A Worldwide Production Grid Service Built on EGEE and OSG Infrastructures â Lessons Learnt and Long-term Requirements

Using the Grid Infrastructures provided by EGEE, OSG and others, a worldwide production service has been built that provides the computing and storage needs for the 4 main physics collaborations at CERN's Large Hadron Collider (LHC). The large number of users, their geographical distribution and the very high service availability requirements make this experience of Grid usage worth studying for the sake of a solid and scalable future operation. This service must cater for the needs of thousands of physicists in hundreds of institutes in tens of countries. A 24x7 service with availability of up to 99% is required with major service responsibilities at each of some ten "Tier1" and of the order of one hundred "Tier2" sites. Such a service - which has been operating for some 2 years and will be required for at least an additional decade - has required significant manpower and resource investments from all concerned and is considered a major achievement in the field of Grid computing. We describe the main lessons learned in offering a production service across heterogeneous Grids as well as the requirements for long-term operation and sustainability

TooManyEyes: Super-recogniser directed identification of target individuals on CCTV

For the current research, a ‘Spot the Face in a Crowd Test’ (SFCT) comprising six video clips depicting target-actors and multiple bystanders was loaded on TooManyEyes, a bespoke multi-media platform adapted here for the human-directed identification of individuals in CCTV footage. To test the utility of TooManyEyes, police ‘super-recognisers’ (SRs) who may possess exceptional face recognition ability, and police controls attempted to identify the target-actors from the SFCT. As expected, SRs correctly identified more target-actors; with higher confidence than controls. As such, the TooManyEyes system provides a useful platform for uploading tests for selecting police or security staff for CCTV review deploymen

The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis

Juvenile-onset lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients (JSLE). As the exact role of human renal glomerular endothelial cells (GEnCs) in LN has not been fully elucidated, the aim of this study was to investigate their involvement in LN. Conditionally immortalised human GEnCs (ciGEnCs) were treated with pro-inflammatory cytokines known to be involved in LN pathogenesis and also with LPS. Secretion and surface expression of pro-inflammatory proteins was quantified via ELISA and flow cytometry. NF-κΒ and STAT-1 activation was investigated via immunofluorescence. Serum samples from JSLE patients and from healthy controls were used to treat ciGEnCs to determine via qRT-PCR potential changes in the mRNA levels of pro-inflammatory genes. Our results identified TNF-α, IL-1β, IL-13, IFN-γ and LPS as robust in vitro stimuli of ciGEnCs. Each of them led to significantly increased production of different pro-inflammatory proteins, including; IL-6, IL-10, MCP-1, sVCAM-1, MIP-1α, IP-10, GM-CSF, M-CSF, TNF-α, IFN-γ, VCAM-1, ICAM-1, PD-L1 and ICOS-L. TNF-α and IL-1β were shown to activate NF-κB, whilst IFN-γ activated STAT-1. JSLE patient serum promoted IL-6 and IL-1β mRNA expression. In conclusion, our in vitro model provides evidence that human GEnCs play a pivotal role in LN-associated inflammatory process

NELIOTA: The wide-field, high-cadence lunar monitoring system at the prime focus of the Kryoneri telescope

We present the technical specifications and first results of the ESA-funded, lunar monitoring project "NELIOTA" (NEO Lunar Impacts and Optical TrAnsients) at the National Observatory of Athens, which aims to determine the size-frequency distribution of small Near-Earth Objects (NEOs) via detection of impact flashes on the surface of the Moon. For the purposes of this project a twin camera instrument was specially designed and installed at the 1.2 m Kryoneri telescope utilizing the fast-frame capabilities of scientific Complementary Metal-Oxide Semiconductor detectors (sCMOS). The system provides a wide field-of-view (17.0' $\times$ 14.4') and simultaneous observations in two photometric bands (R and I), reaching limiting magnitudes of 18.7 mag in 10 sec in both bands at a 2.5 signal-to-noise level. This makes it a unique instrument that can be used for the detection of NEO impacts on the Moon, as well as for any astronomy projects that demand high-cadence multicolor observations. The wide field-of-view ensures that a large portion of the Moon is observed, while the simultaneous, high-cadence, monitoring in two photometric bands makes possible, for the first time, the determination of the temperatures of the impacts on the Moon's surface and the validation of the impact flashes from a single site. Considering the varying background level on the Moon's surface we demonstrate that the NELIOTA system can detect NEO impact flashes at a 2.5 signal-to-noise level of ~12.4 mag in the I-band and R-band for observations made at low lunar phases ~0.1. We report 31 NEO impact flashes detected during the first year of the NELIOTA campaign. The faintest flash was at 11.24 mag in the R-band (about two magnitudes fainter than ever observed before) at lunar phase 0.32. Our observations suggest a detection rate of $1.96 \times 10^{-7}$ events $km^{-2} h^{-1}$.Comment: Accepted for publication in A&

Nanomaterials exposure as an occupational risk in metal additive manufacturing

Metal Additive Manufacturing (AM) is a process of joining metallic materials based on 3D model data, aiming the manufacture of three dimensional parts by the successive addition of material, usually layer upon layer. This technology is nowadays seen as an emerging one, showing exceptional perspectives of growth, being able to produce parts in various materials such as precious metals (for example gold, silver and platinum) and several metal alloys, such as aluminium, titanium, nickel, cobalt and magnesium based alloys, among others. However, as the range of feedstock materials, technologies and applications increases, so do the concerns about its impact on health and safety of those who are exposed to the particles emitted during these processes, particularly when AM uses metal powder. Regarding emissions, studies thus far show that nanomaterials are emitted during AM processes, a fact that rises the concern about its impacts and enhances the complexity of risk management on these processes. When risk management aims nanoscale, it becomes a true challenge as it deals with several different nanomaterials and the lack of systematic and standardized risk assessment methodologies. At this scale, risk management raises many doubts regarding the selection of quantitative or qualitative approaches, the identification, characterization and quantification of nanomaterials, the definition of occupational exposure limits and the outlining of control measures. Having this conscience, a review was developed to summarize some of the recent developments in the field of risk management of occupational exposure to nanomaterials during metal additive manufacturing. Additionally, this review emphasizes the need for more investigation about risks regarding nanomaterials in workplaces, which is essential to ensure workers' safety conditions and preserve their health, as well as to make conscious decisions on risk assessment, public health, medical monitoring and control measures,- (undefined

On the absence of bound-state stabilization through short ultra-intense fields

We address the question of whether atomic bound states begin to stabilize in the short ultra-intense field limit. We provide a general theory of ionization probability and investigate its gauge invariance. For a wide range of potentials we find an upper and lower bound by non-perturbative methods, which clearly exclude the possibility that the ultra intense field might have a stabilizing effect on the atom. For short pulses we find almost complete ionization as the field strength increases.Comment: 34 pages Late

On the Influence of Pulse Shapes on Ionization Probability

We investigate analytical expressions for the upper and lower bounds for the ionization probability through ultra-intense shortly pulsed laser radiation. We take several different pulse shapes into account, including in particular those with a smooth adiabatic turn-on and turn-off. For all situations for which our bounds are applicable we do not find any evidence for bound-state stabilization.Comment: 21 pages LateX, 10 figure