Prediction of sanding in subsurface hydrocarbon reservoirs.

Sand production in oil and gas wells can occur if the fluid velocity exceeds a certain value. Due to drilling operations, the mechanical stresses can exceed the load bearing capacity of the rock. As the local stresses exceed certain level, a certain amount of rock is fractured into sand. Then, the sand is carried by the fluid through the wellbore depending on the flow rate. The amount of the solids can be less than a few grams per cubic meter of reservoir fluid or an essential amount. In the later case erosion of the rock and removing sufficient quantities of rock can occur. This can produce subsurface cavities which collapse and destroy the well. When sanding is unavoidable it is necessary to estimate the characteristics of the process. Our aim was to generate a simple one-dimensional local model, which predicts the volume of sanding, the radius and the porosity of the yielded zone. Such model will help the company in the development of complex 3D models

STUDY OF STRENGTH TRAINING IN 400 M SPRINT FOR GIRLS UNDER 18 YEARS

Studying the different sides of 400 m sports preparation is a key factor for the proper development of sports results. Strength training is one of the most important parts of sprint running. The object of the study is sports training of athletes in the 400 m sprint, and in particular strength training. The subject is the content and volume of the annual preparation for girls under 18, specializing in 400 m sprint. We used the following methods: sports-pedagogical and technical-tactical analysis of athletes; interview; Case-study analysis; Mathematical and statistical methods. We analyzed: 16 macrocycles. Girls under 18 years have a large set of auxiliary exercises for strength training-total of 52. Volumetric characteristics must be precisely used according to age and individual qualities. We established minimum, maximum, and average volume values of the various means in macro-, meso- and microcycles. In conclusion, we can note the need for more scientific and methodological developments to help the process of applying specific volumes for the different strength exercises, during the different periods of annual preparation. With this study, we present relevant information for the volume and diversity of used athletic means used in practice and can help other coaches

Dynamics of nearly spherical vesicles in an external flow

We analytically derive an equation describing vesicle evolution in a fluid where some stationary flow is excited regarding that the vesicle shape is close to a sphere. A character of the evolution is governed by two dimensionless parameters, $S$ and $\Lambda$, depending on the vesicle excess area, viscosity contrast, membrane viscosity, strength of the flow, bending module, and ratio of the elongation and rotation components of the flow. We establish the ``phase diagram'' of the system on the $S-\Lambda$ plane: we find curves corresponding to the tank-treading to tumbling transition (described by the saddle-node bifurcation) and to the tank-treading to trembling transition (described by the Hopf bifurcation).Comment: 4 pages, 1 figur

Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia

Objective: Treatment of acute lymphoblastic leukemia (ALL) in adults focuses on the initial assessment of the prognostic relevant cytogenetic features as well as a response-guided therapy based on molecular data. We examined the importance of molecular-cytogenetic abnormalities for complete remission (CR) rates and the overall survival (OS) in adult ALLs.Materials and Methods: Conventional cytogenetics and fluorescence in situ hybridization were performed on bone marrow cells from 33 newly-diagnosed ALL adults. Two karyotype categories [standard- risk group- normal karyotype, hyperdiplody and other structural aberrations, and high-risk group-t(11q23)/MLL, t(9;22)/bcr-abl, t(1;19), t(8;14), C-MYC and complex karyotype] and the biologically and clinically relevant ALL ploidy subgroups were prospectively defined.Results: Chromosomal abnormalities were found in 52% of the cases with a high rate of poor-risk translocations - t(9;22), t(8q24), t(11q23), t(1;19). The total CR rate was 67% and the median time for achievement 2.33 months. Male sex, an age below 35 years and the absence of high risk translocations might have contributed to the high CR rates. Female patients, hyperdiplody, low white blood cells (WBC), and random cytogenetic aberrations had the longest OS. OS, 3- and 5-years survival periods were significantly shorter for poor-risk than standard risk group (p=.015, p=.001 and p=.005, respectively).Conclusion: This study emphasizes the lack of influence of cytogenetic aberrations on the CR and the time to achieve CR. However, our observations show that these aberrations are an independent prognostic factor in adult ALL - they allow predicting therapy resistance and the OS time after intensetreatment

Parallelizing multiple precision Taylor series method for integrating the Lorenz system

A hybrid MPI+OpenMP strategy for parallelizing multiple precision Taylor series method is proposed, realized and tested. To parallelize the algorithm we combine MPI and OpenMP parallel technologies together with GMP library (GNU miltiple precision libary) and the tiny MPIGMP library. The details of the parallelization are explained on the paradigmatic model of the Lorenz system. We succeed to obtain a correct reference solution in the rather long time interval - [0,7000]. The solution is verified by comparing the results for 2700-th order Taylor series method and precision of ~ 3374 decimal digits, and those with 2800-th order and precision of ~ 3510 decimal digits. With 192 CPU cores in Nestum cluster, Sofia, Bulgaria, the 2800-th order computation was ~ 145 hours with speedup ~ 105.Comment: arXiv admin note: text overlap with arXiv:1908.0930