Low power general purpose loop acceleration for NDP applications

Modern processor architectures face a throughput scaling problem as the performance bottleneck shifts from the core pipeline to the data transfer operations between the dynamic random access memory (DRAM) and the processor chip. To address such issue researchers have proposed the near-data processing (NDP) paradigm in which the instruction execution is moved to the DRAM die thus, lowering the data movement between the processor and the DRAM. Previous NDP works focus on specific application types and thus the general purpose application execution paradigm is neglected. In this work we propose an NDP methodology for low power general purpose loop acceleration. For this reason we design and implement a hardware loop accelerator from the ground up to improve the throughput and lower the power consumption of general purpose loops. We adopt a novel loop scheduling approach which enables the loop accelerator to take advantage of the dataflow parallelism of the executing loop and we implement our design on the logic layer of a hybrid memory cube (HMC) DRAM. Post-layout simulations demonstrate an average speedup factor of 20.5x when executing kernels from various scientific fields while the energy consumption is reduced by a factor of 9.3x over the host CPU execution

The influence of repeated cold water immersion on adaptations to strength and power training

Introduction Cold Water Immersion (CWI) is a popular recovery strategy utilised by athletes in order to attenuate the negative influence of strenuous exercise on subsequent performance. One of the proposed physiological mechanisms underpinning the use of CWI is the potential to limit the inflammatory response after acute exercise. Given that the inflammatory cascade ultimately leads to muscle regeneration and repair, it is pertinent to investigate the longer term impact of regular cryotherapy exposure on adaptations to strength and power training. Methods Thirteen resistance trained males (mean age 25.8 ± 5.5 years; height 1.8 ± 0.1 m; mass 83.6 ± 15.7 kg; 4RM back squat 146.2 ± 38.5 kg) completed an 8 week (1 x 4 week strength and 1 x 4 week power block) lower body resistance training program. Participants were match-paired into either the CWI (10 min at 10° ± 0.5°) or placebo group based on a ratio of lean mass to 4RM back squat. Participants completed 2 training sessions per week and completed their allocated recovery intervention after each training session. Measures of muscle fibre pennation angle, maximal voluntary isometric contraction (MVIC) at 90°, peak torque of the knee extensors (60deg∙s), and isometric squat parameters (peak force and rate of force development (RFD))were measured at baseline, midpoint and post training intervention. Results were analysed using magnitude based inferences. Results At the post testing session, CWI demonstrated a likely moderate harmful effect on muscle fibre pennation angle compared to the placebo group (CWI: 11.4; ±4.8%; placebo: 21.5; ±8.4%). However, CWI demonstrated a likely large beneficial effect on peak torque (60deg∙s) compared to the placebo group (CWI: 7.5; ±6.5%; placebo: -2.4; ±4.0%) at midpoint. There were trivial differences between groups for isometric peak force and peak torque (60deg∙s) from baseline to post. All other effects were unclear. Discussion The greater increase in muscle fibre pennation angle in the placebo group compared to the CWI group would indicate a greater increase lean muscle mass. However, CWI still demonstrated a positive impact on peak torque at 60 deg∙s compared to the placebo group. Blood sample analyses are ongoing and may offer further insight into the underpinning mechanisms. Further investigation is warranted to better understand the potential negative impact of repeated cryotherapy exposure on functional adaptations to strength and power training stimuli

Whole body cryotherapy, cold water immersion, or a placebo following resistance exercise: a case of mind over matter?

PURPOSE: The use of cryotherapy as a recovery intervention is prevalent amongst athletes. Performance of high volume, heavy load resistance exercise is known to result in disturbances of muscle function, perceptual responses and blood borne parameters. Therefore, this study investigated the influence of cold water immersion (CWI), whole body cryotherapy (WBC) or a placebo (PL) intervention on markers of recovery following an acute resistance training session. METHODS: 24 resistance trained males were matched into a CWI (10 min at 10 °C), WBC (3- and 4 min at - 85 °C) or PL group before completing a lower body resistance training session. Perceptions of soreness and training stress, markers of muscle function, inflammation and efflux of intracellular proteins were assessed before, and up to 72 h post exercise. RESULTS: The training session resulted in increased soreness, disturbances of muscle function, and increased inflammation and efflux of intracellular proteins. Although WBC attenuated soreness at 24 h, and positively influenced peak force at 48 h compared to CWI and PL, many of the remaining outcomes were trivial, unclear or favoured the PL condition. With the exception of CRP at 24 h, neither cryotherapy intervention attenuated the inflammatory response compared to PL. CONCLUSION: There was some evidence to suggest that WBC is more effective than CWI at attenuating select perceptual and functional responses following resistance training. However, neither cryotherapy intervention was more effective than the placebo treatment at accelerating recovery. The implications of these findings should be carefully considered by individuals employing cryotherapy as a recovery strategy following heavy load resistance training

Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid

Infant formula based on pea (Pisum sativum)-protein isolate has been suggested as an alternative to soyabean formula in countries where soyabean is not a native crop, or when soyabean protein cannot be used due to allergic reactions or intolerances. In the present study, Fe absorption from experimental infant formulas based on pea-protein isolate was measured in healthy non-anaemic young women. The influence of phytic acid and ascorbic acid on Fe absorption was evaluated, using a stable-isotope technique based on incorporation of Fe stable-isotope labels into erythrocytes 14 d after administration. Geometric mean Fe absorption increased from 20·7 (+1SD 41·6, -1sd 10·3) % to 33·1 (+1sd 58·6, -1sd 18·7) %; (P<0·0001; n 10) after enzymic degradation of virtually all phytic acid. Doubling the molar ratio Fe : ascorbic acid from 1 : 2·1 to 1 : 4·2 in the infant formula with native phytic acid content also increased Fe absorption significantly (P<0·0001; n 10); geometric mean Fe absorption increased from 14·8 (+1sd 32·1, -1sd 6·8) % to 22·1 (+1sd 47·2, -1sd 10·4) %. These results confirm the inhibitory and enhancing effects of phytic acid and ascorbic acid respectively on Fe absorption, but also indicate relatively high fractional Fe absorption from the pea-protein-based formulas. After adjusting for differences in Fe status, our data indicate that Fe absorption from dephytinised pea protein might be less inhibitory than dephytinised soyabean protein as measured in a previous study (

Can children with autism read emotions from the eyes? The eyes test revisited

This study aimed to test two new, simplified tasks related to the eye-test, targeting children with Autism Spectrum Disorder (ASD) and typically developing controls (TD). Test-1 assessed the recognition of emotion/mental states with displays using one word and two eye-pictures, whereas Test-2 presented displays using two words and one eye-picture. Black and white photographs of children were used as materials. A cross-cultural study (Caucasian/East-Asian) with adults was initially carried out to verify generalizability across different ethnic groups. Cross-sectional trajectory analyses were used to compare emotion recognition from the eyes in the two tests. Trajectories were constructed linking performance on both tests either to chronological age or to different measures of mental age (receptive vocabulary based on the BPVS, CARS or ASQ for the ASD group). Performance improved with chronological age in both the ASD and TD groups of children. However, performance in Test-1 was significantly superior in children with ASD, who showed delayed onset and slower rate of improvement than TD children in Test-2. In both the ASD and TD groups the lowest error rate was recorded for the item ‘anger’, suggesting that threat-detection cue mechanisms may be intact in Autism. In general, all children showed good performance on our novel tests, thus making them good candidates for assessing younger children and those with lower general abilities

Simple mindreading abilities predict complex theory of mind: developmental delay in autism spectrum disorders

Theory of Mind (ToM) is impaired in individuals with Autism Spectrum Disorders (ASD). The aims of this study were to: i) examine the developmental trajectories of ToM abilities in two different mentalizing tasks in children with ASD compared to TD children; and ii) to assess if a ToM simple test known as Eyes-test could predict performance on the more advanced ToM task, i.e. Comic Strip test. Based on a sample of 37 children with ASD and 55 TD children, our results revealed slower development at varying rates in all ToM measures in children with ASD, with delayed onset compared to TD children. These results could stimulate new treatments for social abilities, which would lessen the social deficit in ASD

Health‐related quality of life in survivors of advanced melanoma treated with anti‐PD1‐based immune checkpoint inhibitors

Background: Immune checkpoint inhibitors (ICIs) have significantly improved survival in advanced melanoma but are associated with immune-related adverse events (irAEs). This single center, cross-sectional survey aimed to describe the long-term symptom burden and impact on health-related quality of life (HRQL) of advanced melanoma patients with sustained disease control following treatment with ICIs. Methods: Advanced melanoma patients (stage IIB, III or IV, AJCCv8), treated with anti-PD1-based ICIs, who were off-treatment and had at least 6 months follow-up from their last infusion with an ongoing response in the metastatic setting or no evidence of disease recurrence in the adjuvant setting. A paper-based questionnaire, consisting of the EORTC QLQ-C30, EORTC QLQ-FA12, and the PRO-CTCAE was administered. Results: Of 90 participants, 61 (68%) completed the questionnaire; 40 received single-agent anti-PD1, and 21 anti-PD1/anti-CTLA4. Thirty-three (54%) were treated in the adjuvant setting. At the time of enrolment, 31 (51%) participants had active treatment for a previous irAE. Overall, 18/61 (30%) participants reported long-term symptoms and trouble in physical and emotional functioning. Physical fatigue was common and interfered with daily activities (n = 12, 20%). In the PRO-CTCAE questionnaire, muscle ache (n = 12, 20%) and joint ache (n = 9, 15%) were commonly reported. Despite this, participants reported overall good health (6.00, range 2.00-7.00) and reasonable level of HRQL (6.00, range 3.00-7.00). Discussion: Melanoma survivors experience long-term symptoms in physical and psychosocial HRQL domains after ICI treatment. These results underline the importance to address existing gaps in survivorship care, implement these findings in clinical practice and increase awareness for long-term symptoms in these patients