Contribution to Determination of Hepatitis C Virus Genotypes in Black Sea Region: Data from Single High Volume Center in Zonguldak, Turkey

WOS: 000341223900019PubMed: 25052121We've read with great interest the article entitled "Determination of hepatitis C virus genotypes among hepatitis C patients in Eastern Black Sea Region, Turkey" by Buruk et al. published in Mikrobiyol Bul 2013; 47(4): 650-7. In that study, the authors described the determination and distribution of hepatitis C virus (HCV) genotypes in Eastern Black Sea Region comprehensively. According to the current information, the determination of HCV genotypes is the most important factor for the management of therapy and virus-related complications, such as chirrhosis and hepatocellular carcinoma. The distribution of HCV genotypes varies geographically throughout the world. Therefore every country and even each region within the country should know the distribution of HCV genotypes to determine the appropriate treatment strategy. Herein we would like to contribute the data about distribution of HCV genotypes in whole Black Sea Region by presenting our current results obtained from Zonguldak province, where maximum number of chronic hepatit C patients have already been identified in Eastern Black Sea Region. A total of 53 chronic hepatitis C patients (26 female, 27 male; mean age: 57.1 +/- 14.3, age range: 21-82 years) who were admitted to Zonguldak Ataturk State Hospital between January 2012-December 2013 were evaluated. Genotype analysis was performed by RealTime HCV Genotype II (Abbott Molecular, ABD) system. Genotype-1 was found to be the most frequently detected type with a rate of 96.2% (51/53). The prevalences of genotype-2 (1/53) and genotype-4 (1/53) were same, with a rate of 1.9%, in our study. Subtyping of genotype-1 strains yielded 52.9% (27/51) genotype-1b, 3.9% genotype-1a (2/51) and 47% untypeable genotype-1 (24/51). The present study was the second study from the Western Black Sea Region in our country, regarding HCV genotypes. In conclusion, considering entire Black Sea Region, genotype-1 is the most common genotype (96.2%), and 1b (52.9%) is the most common subtype, in parallel to the data reported from the other regions of Turkey

Newly Diagnosed Crohn's Disease in Patient with Familial Mediterranean Fever

WOS: 000372285800011PubMed: 26923897Chronic abdominal pain sometimes constitute a abdominal pain in both. At this point, clinicians ajor challenge, specially when a patient has two diseasesh dominant featureso daunting task bothin diagnosing and treating anindividual's chronic abdominal pa Similarly, familial Mediterranean fever disease and Crohn's disease have the same clinical features in terms of chronic abdominal pain, inflammatory properties.. and inflammatory properties of these diseases. The association of familial Mediterranean fever disease and Crohn's disease is very rare and may lead to a remarkable challenge in both diagnosis and treatment. Here, we report a young man with FMF disease presented with extraordinary and intolerable abdominal pain relieved only by excessive narcotic analgesics. The presented case was diagnosed with CD and successfully treated with anti-TNF (tumor necrosis factor) due to steroid refractor

Could erythropoietin reduce the ovarian damage of cisplatin in female rats?

Ozkan, Zehra Sema/0000-0001-9185-3663WOS: 000428813900013PubMed: 29084473The aim of this study is to investigate whether erythropoietin (EPO) can reduce the ovarian damage of cisplatin or not. Thirty, female, Wistar-Albino rats were used in the study. Control group (N=10): Intraperitoneal saline infusion, Cisplatin group (N=10): Intraperitoneal 7mg/kg cisplatin, Cisplatin+EPO group (N=10): Intraperitoneal 7mg/kg cisplatin and subcutaneous 200IU/kg/day EPO. Serum AMH concentrations were measured by enzyme-linked immunosorbent assay kit of AMH. Follicular counts were evaluated according to mean diameter of the follicles. Ovarian damage; including follicular cell degeneration, vascular congestion, hemorrhage, and inflammation was scored histologically using a graduated scale. Posttreatment AMH levels of cisplatin group were significantly lower than control and cisplatin+EPO groups. In cisplatin group, there was a significant decrement in posttreatment AMH level compared to pretreatment AMH level. The total damage score of cisplatin group was significantly higher than scores of control and cisplatin+EPO groups. The mean primordial follicle counts of control and cisplatin+EPO groups were significantly higher than that of cisplatin group (p=.007 and p=.003). The results of this study revealed that EPO administration to cisplatin chemotherapy could ameliorate the ovarian damage. Erythropoietin administration to chemotherapeutic agents might suggest to protect ovarian failure and infertility.Kirikkale University Scientific Research Commission [2015/06]This research was funded by Kirikkale University Scientific Research Commission (project number: 2015/06). The authors are grateful to Kirikkale University, for their valuable support

Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers

AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies