% and there was significant regrowth of hair. No significant adverse reactions were observed during the treatment period

Liposuction-assisted circumferential trimming in treatment of axillary osmidrosis (AO)

<p><b>Background:</b> The study is to investigate the effectiveness and safety of the minimally invasive treatment for axillary osmidrosis by liposuction assisted circumferential trimming.</p> <p><b>Methods:</b> It was a retrospective study. From July 2014 to July 2017, 79 patients underwent superficial liposuction and circumferential trimming for bilateral axillary osmidrosis. The preoperative and postoperative degree of axillary malodor was measured by doctors and the patients themselves. In the doctor’s evaluation, the odor levels were scored by the sniffing method before and 1 year after treatment. In the patient’s self-assessment, each patient selected a scale value to convey his/her satisfaction during the visits after 1 year. The complications were recorded.</p> <p><b>Results:</b> The follow-up period ranged from 12 to 24 months after surgery, and the mean follow-up period was 16 months. 75 (94.9%) had good results, four (5.1%) had moderate malodor or recurrence after one year. When considering patient’s own satisfaction, 93.7% (74/79) of patients were satisfied with the outcomes after one year. The partial epidermis necrosis was observed in four patients, it healed spontaneously without scarring. Three patients had a small amount of hematoma which was easily evacuated through the central primary incision. There was no other serious side effect.</p> <p><b>Conclusions:</b> The liposuction assisted circumferential trimming technique is proved reliable and safe in treatment for axillary osmidrosis.</p

Continual Learning for Blind Image Quality Assessment

The explosive growth of image data facilitates the fast development of image processing and computer vision methods for emerging visual applications, meanwhile introducing novel distortions to the processed images. This poses a grand challenge to existing blind image quality assessment (BIQA) models, failing to continually adapt to such subpopulation shift. Recent work suggests training BIQA methods on the combination of all available human-rated IQA datasets. However, this type of approach is not scalable to a large number of datasets, and is cumbersome to incorporate a newly created dataset as well. In this paper, we formulate continual learning for BIQA, where a model learns continually from a stream of IQA datasets, building on what was learned from previously seen data. We first identify five desiderata in the new setting with a measure to quantify the plasticity-stability trade-off. We then propose a simple yet effective method for learning BIQA models continually. Specifically, based on a shared backbone network, we add a prediction head for a new dataset, and enforce a regularizer to allow all prediction heads to evolve with new data while being resistant to catastrophic forgetting of old data. We compute the quality score by an adaptive weighted summation of estimates from all prediction heads. Extensive experiments demonstrate the promise of the proposed continual learning method in comparison to standard training techniques for BIQA. We made the code publicly available at https://github.com/zwx8981/BIQA_CL.Comment: Accepted to IEEE TPAM

Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management

AbstractGadolinium-based MR cisternography has been mainly applied in clinical evaluation of cerebrospinal fluid leaking, that is conducted by intrathecal administration of contrast media. Recently, we have reported one novel technique of intrathecal targeted drug delivery with prepontine cisternal routine to treat orofacial cancer pain. The aim of this study was to examine the distribution pattern of this intrathecal drug delivery strategy. Here, we introduce one case who suffered severe orofacial pain caused by sublingual gland tumor, and successfully attenuated by prepontine cisternal administration of analgesic agents. To assess the distribution of intrathecal drugs, postoperative MR images of brain, cervical, thoracic, and lumbar segments in axial, coronal, and sagittal planes were obtained after application of gadolinium. The perfusion rate of contrast medium was set at 0.01 mmol per hour for 24 hours prior to MR scanning. In the T1-weighted images, we can identify contrast spread not only locating around the site of the intrathecal catheter tip, but also concentrated to the lateral sides. None obvious side effect was found after intrathecal injection of contrast media. Thus, our finding demonstrated the local distribution phenomenon of intrathecal drugs through prepontine cisternal access, and the bilateral perfusion pattern may provide insights underlying the analgesic mechanism of trigeminal pain provided by this novel intrathecal therapy. Gadolinium-based MR cisternography may serve as a potential tool to confirm the therapeutic effect of intrathecal targeted drug delivery via prepontine cisternal routine in orofacial pain management

Characterization of Highbush Blueberry (<i>Vaccinium corymbosum</i> L.) Anthocyanin Biosynthesis Related MYBs and Functional Analysis of <i>VcMYB</i> Gene

As one of the most important transcription factors regulating plant anthocyanin biosynthesis, MYB has attracted great attentions. In this study, we identified fifteen candidate anthocyanin biosynthesis related MYB (ABRM) proteins, including twelve R2R3-MYBs and three 1R-MYBs, from highbush blueberry. The subcellular localization prediction results showed that, with the exception of VcRVE8 (localized in chloroplast and nucleus), all of the blueberry ABRMs were nucleus-localized. The gene structure analysis revealed that the exon numbers of the blueberry ABRM genes varied greatly, ranging between one and eight. There are many light-responsive, phytohormone-responsive, abiotic stress-responsive and plant growth and development related cis-acting elements in the promoters of the blueberry ABRM genes. It is noteworthy that almost all of their promoters contain light-, ABA- and MeJA-responsive elements, which is consistent with the well-established results that anthocyanin accumulation and the expression of MYBs are influenced significantly by many factors, such as light, ABA and JA. The gene expression analysis revealed that VcMYB, VcMYB6, VcMYB23, VcMYBL2 and VcPH4 are expressed abundantly in blueberry fruits, and VcMYB is expressed the highest in the red, purple and blue fruits among all blueberry ABRMs. VcMYB shared high similarity with functionally proven ABRMs from many other plant species. The gene cloning results showed that VcMYB had three variable transcripts, but only the transient overexpression of VcMYB-1 promoted anthocyanin accumulation in the green fruits. Our study can provide a basis for future research on the anthocyanin biosynthesis related MYBs in blueberry

Charge defects-induced electrical properties in bismuth ferrite bilayered thin films

10.1016/j.materresbull.2013.03.042Materials Research Bulletin4882973-2977MRBU